Association of the apolipoprotein E ε4 allele in a Serbian population with Alzheimer’s dementia
Although single nucleotide polymorphisms rs429358 and rs7412 in the apolipoprotein E gene (APOE) are widely investigated to analyze APOE alleles, there are no data on their association with Alzheimer’s disease (AD) dementia in a Serbian population. This study aimed to investigate the distribution of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Belgrade, University of Novi Sad
2023-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | https://doiserbia.nb.rs/img/doi/0354-4664/2023/0354-46642300026B.pdf |
| Summary: | Although single nucleotide polymorphisms rs429358 and rs7412 in the apolipoprotein E gene (APOE) are widely investigated to analyze APOE alleles, there are no data on their association with Alzheimer’s disease (AD) dementia in a Serbian population. This study aimed to investigate the distribution of APOE ε2/ε3/ε4 alleles in patients with dementia due to AD and cognitively unimpaired subjects and to assess the association of the APOE ε4 allele with disease risk in the Serbian population. A case-control study included patients with dementia due to AD and cognitively unimpaired individuals. APOE rs429358 and rs7412 were analyzed using the Real-Time PCR method with allele-specific TaqMan assays, followed by APOE ε2/ε3/ε4 allele carrier status analysis. Patients had a significantly higher frequency of the APOE ε4 allele than the control group (P<0.001). The APOE ε4 allele was found to be associated with a 3-fold higher risk of AD dementia compared to the reference ε3 allele (P<0.001). In conclusion, this is the first study to suggest that carriers of the APOE ε4 allele have a higher risk of developing dementia due to AD than those who carry the APOE ε3 allele in the Serbian population. |
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| ISSN: | 0354-4664 1821-4339 |