The Effect of Conjugated Linoleic Acid Supplementation on Densitometric Parameters in Overweight and Obese Women—A Randomised Controlled Trial
<i>Background and Objectives</i>: Conjugated linoleic acid (CLA) can improve bone health in animals, yet the effects on humans have not been consistent. Therefore, this parallel randomised controlled trial aimed to assess the effect of CLA supplementation on bone mineral density (BMD) an...
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MDPI AG
2023-09-01
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| Online Access: | https://www.mdpi.com/1648-9144/59/9/1690 |
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| author | Małgorzata Jamka Agata Czochralska-Duszyńska Edyta Mądry Aleksandra Lisowska Katarzyna Jończyk-Potoczna Judyta Cielecka-Piontek Paweł Bogdański Jarosław Walkowiak |
| author_facet | Małgorzata Jamka Agata Czochralska-Duszyńska Edyta Mądry Aleksandra Lisowska Katarzyna Jończyk-Potoczna Judyta Cielecka-Piontek Paweł Bogdański Jarosław Walkowiak |
| author_sort | Małgorzata Jamka |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Conjugated linoleic acid (CLA) can improve bone health in animals, yet the effects on humans have not been consistent. Therefore, this parallel randomised controlled trial aimed to assess the effect of CLA supplementation on bone mineral density (BMD) and content (BMC) in overweight or obese women. <i>Materials and Methods</i>: The study population included 74 women who were divided into the CLA (<i>n</i> = 37) and control (<i>n</i> = 37) groups. The CLA group received six capsules per day containing approximately 3 g of cis-9, trans-11 and trans-10, cis-12 CLA isomers in a 50:50 ratio. The control group received the same number of placebo capsules that contained sunflower oil. BMC and BMD at total body, lumbar spine (L1–L4), and femoral neck were measured before and after a three-month intervention. <i>Results</i>: The comparison of BMC and BMD for the total body, lumbar spine (L1–L4), and femoral neck before and after the intervention showed no differences between the groups. However, a within-group analysis demonstrated a significant increase in BMC (<i>p</i> = 0.0100) and BMD (<i>p</i> = 0.0397) at lumbar spine (L1–L4) in the CLA group. Nevertheless, there were no significant differences between the CLA and placebo groups in changes in all analysed densitometric parameters. <i>Conclusions</i>: Altogether, three-month CLA supplementation in overweight and obese women did not improve bone health, although the short intervention period could have limited our findings, long-term intervention studies are needed. The study protocol was registered in the German Clinical Trials Register database (ID: DRKS00010462, date of registration: 4 May 2016). |
| first_indexed | 2024-03-10T22:28:55Z |
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| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T22:28:55Z |
| publishDate | 2023-09-01 |
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| spelling | doaj.art-4bad3027afe64145bc99b10d1bbc9d9c2023-11-19T11:53:32ZengMDPI AGMedicina1010-660X1648-91442023-09-01599169010.3390/medicina59091690The Effect of Conjugated Linoleic Acid Supplementation on Densitometric Parameters in Overweight and Obese Women—A Randomised Controlled TrialMałgorzata Jamka0Agata Czochralska-Duszyńska1Edyta Mądry2Aleksandra Lisowska3Katarzyna Jończyk-Potoczna4Judyta Cielecka-Piontek5Paweł Bogdański6Jarosław Walkowiak7Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, PolandDepartment of Physiology, Poznan University of Medical Sciences, Święcickiego Str. 6, 61-781 Poznań, PolandDepartment of Physiology, Poznan University of Medical Sciences, Święcickiego Str. 6, 61-781 Poznań, PolandDepartment of Pediatric Diabetes, Auxology and Obesity, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, PolandDepartment of Pediatric Radiology, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, PolandDepartment of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka Str. 3, 60-806 Poznań, PolandDepartment of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego Str. 84, 60-569 Poznań, PolandDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, Poland<i>Background and Objectives</i>: Conjugated linoleic acid (CLA) can improve bone health in animals, yet the effects on humans have not been consistent. Therefore, this parallel randomised controlled trial aimed to assess the effect of CLA supplementation on bone mineral density (BMD) and content (BMC) in overweight or obese women. <i>Materials and Methods</i>: The study population included 74 women who were divided into the CLA (<i>n</i> = 37) and control (<i>n</i> = 37) groups. The CLA group received six capsules per day containing approximately 3 g of cis-9, trans-11 and trans-10, cis-12 CLA isomers in a 50:50 ratio. The control group received the same number of placebo capsules that contained sunflower oil. BMC and BMD at total body, lumbar spine (L1–L4), and femoral neck were measured before and after a three-month intervention. <i>Results</i>: The comparison of BMC and BMD for the total body, lumbar spine (L1–L4), and femoral neck before and after the intervention showed no differences between the groups. However, a within-group analysis demonstrated a significant increase in BMC (<i>p</i> = 0.0100) and BMD (<i>p</i> = 0.0397) at lumbar spine (L1–L4) in the CLA group. Nevertheless, there were no significant differences between the CLA and placebo groups in changes in all analysed densitometric parameters. <i>Conclusions</i>: Altogether, three-month CLA supplementation in overweight and obese women did not improve bone health, although the short intervention period could have limited our findings, long-term intervention studies are needed. The study protocol was registered in the German Clinical Trials Register database (ID: DRKS00010462, date of registration: 4 May 2016).https://www.mdpi.com/1648-9144/59/9/1690bone mineral contentbone mineral densitydensitometryobesity |
| spellingShingle | Małgorzata Jamka Agata Czochralska-Duszyńska Edyta Mądry Aleksandra Lisowska Katarzyna Jończyk-Potoczna Judyta Cielecka-Piontek Paweł Bogdański Jarosław Walkowiak The Effect of Conjugated Linoleic Acid Supplementation on Densitometric Parameters in Overweight and Obese Women—A Randomised Controlled Trial Medicina bone mineral content bone mineral density densitometry obesity |
| title | The Effect of Conjugated Linoleic Acid Supplementation on Densitometric Parameters in Overweight and Obese Women—A Randomised Controlled Trial |
| title_full | The Effect of Conjugated Linoleic Acid Supplementation on Densitometric Parameters in Overweight and Obese Women—A Randomised Controlled Trial |
| title_fullStr | The Effect of Conjugated Linoleic Acid Supplementation on Densitometric Parameters in Overweight and Obese Women—A Randomised Controlled Trial |
| title_full_unstemmed | The Effect of Conjugated Linoleic Acid Supplementation on Densitometric Parameters in Overweight and Obese Women—A Randomised Controlled Trial |
| title_short | The Effect of Conjugated Linoleic Acid Supplementation on Densitometric Parameters in Overweight and Obese Women—A Randomised Controlled Trial |
| title_sort | effect of conjugated linoleic acid supplementation on densitometric parameters in overweight and obese women a randomised controlled trial |
| topic | bone mineral content bone mineral density densitometry obesity |
| url | https://www.mdpi.com/1648-9144/59/9/1690 |
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