Quality Assessment and Relevant Clinical Impact of Randomized Controlled Trials of Varicocele: Next Step to Good-Quality Randomized Controlled Trial of Varicocele Treatment
Purpose: To assess the quality of randomized controlled trials (RCTs) on varicocele published from 1979 to 2017. Materials and Methods: We searched for original RCT on varicocele published between 1979 and 2017. Jadad scale, van Tulder scale, and Cochrane Collaboration Risk of Bias Tool were used...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Sexual Medicine and Andrology
2022-04-01
|
| Series: | The World Journal of Men's Health |
| Subjects: |
| _version_ | 1818774594247458816 |
|---|---|
| author | Kyu Shik Kim Jae Hoon Chung Hyung Joon Park Woo Jong Shin Bum Hyun Lee Seung Wook Lee |
| author_facet | Kyu Shik Kim Jae Hoon Chung Hyung Joon Park Woo Jong Shin Bum Hyun Lee Seung Wook Lee |
| author_sort | Kyu Shik Kim |
| collection | DOAJ |
| description | Purpose: To assess the quality of randomized controlled trials (RCTs) on varicocele published from 1979 to 2017.
Materials and Methods: We searched for original RCT on varicocele published between 1979 and 2017. Jadad scale, van Tulder
scale, and Cochrane Collaboration Risk of Bias Tool were used to analyze RCT quality over time. Effects on RCT quality
including funding source, Institutional Review Board (IRB) approval, and intervention were assessed. Treatment parameters of
varicocele were also analyzed.
Results: Blinding and allocation concealment were described in 25.9% and 9.4% of RCT, respectively. Both tended to increase
and a sharp dip in allocation concealment was observed in 2010–2017. Jadad scores increased steadily from 1979 to
2017 (1.28±0.59 to 2.19±1.10, p<0.01). Van Tulder scores tended to increase from 1979 to 2017 (4.21±0.94 to 5.58±1.58,
p<0.01). RCTs with funding statements had higher Jadad (Yes vs. No, 3.25±0.50 vs. 1.70±0.97; p<0.01) and van Tulder (Yes
vs. No, 7.25±1.26 vs. 4.81±1.26; p<0.01) scores than unfunded RCTs. IRB approval and intervention were associated with
better quality.
Conclusions: The number of RCTs on varicocele increased from 1979 to 2017. Also, quality improved over time with increasing
IRB approval, funding, and multicenter trial. Most RCTs on varicocele reported the use of surgical treatment. RCTs
of surgical treatments have limitations to satisfy the condition of RCT to conduct, but their quality has improved over time. |
| first_indexed | 2024-12-18T10:43:37Z |
| format | Article |
| id | doaj.art-4baeb1de853446e6ab2fd6e00203cd49 |
| institution | Directory Open Access Journal |
| issn | 2287-4208 2287-4690 |
| language | English |
| last_indexed | 2024-12-18T10:43:37Z |
| publishDate | 2022-04-01 |
| publisher | Korean Society for Sexual Medicine and Andrology |
| record_format | Article |
| series | The World Journal of Men's Health |
| spelling | doaj.art-4baeb1de853446e6ab2fd6e00203cd492022-12-21T21:10:35ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902022-04-0140229029810.5534/wjmh.200167Quality Assessment and Relevant Clinical Impact of Randomized Controlled Trials of Varicocele: Next Step to Good-Quality Randomized Controlled Trial of Varicocele TreatmentKyu Shik Kim0https://orcid.org/0000-0001-8755-0774Jae Hoon Chung1https://orcid.org/0000-0002-9729-3457Hyung Joon Park2https://orcid.org/0000-0002-3114-5355Woo Jong Shin3https://orcid.org/0000-0002-3786-2267Bum Hyun Lee4https://orcid.org/0000-0001-5286-5768Seung Wook Lee5https://orcid.org/0000-0002-7602-7977Hanyang University College of MedicineSungkyunkwan University School of Medicine, SeoulHanyang University College of Medicine, GuriHanyang University College of Medicine, GuriSungkyul University College of Engineering, AnyangHanyang University College of MedicinePurpose: To assess the quality of randomized controlled trials (RCTs) on varicocele published from 1979 to 2017. Materials and Methods: We searched for original RCT on varicocele published between 1979 and 