The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases
Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evide...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2017-09-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/3849.pdf |
| _version_ | 1797419838949294080 |
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| author | Marcin Gradowski Krzysztof Pawłowski |
| author_facet | Marcin Gradowski Krzysztof Pawłowski |
| author_sort | Marcin Gradowski |
| collection | DOAJ |
| description | Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine proteases. We also discuss how this finding can be reconciled with the apparently contradictory experimental results. |
| first_indexed | 2024-03-09T06:53:02Z |
| format | Article |
| id | doaj.art-4bb65cf7499a4e63953be6fecb2f4749 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:53:02Z |
| publishDate | 2017-09-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-4bb65cf7499a4e63953be6fecb2f47492023-12-03T10:15:18ZengPeerJ Inc.PeerJ2167-83592017-09-015e384910.7717/peerj.3849The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteasesMarcin Gradowski0Krzysztof Pawłowski1Department of Experimental Design and Bioinformatics, Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warszawa, PolandDepartment of Experimental Design and Bioinformatics, Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warszawa, PolandMany bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine proteases. We also discuss how this finding can be reconciled with the apparently contradictory experimental results.https://peerj.com/articles/3849.pdfStructure predictionBacterial effectorsProteasesMitochondrial carriers |
| spellingShingle | Marcin Gradowski Krzysztof Pawłowski The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases PeerJ Structure prediction Bacterial effectors Proteases Mitochondrial carriers |
| title | The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases |
| title_full | The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases |
| title_fullStr | The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases |
| title_full_unstemmed | The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases |
| title_short | The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases |
| title_sort | legionella pneumophila effector lpg1137 is a homologue of mitochondrial slc25 carrier proteins not of known serine proteases |
| topic | Structure prediction Bacterial effectors Proteases Mitochondrial carriers |
| url | https://peerj.com/articles/3849.pdf |
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