Use of Pentosan Polysulfate in the Local Treatment of Reactive Arthritis in Children
The aim of the study — to examine the efficacy of pentosan polysulfate in the local treatment of reactive arthritis (ReA) in children and to determine its safety. Materials and methods. The study included 56 children aged 5 to 15 years who were treated at the surgical department № 2 of Children’s Mu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Zaslavsky O.Yu.
2016-05-01
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| Series: | Zdorovʹe Rebenka |
| Subjects: | |
| Online Access: | http://childshealth.zaslavsky.com.ua/article/view/76587 |
| Summary: | The aim of the study — to examine the efficacy of pentosan polysulfate in the local treatment of reactive arthritis (ReA) in children and to determine its safety. Materials and methods. The study included 56 children aged 5 to 15 years who were treated at the surgical department № 2 of Children’s Municipal Clinical Hospital № 1 for primary articular syndrome; purulent pathology and rheumatologic diseases were not confirmed in them during examination. In the diagnosis, we have used laboratory methods (complete blood count, urinalysis, determination of C-reactive protein, rheumatoid factor, circulating immune complexes, seromucoid, ASLO), electrocardiography, ultrasound investigation (UI) of the abdominal organs. All children were consulted by a cardiologist. In some cases, radiography and joint puncture were conducted. Also, all patients underwent UI of the affected joints on the LogiQ-5 device with gauges from 7.5 to 10.5 MHz. To study the action of this drug, we allocated 2 groups: the main (27 people), in which in addition to basic therapy, Thrombocid gel was applied topically, and control one (29 persons), identical in age and sex with the main group, in which we used only basic therapy. Evaluating the effectiveness of pentosan polysulphate (Thrombocid) was based on the dynamics of local manifestations and ultrasound picture of the affected joints, determined on days 3, 5 and 7. Research results. It was revealed that a in few weeks, the appearance of ReA was preceded by the following factors: acute respiratory disease (63 %), diarrhea (2 %), trauma (6 %), in the rest (29 %) of patients, possible causal factors have not been detected. By the number of affected joints at the onset of ReA, mainly monoarthritis (52 children — 93 %) has been diagnosed, oligoarthritis (2 — 3.5%) and symmetrical joint disease (2 — 3.5 %) occurred rarely. In ReA, the disease most often manifested by arthritis of the knee (60.47 ± 3.28 %) or hip (34.14 ± 2.35 %) joints. Rarely, ankle joint (4.32 ± 2.32 %) has been affected first. Swelling of joints in the half of patients (55.10 ± 7.11 %) was moderate, in the quarter (22.80 ± 2.09 %) — significant, in the rest of them, swelling was not observed or was minimal. 58.26 ± 8.23 % of children had local hyperthermia. Dynamics of the local changes and ultrasound picture shows a pronounced positive effect and acceleration of recovery in the group with the topical use of Thrombocid gel. Conclusions. Application of pentosan polysulfate in the comprehensive treatment of ReA accelerates the regression of local articular manifestations, promotes early activation of patients due to the early elimination of pain syndrome and accelerates the recovery. The use of this drug is safe in childhood. |
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| ISSN: | 2224-0551 2307-1168 |