Developing an in-vivo physiological porcine model of inducing acute atraumatic compartment syndrome towards a non-invasive diagnosis using shear wave elastography
Abstract Compartment syndrome (CS) is a pathological event caused by elevated intracompartmental pressure (ICP); however, changes from the onset of inducing atraumatic CS remained unclear. The study aimed to investigate the physiological changes in a newly developed in vivo porcine acute atraumatic...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-01405-0 |
| _version_ | 1819003033962414080 |
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| author | Jong Woo Kang Jong Woong Park Tae Hyun Lim Keun Tae Kim Song Joo Lee |
| author_facet | Jong Woo Kang Jong Woong Park Tae Hyun Lim Keun Tae Kim Song Joo Lee |
| author_sort | Jong Woo Kang |
| collection | DOAJ |
| description | Abstract Compartment syndrome (CS) is a pathological event caused by elevated intracompartmental pressure (ICP); however, changes from the onset of inducing atraumatic CS remained unclear. The study aimed to investigate the physiological changes in a newly developed in vivo porcine acute atraumatic CS model. CS was induced by ischemia–reperfusion injury in the left hind leg of fourteen pigs divided into an echogenicity group (EG) and a shear wave elastography group (SEG). Echogenicity was measured in EG, and shear elastic modulus (SEM) was measured in SEG seven times before, at the onset of inducing CS, and every 30 min after the onset over eight hours. Simultaneously, ICP, blood pressure, and muscle perfusion pressure (MPP) were also measured in both groups. Our results indicate that SEM of the experimental leg in SEG significantly increased as CS developed compared to the control leg (p = 0.027), but no statistical difference in the echogenicity in EG was found between the experimental leg and control leg. There were also significant correlations between SEM and ICP (p < 0.001) and ICP and MPP (p < 0.001). Our method and findings can be a basis to develop a non-invasive diagnostic tool using a shear wave elastography for atraumatic CS. |
| first_indexed | 2024-12-20T23:14:34Z |
| format | Article |
| id | doaj.art-4bb647cdd420413db9a9deea6bb37411 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T23:14:34Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4bb647cdd420413db9a9deea6bb374112022-12-21T19:23:40ZengNature PortfolioScientific Reports2045-23222021-11-0111111210.1038/s41598-021-01405-0Developing an in-vivo physiological porcine model of inducing acute atraumatic compartment syndrome towards a non-invasive diagnosis using shear wave elastographyJong Woo Kang0Jong Woong Park1Tae Hyun Lim2Keun Tae Kim3Song Joo Lee4Department of Orthopaedic Surgery, Korea University Ansan HospitalDepartment of Orthopaedic Surgery, Korea University Anam HospitalCenter for Bionics, Biomedical Research Institute, Korea Institute of Science and TechnologyCenter for Bionics, Biomedical Research Institute, Korea Institute of Science and TechnologyCenter for Bionics, Biomedical Research Institute, Korea Institute of Science and TechnologyAbstract Compartment syndrome (CS) is a pathological event caused by elevated intracompartmental pressure (ICP); however, changes from the onset of inducing atraumatic CS remained unclear. The study aimed to investigate the physiological changes in a newly developed in vivo porcine acute atraumatic CS model. CS was induced by ischemia–reperfusion injury in the left hind leg of fourteen pigs divided into an echogenicity group (EG) and a shear wave elastography group (SEG). Echogenicity was measured in EG, and shear elastic modulus (SEM) was measured in SEG seven times before, at the onset of inducing CS, and every 30 min after the onset over eight hours. Simultaneously, ICP, blood pressure, and muscle perfusion pressure (MPP) were also measured in both groups. Our results indicate that SEM of the experimental leg in SEG significantly increased as CS developed compared to the control leg (p = 0.027), but no statistical difference in the echogenicity in EG was found between the experimental leg and control leg. There were also significant correlations between SEM and ICP (p < 0.001) and ICP and MPP (p < 0.001). Our method and findings can be a basis to develop a non-invasive diagnostic tool using a shear wave elastography for atraumatic CS.https://doi.org/10.1038/s41598-021-01405-0 |
| spellingShingle | Jong Woo Kang Jong Woong Park Tae Hyun Lim Keun Tae Kim Song Joo Lee Developing an in-vivo physiological porcine model of inducing acute atraumatic compartment syndrome towards a non-invasive diagnosis using shear wave elastography Scientific Reports |
| title | Developing an in-vivo physiological porcine model of inducing acute atraumatic compartment syndrome towards a non-invasive diagnosis using shear wave elastography |
| title_full | Developing an in-vivo physiological porcine model of inducing acute atraumatic compartment syndrome towards a non-invasive diagnosis using shear wave elastography |
| title_fullStr | Developing an in-vivo physiological porcine model of inducing acute atraumatic compartment syndrome towards a non-invasive diagnosis using shear wave elastography |
| title_full_unstemmed | Developing an in-vivo physiological porcine model of inducing acute atraumatic compartment syndrome towards a non-invasive diagnosis using shear wave elastography |
| title_short | Developing an in-vivo physiological porcine model of inducing acute atraumatic compartment syndrome towards a non-invasive diagnosis using shear wave elastography |
| title_sort | developing an in vivo physiological porcine model of inducing acute atraumatic compartment syndrome towards a non invasive diagnosis using shear wave elastography |
| url | https://doi.org/10.1038/s41598-021-01405-0 |
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