P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure

P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure

The mammalian circadian clock drives daily oscillations in physiology and behavior through an autoregulatory transcription feedback loop present in central and peripheral cells. Ablation of the core clock within the endocrine pancreas of adult animals impairs the transcription and splicing of genes...

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Bibliographic Details
Main Authors: Biliana Marcheva, Benjamin J Weidemann, Akihiko Taguchi, Mark Perelis, Kathryn Moynihan Ramsey, Marsha V Newman, Yumiko Kobayashi, Chiaki Omura, Jocelyn E Manning Fox, Haopeng Lin, Patrick E Macdonald, Joseph Bass
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
circadian clock
high-throughput screen
diabetes
ivermectin
purinergic receptor
insulin
Online Access:https://elifesciences.org/articles/75132

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