Strikingly different effects of cholesterol and 7-ketocholesterol on lipid bilayer-mediated aggregation of amyloid beta (1-42)

Strikingly different effects of cholesterol and 7-ketocholesterol on lipid bilayer-mediated aggregation of amyloid beta (1-42)

Oxidized cholesterol has been widely reported to contribute to the pathogenesis of Alzheimer's disease (AD). However, the mechanism by which they affect the disease is not fully understood. Herein, we aimed to investigate the effect of 7-ketocholesterol (7keto) on membrane-mediated aggregation...

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Bibliographic Details
Main Authors: Huong T.T. Phan, Naofumi Shimokawa, Neha Sharma, Masahiro Takagi, Mun'delanji C. Vestergaard
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Cholesterol
7-ketocholesterol
Amyloid beta aggregation
Membranes
Lipid vesicles
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580817302686

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