Brain Structure Alterations in Poly-Drug Use: Reduced Cortical Thickness and White Matter Impairments in Regions Associated With Affective, Cognitive, and Motor Functions
Substance use disorders (SUDs) are defined by obsessive and uncontrolled consumption, which is related to neurobiological changes. Based on previous work, this study investigated potential alterations in brain structure in poly-drug use disordered (PUD) patients in comparison to controls from the no...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-09-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00667/full |
| _version_ | 1828393276312387584 |
|---|---|
| author | Human F. Unterrainer Human F. Unterrainer Human F. Unterrainer Michaela Hiebler-Ragger Michaela Hiebler-Ragger Karl Koschutnig Jürgen Fuchshuber Jürgen Fuchshuber Klemens Ragger Klemens Ragger Corinna M. Perchtold Ilona Papousek Elisabeth M. Weiss Andreas Fink |
| author_facet | Human F. Unterrainer Human F. Unterrainer Human F. Unterrainer Michaela Hiebler-Ragger Michaela Hiebler-Ragger Karl Koschutnig Jürgen Fuchshuber Jürgen Fuchshuber Klemens Ragger Klemens Ragger Corinna M. Perchtold Ilona Papousek Elisabeth M. Weiss Andreas Fink |
| author_sort | Human F. Unterrainer |
| collection | DOAJ |
| description | Substance use disorders (SUDs) are defined by obsessive and uncontrolled consumption, which is related to neurobiological changes. Based on previous work, this study investigated potential alterations in brain structure in poly-drug use disordered (PUD) patients in comparison to controls from the normal population. This study involved a sample of 153 right-handed men aged between 18 and 41 years, comprising a clinical group of 78 PUD and a group of 75 healthy controls. Group differences in gray matter (GM) and white matter (WM), as well as cortical thickness (CT), were investigated by means of diffusion tensor imaging using automated fiber quantification (AFQ) and voxel-based morphometry. We observed significant WM impairments in PUD, especially in the bilateral corticospinal tracts and the inferior longitudinal fasciculi. Furthermore, we found reduced CT in the PUD group especially in the left insular and left lateral orbitofrontal cortex. There were no group differences in GM. In addition, PUD exhibited a higher amount of psychiatric symptoms (Brief Symptom Inventory) and impairments in cognitive functions (Wonderlic Personnel Test). In line with previous research, this study revealed substantial impairments in brain structure in the PUD group in areas linked with affective, cognitive, and motor functions. We therefore hypothesize a neurologically informed treatment approach for SUD. Future studies should consequently explore a potential positive neuroplasticity in relation to a better therapeutic outcome. |
| first_indexed | 2024-12-10T07:36:12Z |
| format | Article |
| id | doaj.art-4bb27bce1e36447f950753f5760164c6 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-10T07:36:12Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-4bb27bce1e36447f950753f5760164c62022-12-22T01:57:25ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-09-011010.3389/fpsyt.2019.00667451394Brain Structure Alterations in Poly-Drug Use: Reduced Cortical Thickness and White Matter Impairments in Regions Associated With Affective, Cognitive, and Motor FunctionsHuman F. Unterrainer0Human F. Unterrainer1Human F. Unterrainer2Michaela Hiebler-Ragger3Michaela Hiebler-Ragger4Karl Koschutnig5Jürgen Fuchshuber6Jürgen Fuchshuber7Klemens Ragger8Klemens Ragger9Corinna M. Perchtold10Ilona Papousek11Elisabeth M. Weiss12Andreas Fink13Center for Integrative Addiction Research (CIAR), Grüner Kreis Society, Vienna, AustriaUniversity Clinic for Psychiatry and Psychotherapeutic Medicine, Medical University Graz, Graz, AustriaInstitute for Religious Studies, University of Vienna, Vienna, AustriaCenter for Integrative Addiction Research (CIAR), Grüner Kreis Society, Vienna, AustriaUniversity Clinic for Psychiatry and Psychotherapeutic Medicine, Medical University Graz, Graz, AustriaInstitute of Psychology, University of Graz, Graz, AustriaCenter for Integrative Addiction Research (CIAR), Grüner Kreis Society, Vienna, AustriaUniversity Clinic for Psychiatry and Psychotherapeutic Medicine, Medical University Graz, Graz, AustriaCenter for Integrative Addiction Research (CIAR), Grüner Kreis Society, Vienna, AustriaUniversity Clinic for Psychiatry and Psychotherapeutic Medicine, Medical University Graz, Graz, AustriaInstitute of Psychology, University of Graz, Graz, AustriaInstitute of Psychology, University of Graz, Graz, AustriaInstitute of Psychology, University of Graz, Graz, AustriaInstitute of Psychology, University of Graz, Graz, AustriaSubstance use disorders (SUDs) are defined by obsessive and uncontrolled consumption, which is related to neurobiological changes. Based on previous work, this study investigated potential alterations in brain structure in poly-drug use disordered (PUD) patients in comparison to controls from the normal population. This study involved a sample of 153 right-handed men aged between 18 and 41 years, comprising a clinical group of 78 PUD and a group of 75 healthy controls. Group differences in gray matter (GM) and white matter (WM), as