Early Regressive Development of the Subcommissural Organ of Two Human Fetuses with Non-Communicating Hydrocephalus
Hydrocephalus is a central nervous system condition characterized by CSF buildup and ventricular hypertrophy. It is divided into two types: communicative and non-communicating hydrocephalus. Congenital hydrocephalus has been linked to several changes in the subcommissural organ (SCO). However, it is...
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MDPI AG
2022-12-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/12/1966 |
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| author | Emilia M. Carmona-Calero Juan M. González-Toledo Luis G. Hernández-Abad Agustin Castañeyra-Perdomo Ibrahim González-Marrero |
| author_facet | Emilia M. Carmona-Calero Juan M. González-Toledo Luis G. Hernández-Abad Agustin Castañeyra-Perdomo Ibrahim González-Marrero |
| author_sort | Emilia M. Carmona-Calero |
| collection | DOAJ |
| description | Hydrocephalus is a central nervous system condition characterized by CSF buildup and ventricular hypertrophy. It is divided into two types: communicative and non-communicating hydrocephalus. Congenital hydrocephalus has been linked to several changes in the subcommissural organ (SCO). However, it is unclear whether these changes occur before or as a result of the hydrocephalic illness. This report presents three cases of human fetuses with hydrocephalus: one non-communicating case, two communicating cases, and two controls. Hematoxylin–Eosin (H&E) or cresyl violet and immunohistochemistry with anti-transthyretin were used to analyze SCO morphological and secretory changes. We conclude that in the cases presented here, there could be an early regression in the SCO of the communicating cases that is not present in the non-communicating case. |
| first_indexed | 2024-03-09T17:11:19Z |
| format | Article |
| id | doaj.art-4bb39cfc3ecf47a5baa747afa41a0f55 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T17:11:19Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-4bb39cfc3ecf47a5baa747afa41a0f552023-11-24T14:02:47ZengMDPI AGChildren2227-90672022-12-01912196610.3390/children9121966Early Regressive Development of the Subcommissural Organ of Two Human Fetuses with Non-Communicating HydrocephalusEmilia M. Carmona-Calero0Juan M. González-Toledo1Luis G. Hernández-Abad2Agustin Castañeyra-Perdomo3Ibrahim González-Marrero4Departamento de Ciencias Médicas Básicas, Facultad de Ciencias de la Salud, Campus de Ofra, Universidad de La Laguna, 38320 Santa Cruz de Tenerife, SpainDepartamento de Ciencias Médicas Básicas, Facultad de Ciencias de la Salud, Campus de Ofra, Universidad de La Laguna, 38320 Santa Cruz de Tenerife, SpainDepartamento de Ciencias Médicas Básicas, Facultad de Ciencias de la Salud, Campus de Ofra, Universidad de La Laguna, 38320 Santa Cruz de Tenerife, SpainDepartamento de Ciencias Médicas Básicas, Facultad de Ciencias de la Salud, Campus de Ofra, Universidad de La Laguna, 38320 Santa Cruz de Tenerife, SpainDepartamento de Ciencias Médicas Básicas, Facultad de Ciencias de la Salud, Campus de Ofra, Universidad de La Laguna, 38320 Santa Cruz de Tenerife, SpainHydrocephalus is a central nervous system condition characterized by CSF buildup and ventricular hypertrophy. It is divided into two types: communicative and non-communicating hydrocephalus. Congenital hydrocephalus has been linked to several changes in the subcommissural organ (SCO). However, it is unclear whether these changes occur before or as a result of the hydrocephalic illness. This report presents three cases of human fetuses with hydrocephalus: one non-communicating case, two communicating cases, and two controls. Hematoxylin–Eosin (H&E) or cresyl violet and immunohistochemistry with anti-transthyretin were used to analyze SCO morphological and secretory changes. We conclude that in the cases presented here, there could be an early regression in the SCO of the communicating cases that is not present in the non-communicating case.https://www.mdpi.com/2227-9067/9/12/1966human congenital hydrocephalussubcommissural organtransthyretin |
| spellingShingle | Emilia M. Carmona-Calero Juan M. González-Toledo Luis G. Hernández-Abad Agustin Castañeyra-Perdomo Ibrahim González-Marrero Early Regressive Development of the Subcommissural Organ of Two Human Fetuses with Non-Communicating Hydrocephalus Children human congenital hydrocephalus subcommissural organ transthyretin |
| title | Early Regressive Development of the Subcommissural Organ of Two Human Fetuses with Non-Communicating Hydrocephalus |
| title_full | Early Regressive Development of the Subcommissural Organ of Two Human Fetuses with Non-Communicating Hydrocephalus |
| title_fullStr | Early Regressive Development of the Subcommissural Organ of Two Human Fetuses with Non-Communicating Hydrocephalus |
| title_full_unstemmed | Early Regressive Development of the Subcommissural Organ of Two Human Fetuses with Non-Communicating Hydrocephalus |
| title_short | Early Regressive Development of the Subcommissural Organ of Two Human Fetuses with Non-Communicating Hydrocephalus |
| title_sort | early regressive development of the subcommissural organ of two human fetuses with non communicating hydrocephalus |
| topic | human congenital hydrocephalus subcommissural organ transthyretin |
| url | https://www.mdpi.com/2227-9067/9/12/1966 |
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