The association of heat shock protein genetic polymorphisms with age-related hearing impairment in Taiwan
Abstract Background Age-related hearing impairment (ARHI) is a major disability among the elderly population. Heat shock proteins (HSPs) were found to be associated with ARHI in animal studies. The aim of this study was to analyze the associations of single nucleotide polymorphisms (SNPs) of HSP gen...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40463-021-00512-2 |
| _version_ | 1797965119073812480 |
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| author | Ning-Chia Chang Hua-Ling Yang Chia-Yen Dai Wen-Yi Lin Meng-Hsuen Hsieh Chen-Yu Chien Kuen-Yao Ho |
| author_facet | Ning-Chia Chang Hua-Ling Yang Chia-Yen Dai Wen-Yi Lin Meng-Hsuen Hsieh Chen-Yu Chien Kuen-Yao Ho |
| author_sort | Ning-Chia Chang |
| collection | DOAJ |
| description | Abstract Background Age-related hearing impairment (ARHI) is a major disability among the elderly population. Heat shock proteins (HSPs) were found to be associated with ARHI in animal studies. The aim of this study was to analyze the associations of single nucleotide polymorphisms (SNPs) of HSP genes with ARHI in an elderly population in Taiwan. Methods Participants ≥65 years of age were recruited for audiometric tests and genetic analyses. The pure tone average (PTA) of the better hearing ear was calculated for ARHI evaluation. The associations of HSPA1L (rs2075800 and rs2227956), HSPA1A (rs1043618) and HSPA1B (rs2763979) with ARHI were analyzed in 146 ARHI-susceptible (cases) and 146 ARHI-resistant (controls) participants. Results The “T” allele of HSPA1B rs2763979 showed a decreased risk of ARHI. The “TT” genotype of rs2763979 also showed a decreased risk of ARHI in the dominant hereditary model. For HSPA1L (rs2075800 and rs2227956) and HSPA1A (rs1043618), the haplotype “CAG” was related to a decreased risk of ARHI. Conclusion These findings suggest that HSP70 polymorphisms are associated with susceptibility to ARHI in the elderly population. Graphical abstract |
| first_indexed | 2024-04-11T01:53:59Z |
| format | Article |
| id | doaj.art-4baca7abb7ae4bf4a04f737aedfdaeee |
| institution | Directory Open Access Journal |
| issn | 1916-0216 |
| language | English |
| last_indexed | 2024-04-11T01:53:59Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj.art-4baca7abb7ae4bf4a04f737aedfdaeee2023-01-03T05:32:24ZengBMCJournal of Otolaryngology - Head and Neck Surgery1916-02162021-04-015011710.1186/s40463-021-00512-2The association of heat shock protein genetic polymorphisms with age-related hearing impairment in TaiwanNing-Chia Chang0Hua-Ling Yang1Chia-Yen Dai2Wen-Yi Lin3Meng-Hsuen Hsieh4Chen-Yu Chien5Kuen-Yao Ho6Department of Otorhinolaryngology, School of Medicine, College of Medicine, Kaohsiung Medical UniversityDepartment of Internal Medicine, Division of Hepatobiliary and Pancreatic Medicine, Kaohsiung Medical University HospitalDepartment of Internal Medicine, Division of Hepatobiliary and Pancreatic Medicine, Kaohsiung Medical University HospitalHealth Management Center, Kaohsiung Municipal Siaogang HospitalDepartment of Internal Medicine, Division of Hepatobiliary and Pancreatic Medicine, Kaohsiung Medical University HospitalDepartment of Otorhinolaryngology, School of Medicine, College of Medicine, Kaohsiung Medical UniversityDepartment of Otorhinolaryngology, School of Medicine, College of Medicine, Kaohsiung Medical UniversityAbstract Background Age-related hearing impairment (ARHI) is a major disability among the elderly population. Heat shock proteins (HSPs) were found to be associated with ARHI in animal studies. The aim of this study was to analyze the associations of single nucleotide polymorphisms (SNPs) of HSP genes with ARHI in an elderly population in Taiwan. Methods Participants ≥65 years of age were recruited for audiometric tests and genetic analyses. The pure tone average (PTA) of the better hearing ear was calculated for ARHI evaluation. The associations of HSPA1L (rs2075800 and rs2227956), HSPA1A (rs1043618) and HSPA1B (rs2763979) with ARHI were analyzed in 146 ARHI-susceptible (cases) and 146 ARHI-resistant (controls) participants. Results The “T” allele of HSPA1B rs2763979 showed a decreased risk of ARHI. The “TT” genotype of rs2763979 also showed a decreased risk of ARHI in the dominant hereditary model. For HSPA1L (rs2075800 and rs2227956) and HSPA1A (rs1043618), the haplotype “CAG” was related to a decreased risk of ARHI. Conclusion These findings suggest that HSP70 polymorphisms are associated with susceptibility to ARHI in the elderly population. Graphical abstracthttps://doi.org/10.1186/s40463-021-00512-2Age-related hearing impairmentHeat shock proteinSingle nucleotide polymorphism |
| spellingShingle | Ning-Chia Chang Hua-Ling Yang Chia-Yen Dai Wen-Yi Lin Meng-Hsuen Hsieh Chen-Yu Chien Kuen-Yao Ho The association of heat shock protein genetic polymorphisms with age-related hearing impairment in Taiwan Journal of Otolaryngology - Head and Neck Surgery Age-related hearing impairment Heat shock protein Single nucleotide polymorphism |
| title | The association of heat shock protein genetic polymorphisms with age-related hearing impairment in Taiwan |
| title_full | The association of heat shock protein genetic polymorphisms with age-related hearing impairment in Taiwan |
| title_fullStr | The association of heat shock protein genetic polymorphisms with age-related hearing impairment in Taiwan |
| title_full_unstemmed | The association of heat shock protein genetic polymorphisms with age-related hearing impairment in Taiwan |
| title_short | The association of heat shock protein genetic polymorphisms with age-related hearing impairment in Taiwan |
| title_sort | association of heat shock protein genetic polymorphisms with age related hearing impairment in taiwan |
| topic | Age-related hearing impairment Heat shock protein Single nucleotide polymorphism |
| url | https://doi.org/10.1186/s40463-021-00512-2 |
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