Correlation of Adventitial Vasa Vasorum with Intracranial Atherosclerosis: A Postmortem Study
Background and Purpose Vasa vasorum (VV) have been believed to be rare or non-existent in small-caliber intracranial arteries. In a series of human cerebral artery specimens, we identified and examined the distribution of VV in association with co-existing intracranial atherosclerosis. Methods We ob...
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| Format: | Article |
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Korean Stroke Society
2018-09-01
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| Series: | Journal of Stroke |
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| Online Access: | http://www.j-stroke.org/upload/pdf/jos-2018-01263.pdf |
| _version_ | 1818531964172369920 |
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| author | Lu Zheng Wen Jie Yang Chun Bo Niu Hai Lu Zhao Ka Sing Wong Thomas Wai Hong Leung Xiang Yan Chen |
| author_facet | Lu Zheng Wen Jie Yang Chun Bo Niu Hai Lu Zhao Ka Sing Wong Thomas Wai Hong Leung Xiang Yan Chen |
| author_sort | Lu Zheng |
| collection | DOAJ |
| description | Background and Purpose Vasa vasorum (VV) have been believed to be rare or non-existent in small-caliber intracranial arteries. In a series of human cerebral artery specimens, we identified and examined the distribution of VV in association with co-existing intracranial atherosclerosis. Methods We obtained cerebral artery specimens from 32 consecutive autopsies of subjects aged 45 years or above. We scrutinized middle cerebral artery (MCA), vertebral artery (VA), and basilar artery (BA) for the presence of adventitial VV. We described the distribution of VV, and the characteristics of co-existing atherosclerotic lesions. Results Among 157 intracranial arteries, adventitial VV were present in 74 of the 157 specimens (47%), involving MCA (n=13, 18%), BA (n=14, 19%), and VA (n=47, 64%). Although qualitatively these 74 adventitial VV distributed similarly in arteries with or without atherosclerotic lesions (disease-free arteries n=4/8; arteries of pre-atherosclerosis n=17/42; and arteries of progressive atherosclerosis n=53/107), the presence of adventitial VV in intracranial VA was associated with a heavier plaque load (1.72±1.66 mm2 vs. 0.40±0.32 mm2, P<0.001), severer luminal stenosis (25%±21% vs. 12%±9%, P=0.002), higher rate of concentric lesions (79% vs. 36%, P=0.002), and denser intraplaque calcification (44% vs. 0%, P=0.003). Histologically, intracranial VA with VV had a larger diameter (3.40±0.79 mm vs. 2.34±0.58 mm, P<0.001), thicker arterial wall (0.31±0.13 mm vs. 0.23±0.06 mm, P=0.002), and a larger intima-media (0.19±0.09 mm vs. 0.13± 0.04 mm, P=0.003) than VA without VV. Conclusions Our study demonstrated the distribution of adventitial VV within brain vasculature and association between vertebral VV and progressive atherosclerotic lesions with a heavier plaque load and denser intraplaque calcification. |
| first_indexed | 2024-12-11T17:39:20Z |
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| issn | 2287-6391 2287-6405 |
| language | English |
| last_indexed | 2024-12-11T17:39:20Z |
| publishDate | 2018-09-01 |
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| spelling | doaj.art-4bab0a223bcc4a498293bbf1997bf1052022-12-22T00:56:35ZengKorean Stroke SocietyJournal of Stroke2287-63912287-64052018-09-0120334234910.5853/jos.2018.01263245Correlation of Adventitial Vasa Vasorum with Intracranial Atherosclerosis: A Postmortem StudyLu Zheng0Wen Jie Yang1Chun Bo Niu2Hai Lu Zhao3Ka Sing Wong4Thomas Wai Hong Leung5Xiang Yan Chen6 Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong The Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, MD, USA Department of Pathology, China-Japan Union Hospital of Jilin University, Jilin, China Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin, China Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong KongBackground and Purpose Vasa vasorum (VV) have been believed to be rare or non-existent in small-caliber intracranial arteries. In a series of human cerebral artery specimens, we identified and examined the distribution of VV in association with co-existing intracranial atherosclerosis. Methods We obtained cerebral artery specimens from 32 consecutive autopsies of subjects aged 45 years or above. We scrutinized middle cerebral artery (MCA), vertebral artery (VA), and basilar artery (BA) for the presence of adventitial VV. We described the distribution of VV, and the characteristics of co-existing atherosclerotic lesions. Results Among 157 intracranial arteries, adventitial VV were present in 74 of the 157 specimens (47%), involving MCA (n=13, 18%), BA (n=14, 19%), and VA (n=47, 64%). Although qualitatively these 74 adventitial VV distributed similarly in arteries with or without atherosclerotic lesions (disease-free arteries n=4/8; arteries of pre-atherosclerosis n=17/42; and arteries of progressive atherosclerosis n=53/107), the presence of adventitial VV in intracranial VA was associated with a heavier plaque load (1.72±1.66 mm2 vs. 0.40±0.32 mm2, P<0.001), severer luminal stenosis (25%±21% vs. 12%±9%, P=0.002), higher rate of concentric lesions (79% vs. 36%, P=0.002), and denser intraplaque calcification (44% vs. 0%, P=0.003). Histologically, intracranial VA with VV had a larger diameter (3.40±0.79 mm vs. 2.34±0.58 mm, P<0.001), thicker arterial wall (0.31±0.13 mm vs. 0.23±0.06 mm, P=0.002), and a larger intima-media (0.19±0.09 mm vs. 0.13± 0.04 mm, P=0.003) than VA without VV. Conclusions Our study demonstrated the distribution of adventitial VV within brain vasculature and association between vertebral VV and progressive atherosclerotic lesions with a heavier plaque load and denser intraplaque calcification.http://www.j-stroke.org/upload/pdf/jos-2018-01263.pdfatherosclerosisangiogenesisvasa vasorum |
| spellingShingle | Lu Zheng Wen Jie Yang Chun Bo Niu Hai Lu Zhao Ka Sing Wong Thomas Wai Hong Leung Xiang Yan Chen Correlation of Adventitial Vasa Vasorum with Intracranial Atherosclerosis: A Postmortem Study Journal of Stroke atherosclerosis angiogenesis vasa vasorum |
| title | Correlation of Adventitial Vasa Vasorum with Intracranial Atherosclerosis: A Postmortem Study |
| title_full | Correlation of Adventitial Vasa Vasorum with Intracranial Atherosclerosis: A Postmortem Study |
| title_fullStr | Correlation of Adventitial Vasa Vasorum with Intracranial Atherosclerosis: A Postmortem Study |
| title_full_unstemmed | Correlation of Adventitial Vasa Vasorum with Intracranial Atherosclerosis: A Postmortem Study |
| title_short | Correlation of Adventitial Vasa Vasorum with Intracranial Atherosclerosis: A Postmortem Study |
| title_sort | correlation of adventitial vasa vasorum with intracranial atherosclerosis a postmortem study |
| topic | atherosclerosis angiogenesis vasa vasorum |
| url | http://www.j-stroke.org/upload/pdf/jos-2018-01263.pdf |
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