Radiolabeled Small Molecule Protein Kinase Inhibitors for Imaging with PET or SPECT
Imaging protein kinase expression with radiolabeled small molecule inhibitors has been actively pursued to monitor the clinical potential of targeted therapeutics and treatments as well as to determine kinase receptor density changes related to disease progression. The goal of the present review is...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-11-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/15/11/8260/ |
| _version_ | 1818758753722302464 |
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| author | Justin W. Hicks Henry F. VanBrocklin Alan A. Wilson Sylvain Houle Neil Vasdev |
| author_facet | Justin W. Hicks Henry F. VanBrocklin Alan A. Wilson Sylvain Houle Neil Vasdev |
| author_sort | Justin W. Hicks |
| collection | DOAJ |
| description | Imaging protein kinase expression with radiolabeled small molecule inhibitors has been actively pursued to monitor the clinical potential of targeted therapeutics and treatments as well as to determine kinase receptor density changes related to disease progression. The goal of the present review is to provide an overview of the breadth of radiolabeled small molecules that have been synthesized to target intracellular protein kinases, not only for imaging in oncology, but also for other areas of interest, particularly the central nervous system. Considerable radiotracer development has focused on imaging receptor tyrosine kinases of growth factors, protein kinases A, B and C, and glycogen synthase kinase–3β. Design considerations, structural attributes and relevant biological results are summarized. |
| first_indexed | 2024-12-18T06:31:51Z |
| format | Article |
| id | doaj.art-4ba6bb47642341d498106a04df367dfe |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-18T06:31:51Z |
| publishDate | 2010-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4ba6bb47642341d498106a04df367dfe2022-12-21T21:17:53ZengMDPI AGMolecules1420-30492010-11-0115118260827810.3390/molecules15118260Radiolabeled Small Molecule Protein Kinase Inhibitors for Imaging with PET or SPECTJustin W. HicksHenry F. VanBrocklinAlan A. WilsonSylvain HouleNeil VasdevImaging protein kinase expression with radiolabeled small molecule inhibitors has been actively pursued to monitor the clinical potential of targeted therapeutics and treatments as well as to determine kinase receptor density changes related to disease progression. The goal of the present review is to provide an overview of the breadth of radiolabeled small molecules that have been synthesized to target intracellular protein kinases, not only for imaging in oncology, but also for other areas of interest, particularly the central nervous system. Considerable radiotracer development has focused on imaging receptor tyrosine kinases of growth factors, protein kinases A, B and C, and glycogen synthase kinase–3β. Design considerations, structural attributes and relevant biological results are summarized.http://www.mdpi.com/1420-3049/15/11/8260/molecular imagingprotein kinasesmall molecules inhibitorspositron emission tomographysingle photon emission computer tomography |
| spellingShingle | Justin W. Hicks Henry F. VanBrocklin Alan A. Wilson Sylvain Houle Neil Vasdev Radiolabeled Small Molecule Protein Kinase Inhibitors for Imaging with PET or SPECT Molecules molecular imaging protein kinase small molecules inhibitors positron emission tomography single photon emission computer tomography |
| title | Radiolabeled Small Molecule Protein Kinase Inhibitors for Imaging with PET or SPECT |
| title_full | Radiolabeled Small Molecule Protein Kinase Inhibitors for Imaging with PET or SPECT |
| title_fullStr | Radiolabeled Small Molecule Protein Kinase Inhibitors for Imaging with PET or SPECT |
| title_full_unstemmed | Radiolabeled Small Molecule Protein Kinase Inhibitors for Imaging with PET or SPECT |
| title_short | Radiolabeled Small Molecule Protein Kinase Inhibitors for Imaging with PET or SPECT |
| title_sort | radiolabeled small molecule protein kinase inhibitors for imaging with pet or spect |
| topic | molecular imaging protein kinase small molecules inhibitors positron emission tomography single photon emission computer tomography |
| url | http://www.mdpi.com/1420-3049/15/11/8260/ |
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