Obesity as disruptor of the female fertility
Abstract Both obesity and overweight are increasing worldwide and have detrimental influences on several human body functions including the reproductive health. In particular, obese women undergo perturbations of the ‘hypothalamic pituitary ovarian axis’, and frequently suffer of menstrual dysfuncti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-03-01
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| Series: | Reproductive Biology and Endocrinology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12958-018-0336-z |
| _version_ | 1818041696664944640 |
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| author | Erica Silvestris Giovanni de Pergola Raffaele Rosania Giuseppe Loverro |
| author_facet | Erica Silvestris Giovanni de Pergola Raffaele Rosania Giuseppe Loverro |
| author_sort | Erica Silvestris |
| collection | DOAJ |
| description | Abstract Both obesity and overweight are increasing worldwide and have detrimental influences on several human body functions including the reproductive health. In particular, obese women undergo perturbations of the ‘hypothalamic pituitary ovarian axis’, and frequently suffer of menstrual dysfunction leading to anovulation and infertility. Besides the hormone disorders and subfertility that are common in the polycystic ovary syndrome (PCOS), in obesity the adipocytes act as endocrine organ. The adipose tissue indeed, releases a number of bioactive molecules, namely adipokines, that variably interact with multiple molecular pathways of insulin resistance, inflammation, hypertension, cardiovascular risk, coagulation, and oocyte differentiation and maturation. Moreover, endometrial implantation and other reproductive functions are affected in obese women with complications including delayed conceptions, increased miscarriage rate, reduced outcomes in assisted conception treatments. On the contrary, weight loss programs through lifestyle modification in obese women, have been proven to restore menstrual cyclicity and ovulation and improve the likelihood of conception. |
| first_indexed | 2024-12-10T08:34:32Z |
| format | Article |
| id | doaj.art-4bad44b8ec494128a10d5934a2d14fa0 |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-12-10T08:34:32Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-4bad44b8ec494128a10d5934a2d14fa02022-12-22T01:56:01ZengBMCReproductive Biology and Endocrinology1477-78272018-03-0116111310.1186/s12958-018-0336-zObesity as disruptor of the female fertilityErica Silvestris0Giovanni de Pergola1Raffaele Rosania2Giuseppe Loverro3Interdisciplinary Department of Medicine, Section of Obstetrics and Gynecology, University of Bari Aldo MoroDepartmentof Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Aldo MoroInterdisciplinary Department of Medicine, Section of Obstetrics and Gynecology, University of Bari Aldo MoroInterdisciplinary Department of Medicine, Section of Obstetrics and Gynecology, University of Bari Aldo MoroAbstract Both obesity and overweight are increasing worldwide and have detrimental influences on several human body functions including the reproductive health. In particular, obese women undergo perturbations of the ‘hypothalamic pituitary ovarian axis’, and frequently suffer of menstrual dysfunction leading to anovulation and infertility. Besides the hormone disorders and subfertility that are common in the polycystic ovary syndrome (PCOS), in obesity the adipocytes act as endocrine organ. The adipose tissue indeed, releases a number of bioactive molecules, namely adipokines, that variably interact with multiple molecular pathways of insulin resistance, inflammation, hypertension, cardiovascular risk, coagulation, and oocyte differentiation and maturation. Moreover, endometrial implantation and other reproductive functions are affected in obese women with complications including delayed conceptions, increased miscarriage rate, reduced outcomes in assisted conception treatments. On the contrary, weight loss programs through lifestyle modification in obese women, have been proven to restore menstrual cyclicity and ovulation and improve the likelihood of conception.http://link.springer.com/article/10.1186/s12958-018-0336-zObesityInfertilityAdipokinesAnovulationOocytes |
| spellingShingle | Erica Silvestris Giovanni de Pergola Raffaele Rosania Giuseppe Loverro Obesity as disruptor of the female fertility Reproductive Biology and Endocrinology Obesity Infertility Adipokines Anovulation Oocytes |
| title | Obesity as disruptor of the female fertility |
| title_full | Obesity as disruptor of the female fertility |
| title_fullStr | Obesity as disruptor of the female fertility |
| title_full_unstemmed | Obesity as disruptor of the female fertility |
| title_short | Obesity as disruptor of the female fertility |
| title_sort | obesity as disruptor of the female fertility |
| topic | Obesity Infertility Adipokines Anovulation Oocytes |
| url | http://link.springer.com/article/10.1186/s12958-018-0336-z |
| work_keys_str_mv | AT ericasilvestris obesityasdisruptorofthefemalefertility AT giovannidepergola obesityasdisruptorofthefemalefertility AT raffaelerosania obesityasdisruptorofthefemalefertility AT giuseppeloverro obesityasdisruptorofthefemalefertility |