Single-Fluorescence ATP Sensor Based on Fluorescence Resonance Energy Transfer Reveals Role of Antibiotic-Induced ATP Perturbation in Mycobacterial Killing

Single-Fluorescence ATP Sensor Based on Fluorescence Resonance Energy Transfer Reveals Role of Antibiotic-Induced ATP Perturbation in Mycobacterial Killing

ABSTRACT The rapid emergence of multidrug-resistant/extensively drug-resistant tuberculosis (TB) is responsible for treatment failure in patients with TB and significantly endangers global public health. Recently, bioenergetics has become a new paradigm for anti-TB drug discovery and is based on the...

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Bibliographic Details
Main Authors: Lujie Liang, Daixi Lin, Yishen Chen, Jiachen Li, Wanfei Liang, Hui Zhao, Wenji Luo, Guo-bao Tian, Siyuan Feng
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mSystems
Subjects:
ATP
FRET
Mycobacterium
drug combination
Online Access:https://journals.asm.org/doi/10.1128/msystems.00209-22

Internet

https://journals.asm.org/doi/10.1128/msystems.00209-22

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