Locally Injectable Hydrogels for Tumor Immunotherapy
Hydrogel-based local delivery systems provide a good delivery platform for cancer immunotherapy. Injectable hydrogels can directly deliver antitumor drugs to the tumor site to reduce systemic toxicity and achieve low-dose amplification immunotherapy. Therefore, it may overcome the problems of low dr...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/7/4/224 |
| _version_ | 1797504338684280832 |
|---|---|
| author | Xinyi Zhang Xiaonan Guo Yan Wu Jie Gao |
| author_facet | Xinyi Zhang Xiaonan Guo Yan Wu Jie Gao |
| author_sort | Xinyi Zhang |
| collection | DOAJ |
| description | Hydrogel-based local delivery systems provide a good delivery platform for cancer immunotherapy. Injectable hydrogels can directly deliver antitumor drugs to the tumor site to reduce systemic toxicity and achieve low-dose amplification immunotherapy. Therefore, it may overcome the problems of low drug utilization rate and the systemic side effects in cancer immunotherapy through systemic immune drugs, and it provides simple operation and little invasion at the same time. This study aimed to review the research progress of injectable hydrogels in tumor immunotherapy in recent years. Moreover, the local delivery of multiple drugs using injectable hydrogels in tumors is introduced to achieve single immunotherapy, combined chemo-immunotherapy, combined radio-immunotherapy, and photo-immunotherapy. Finally, the application of hydrogels in tumor immunotherapy is summarized, and the challenges and prospects for injectable hydrogels in tumor immunotherapy are proposed. |
| first_indexed | 2024-03-10T04:03:13Z |
| format | Article |
| id | doaj.art-4ba938257a7f440aa20b1aa7514c2512 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-10T04:03:13Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-4ba938257a7f440aa20b1aa7514c25122023-11-23T08:28:12ZengMDPI AGGels2310-28612021-11-017422410.3390/gels7040224Locally Injectable Hydrogels for Tumor ImmunotherapyXinyi Zhang0Xiaonan Guo1Yan Wu2Jie Gao3Institute of Translational Medicine, Shanghai University, Shanghai 200444, ChinaDepartment of Hemangioma and Vascular Malformation, People’s Hospital of Zhengzhou University, Zhengzhou 450003, ChinaDepartment of Biomaterial, College of Life Sciences, Mudanjiang Medical University, Mudanjiang 157011, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai 200444, ChinaHydrogel-based local delivery systems provide a good delivery platform for cancer immunotherapy. Injectable hydrogels can directly deliver antitumor drugs to the tumor site to reduce systemic toxicity and achieve low-dose amplification immunotherapy. Therefore, it may overcome the problems of low drug utilization rate and the systemic side effects in cancer immunotherapy through systemic immune drugs, and it provides simple operation and little invasion at the same time. This study aimed to review the research progress of injectable hydrogels in tumor immunotherapy in recent years. Moreover, the local delivery of multiple drugs using injectable hydrogels in tumors is introduced to achieve single immunotherapy, combined chemo-immunotherapy, combined radio-immunotherapy, and photo-immunotherapy. Finally, the application of hydrogels in tumor immunotherapy is summarized, and the challenges and prospects for injectable hydrogels in tumor immunotherapy are proposed.https://www.mdpi.com/2310-2861/7/4/224injectable hydrogelimmunotherapycancerlocal administrationcombined therapy |
| spellingShingle | Xinyi Zhang Xiaonan Guo Yan Wu Jie Gao Locally Injectable Hydrogels for Tumor Immunotherapy Gels injectable hydrogel immunotherapy cancer local administration combined therapy |
| title | Locally Injectable Hydrogels for Tumor Immunotherapy |
| title_full | Locally Injectable Hydrogels for Tumor Immunotherapy |
| title_fullStr | Locally Injectable Hydrogels for Tumor Immunotherapy |
| title_full_unstemmed | Locally Injectable Hydrogels for Tumor Immunotherapy |
| title_short | Locally Injectable Hydrogels for Tumor Immunotherapy |
| title_sort | locally injectable hydrogels for tumor immunotherapy |
| topic | injectable hydrogel immunotherapy cancer local administration combined therapy |
| url | https://www.mdpi.com/2310-2861/7/4/224 |
| work_keys_str_mv | AT xinyizhang locallyinjectablehydrogelsfortumorimmunotherapy AT xiaonanguo locallyinjectablehydrogelsfortumorimmunotherapy AT yanwu locallyinjectablehydrogelsfortumorimmunotherapy AT jiegao locallyinjectablehydrogelsfortumorimmunotherapy |