well as cortical thickness (CT), were investigated by means of diffusion tensor imaging using automated fiber quantification (AFQ) and voxel-based morphometry. We observed significant WM impairments in PUD, especially in the bilateral corticospinal tracts and the inferior longitudinal fasciculi. Furthermore, we found reduced CT in the PUD group especially in the left insular and left lateral orbitofrontal cortex. There were no group differences in GM. In addition, PUD exhibited a higher amount of psychiatric symptoms (Brief Symptom Inventory) and impairments in cognitive functions (Wonderlic Personnel Test). In line with previous research, this study revealed substantial impairments in brain structure in the PUD group in areas linked with affective, cognitive, and motor functions. We therefore hypothesize a neurologically informed treatment approach for SUD. Future studies should consequently explore a potential positive neuroplasticity in relation to a better therapeutic outcome.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00667/fullDTIgray matterneuroplasticitypoly-drug useVBMwhite matter |
| spellingShingle | Human F. Unterrainer Human F. Unterrainer Human F. Unterrainer Michaela Hiebler-Ragger Michaela Hiebler-Ragger Karl Koschutnig Jürgen Fuchshuber Jürgen Fuchshuber Klemens Ragger Klemens Ragger Corinna M. Perchtold Ilona Papousek Elisabeth M. Weiss Andreas Fink Brain Structure Alterations in Poly-Drug Use: Reduced Cortical Thickness and White Matter Impairments in Regions Associated With Affective, Cognitive, and Motor Functions Frontiers in Psychiatry DTI gray matter neuroplasticity poly-drug use VBM white matter |
| title | Brain Structure Alterations in Poly-Drug Use: Reduced Cortical Thickness and White Matter Impairments in Regions Associated With Affective, Cognitive, and Motor Functions |
| title_full | Brain Structure Alterations in Poly-Drug Use: Reduced Cortical Thickness and White Matter Impairments in Regions Associated With Affective, Cognitive, and Motor Functions |
| title_fullStr | Brain Structure Alterations in Poly-Drug Use: Reduced Cortical Thickness and White Matter Impairments in Regions Associated With Affective, Cognitive, and Motor Functions |
| title_full_unstemmed | Brain Structure Alterations in Poly-Drug Use: Reduced Cortical Thickness and White Matter Impairments in Regions Associated With Affective, Cognitive, and Motor Functions |
| title_short | Brain Structure Alterations in Poly-Drug Use: Reduced Cortical Thickness and White Matter Impairments in Regions Associated With Affective, Cognitive, and Motor Functions |
| title_sort | brain structure alterations in poly drug use reduced cortical thickness and white matter impairments in regions associated with affective cognitive and motor functions |
| topic | DTI gray matter neuroplasticity poly-drug use VBM white matter |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00667/full |
| work_keys_str_mv | AT humanfunterrainer brainstructurealterationsinpolydrugusereducedcorticalthicknessandwhitematterimpairmentsinregionsassociatedwithaffectivecognitiveandmotorfunctions AT humanfunterrainer brainstructurealterationsinpolydrugusereducedcorticalthicknessandwhitematterimpairmentsinregionsassociatedwithaffectivecognitiveandmotorfunctions AT humanfunterrainer brainstructurealterationsinpolydrugusereducedcorticalthicknessandwhitematterimpairmentsinregionsassociatedwithaffectivecognitiveandmotorfunctions AT michaelahieblerragger brainstructurealterationsinpolydrugusereducedcorticalthicknessandwhitematterimpairmentsinregionsassociatedwithaffectivecognitiveandmotorfunctions AT michaelahieblerragger brainstructurealterationsinpolydrugusereducedcorticalthicknessandwhitematterimpairmentsinregionsassociatedwithaffectivecognitiveandmotorfunctions AT karlkoschutnig brainstructurealterationsinpolydrugusereducedcorticalthicknessandwhitematterimpairmentsinregionsassociatedwithaffectivecognitiveandmotorfunctions AT jurgenfuchshuber brainstructurealterationsinpolydrugusereducedcorticalthicknessandwhitematterimpairmentsinregionsassociatedwithaffectivecognitiveandmotorfunctions AT jurgenfuchshuber brainstructurealterationsinpolydrugusereducedcorticalthicknessandwhitematterimpairmentsinregionsassociatedwithaffectivecognitiveandmotorfunctions AT klemensragger brainstructurealterationsinpolydrugusereducedcorticalthicknessandwhitematterimpairmentsinregionsassociatedwithaffectivecognitiveandmotorfunctions AT klemensragger brainstructurealterationsinpolydrugusereducedcorticalthicknessandwhitematterimpairmentsinregionsassociatedwithaffectivecognitiveandmotorfunctions AT corinnamperchtold brainstructurealterationsinpolydrugusereducedcorticalthicknessandwhitematterimpairmentsinregionsassociatedwithaffectivecognitiveandmotorfunctions AT ilonapapousek brainstructurealterationsinpolydrugusereducedcorticalthicknessandwhitematterimpairmentsinregionsassociatedwithaffectivecognitiveandmotorfunctions AT elisabethmweiss brainstructurealterationsinpolydrugusereducedcorticalthicknessandwhitematterimpairmentsinregionsassociatedwithaffectivecognitiveandmotorfunctions AT andreasfink brainstructurealterationsinpolydrugusereducedcorticalthicknessandwhitematterimpairmentsinregionsassociatedwithaffectivecognitiveandmotorfunctions |