2017. Jadad scale, van Tulder scale, and Cochrane Collaboration Risk of Bias Tool were used to analyze RCT quality over time. Effects on RCT quality including funding source, Institutional Review Board (IRB) approval, and intervention were assessed. Treatment parameters of varicocele were also analyzed. Results: Blinding and allocation concealment were described in 25.9% and 9.4% of RCT, respectively. Both tended to increase and a sharp dip in allocation concealment was observed in 2010–2017. Jadad scores increased steadily from 1979 to 2017 (1.28±0.59 to 2.19±1.10, p<0.01). Van Tulder scores tended to increase from 1979 to 2017 (4.21±0.94 to 5.58±1.58, p<0.01). RCTs with funding statements had higher Jadad (Yes vs. No, 3.25±0.50 vs. 1.70±0.97; p<0.01) and van Tulder (Yes vs. No, 7.25±1.26 vs. 4.81±1.26; p<0.01) scores than unfunded RCTs. IRB approval and intervention were associated with better quality. Conclusions: The number of RCTs on varicocele increased from 1979 to 2017. Also, quality improved over time with increasing IRB approval, funding, and multicenter trial. Most RCTs on varicocele reported the use of surgical treatment. RCTs of surgical treatments have limitations to satisfy the condition of RCT to conduct, but their quality has improved over time.consort statementrandomized control trialreporting qualityvaricocele |
| spellingShingle | Kyu Shik Kim Jae Hoon Chung Hyung Joon Park Woo Jong Shin Bum Hyun Lee Seung Wook Lee Quality Assessment and Relevant Clinical Impact of Randomized Controlled Trials of Varicocele: Next Step to Good-Quality Randomized Controlled Trial of Varicocele Treatment The World Journal of Men's Health consort statement randomized control trial reporting quality varicocele |
| title | Quality Assessment and Relevant Clinical Impact of Randomized Controlled Trials of Varicocele: Next Step to Good-Quality Randomized Controlled Trial of Varicocele Treatment |
| title_full | Quality Assessment and Relevant Clinical Impact of Randomized Controlled Trials of Varicocele: Next Step to Good-Quality Randomized Controlled Trial of Varicocele Treatment |
| title_fullStr | Quality Assessment and Relevant Clinical Impact of Randomized Controlled Trials of Varicocele: Next Step to Good-Quality Randomized Controlled Trial of Varicocele Treatment |
| title_full_unstemmed | Quality Assessment and Relevant Clinical Impact of Randomized Controlled Trials of Varicocele: Next Step to Good-Quality Randomized Controlled Trial of Varicocele Treatment |
| title_short | Quality Assessment and Relevant Clinical Impact of Randomized Controlled Trials of Varicocele: Next Step to Good-Quality Randomized Controlled Trial of Varicocele Treatment |
| title_sort | quality assessment and relevant clinical impact of randomized controlled trials of varicocele next step to good quality randomized controlled trial of varicocele treatment |
| topic | consort statement randomized control trial reporting quality varicocele |
| work_keys_str_mv | AT kyushikkim qualityassessmentandrelevantclinicalimpactofrandomizedcontrolledtrialsofvaricocelenextsteptogoodqualityrandomizedcontrolledtrialofvaricoceletreatment AT jaehoonchung qualityassessmentandrelevantclinicalimpactofrandomizedcontrolledtrialsofvaricocelenextsteptogoodqualityrandomizedcontrolledtrialofvaricoceletreatment AT hyungjoonpark qualityassessmentandrelevantclinicalimpactofrandomizedcontrolledtrialsofvaricocelenextsteptogoodqualityrandomizedcontrolledtrialofvaricoceletreatment AT woojongshin qualityassessmentandrelevantclinicalimpactofrandomizedcontrolledtrialsofvaricocelenextsteptogoodqualityrandomizedcontrolledtrialofvaricoceletreatment AT bumhyunlee qualityassessmentandrelevantclinicalimpactofrandomizedcontrolledtrialsofvaricocelenextsteptogoodqualityrandomizedcontrolledtrialofvaricoceletreatment AT seungwooklee qualityassessmentandrelevantclinicalimpactofrandomizedcontrolledtrialsofvaricocelenextsteptogoodqualityrandomizedcontrolledtrialofvaricoceletreatment |