Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila
Both intrinsic and external signals regulate stem cell fate. Here, the authors perform a genome-wide RNAi screen to identify regulators of testis germline stem cells (GSC) in Drosophila, finding more than half of the genes were external regulators and heterochromatin/cytokinesis proteins mediated GS...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12149 |
| _version_ | 1818855776523911168 |
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| author | Ying Liu Qinglan Ge Brian Chan Hanhan Liu Shree Ram Singh Jacob Manley Jae Lee Ann Marie Weideman Gerald Hou Steven X. Hou |
| author_facet | Ying Liu Qinglan Ge Brian Chan Hanhan Liu Shree Ram Singh Jacob Manley Jae Lee Ann Marie Weideman Gerald Hou Steven X. Hou |
| author_sort | Ying Liu |
| collection | DOAJ |
| description | Both intrinsic and external signals regulate stem cell fate. Here, the authors perform a genome-wide RNAi screen to identify regulators of testis germline stem cells (GSC) in Drosophila, finding more than half of the genes were external regulators and heterochromatin/cytokinesis proteins mediated GSC fate. |
| first_indexed | 2024-12-19T08:13:59Z |
| format | Article |
| id | doaj.art-4bacdc24e3e94f74b5fe7c8b9d8f0369 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:13:59Z |
| publishDate | 2016-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4bacdc24e3e94f74b5fe7c8b9d8f03692022-12-21T20:29:33ZengNature PortfolioNature Communications2041-17232016-08-017111110.1038/ncomms12149Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in DrosophilaYing Liu0Qinglan Ge1Brian Chan2Hanhan Liu3Shree Ram Singh4Jacob Manley5Jae Lee6Ann Marie Weideman7Gerald Hou8Steven X. Hou9Basic Research Laboratory, National Cancer Institute at Frederick, National Institutes of HealthBasic Research Laboratory, National Cancer Institute at Frederick, National Institutes of HealthBasic Research Laboratory, National Cancer Institute at Frederick, National Institutes of HealthBasic Research Laboratory, National Cancer Institute at Frederick, National Institutes of HealthBasic Research Laboratory, National Cancer Institute at Frederick, National Institutes of HealthBasic Research Laboratory, National Cancer Institute at Frederick, National Institutes of HealthBasic Research Laboratory, National Cancer Institute at Frederick, National Institutes of HealthBasic Research Laboratory, National Cancer Institute at Frederick, National Institutes of HealthBasic Research Laboratory, National Cancer Institute at Frederick, National Institutes of HealthBasic Research Laboratory, National Cancer Institute at Frederick, National Institutes of HealthBoth intrinsic and external signals regulate stem cell fate. Here, the authors perform a genome-wide RNAi screen to identify regulators of testis germline stem cells (GSC) in Drosophila, finding more than half of the genes were external regulators and heterochromatin/cytokinesis proteins mediated GSC fate.https://doi.org/10.1038/ncomms12149 |
| spellingShingle | Ying Liu Qinglan Ge Brian Chan Hanhan Liu Shree Ram Singh Jacob Manley Jae Lee Ann Marie Weideman Gerald Hou Steven X. Hou Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila Nature Communications |
| title | Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila |
| title_full | Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila |
| title_fullStr | Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila |
| title_full_unstemmed | Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila |
| title_short | Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila |
| title_sort | whole animal genome wide rnai screen identifies networks regulating male germline stem cells in drosophila |
| url | https://doi.org/10.1038/ncomms12149 |
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