Recent advances in the application of Mendelian randomization to chronic kidney disease
AbstractObjective Chronic kidney disease (CKD) is a condition influenced by both genetic and environmental factors and has been a focus of extensive research. Utilizing Mendelian randomization, researchers have begun to untangle the complex causal relationships underlying CKD. This review delves int...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2319712 |
| _version_ | 1797246852693753856 |
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| author | Chaofan Wen Lanlan Chen Dan Jia Ziqi Liu Yidan Lin Guan Liu Shuo Zhang Baoshan Gao |
| author_facet | Chaofan Wen Lanlan Chen Dan Jia Ziqi Liu Yidan Lin Guan Liu Shuo Zhang Baoshan Gao |
| author_sort | Chaofan Wen |
| collection | DOAJ |
| description | AbstractObjective Chronic kidney disease (CKD) is a condition influenced by both genetic and environmental factors and has been a focus of extensive research. Utilizing Mendelian randomization, researchers have begun to untangle the complex causal relationships underlying CKD. This review delves into the advances and challenges in the application of MR in the field of nephrology, shifting from a mere summary of its principles and limitations to a more nuanced exploration of its contributions to our understanding of CKD.Methods Key findings from recent studies have been pivotal in reshaping our comprehension of CKD. Notably, evidence indicates that elevated testosterone levels may impair renal function, while higher sex hormone-binding globulin (SHBG) levels appear to be protective, predominantly in men. Surprisingly, variations in plasma glucose and glycated hemoglobin levels seem unaffected by genetically induced changes in the estimated glomerular filtration rate (eGFR), suggesting an independent pathway for renal function impairment.Results Furthermore, lifestyle factors such as physical activity and socioeconomic status emerge as significant influencers of CKD risk and kidney health. The relationship between sleep duration and CKD is nuanced; short sleep duration is linked to increased risk, while long sleep duration does not exhibit a clear causal effect. Additionally, lifestyle factors, including diet, exercise, and mental wellness activities, play a crucial role in kidney health. New insights also reveal a substantial causal connection between both central and general obesity and CKD onset, while no significant links were found between genetically modified LDL cholesterol or triglyceride levels and kidney function.Conclusion This review not only presents the recent achievements of MR in CKD research but also illuminates the path forwards, underscoring critical unanswered questions and proposing future research directions in this dynamic field. |
| first_indexed | 2024-03-07T16:17:44Z |
| format | Article |
| id | doaj.art-4bb757a3de6f443cafd217e5afdf3739 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-04-24T19:49:23Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-4bb757a3de6f443cafd217e5afdf37392024-03-25T02:13:35ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2319712Recent advances in the application of Mendelian randomization to chronic kidney diseaseChaofan Wen0Lanlan Chen1Dan Jia2Ziqi Liu3Yidan Lin4Guan Liu5Shuo Zhang6Baoshan Gao7Department of Urology and Surgery, the First Hospital of Jilin University, Changchun, Jilin Province, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, General Surgery Center, the First Hospital of Jilin University, Changchun, Jilin Province, ChinaDepartment of Urology and Surgery, the First Hospital of Jilin University, Changchun, Jilin Province, ChinaWeifang Medical University, Weifang, Shandong Province, ChinaHerberger Institute for Design and Arts, Arizona State University, Tempe, AZ, USADepartment of Pharmacology, Hebei Medical University, Shijiazhuang City, Hebei Province, ChinaDepartment of Pharmacology, Hebei Medical University, Shijiazhuang City, Hebei Province, ChinaDepartment of Urology and Surgery, the First Hospital of Jilin University, Changchun, Jilin Province, ChinaAbstractObjective Chronic kidney disease (CKD) is a condition influenced by both genetic and environmental factors and has been a focus of extensive research. Utilizing Mendelian randomization, researchers have begun to untangle the complex causal relationships underlying CKD. This review delves into the advances and challenges in the application of MR in the field of nephrology, shifting from a mere summary of its principles and limitations to a more nuanced exploration of its contributions to our understanding of CKD.Methods Key findings from recent studies have been pivotal in reshaping our comprehension of CKD. Notably, evidence indicates that elevated testosterone levels may impair renal function, while higher sex hormone-binding globulin (SHBG) levels appear to be protective, predominantly in men. Surprisingly, variations in plasma glucose and glycated hemoglobin levels seem unaffected by genetically induced changes in the estimated glomerular filtration rate (eGFR), suggesting an independent pathway for renal function impairment.Results Furthermore, lifestyle factors such as physical activity and socioeconomic status emerge as significant influencers of CKD risk and kidney health. The relationship between sleep duration and CKD is nuanced; short sleep duration is linked to increased risk, while long sleep duration does not exhibit a clear causal effect. Additionally, lifestyle factors, including diet, exercise, and mental wellness activities, play a crucial role in kidney health. New insights also reveal a substantial causal connection between both central and general obesity and CKD onset, while no significant links were found between genetically modified LDL cholesterol or triglyceride levels and kidney function.Conclusion This review not only presents the recent achievements of MR in CKD research but also illuminates the path forwards, underscoring critical unanswered questions and proposing future research directions in this dynamic field.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2319712Chronic kidney diseaseMendelian randomizationsystematic reviewmetabolic disordercardiovascular disease |
| spellingShingle | Chaofan Wen Lanlan Chen Dan Jia Ziqi Liu Yidan Lin Guan Liu Shuo Zhang Baoshan Gao Recent advances in the application of Mendelian randomization to chronic kidney disease Renal Failure Chronic kidney disease Mendelian randomization systematic review metabolic disorder cardiovascular disease |
| title | Recent advances in the application of Mendelian randomization to chronic kidney disease |
| title_full | Recent advances in the application of Mendelian randomization to chronic kidney disease |
| title_fullStr | Recent advances in the application of Mendelian randomization to chronic kidney disease |
| title_full_unstemmed | Recent advances in the application of Mendelian randomization to chronic kidney disease |
| title_short | Recent advances in the application of Mendelian randomization to chronic kidney disease |
| title_sort | recent advances in the application of mendelian randomization to chronic kidney disease |
| topic | Chronic kidney disease Mendelian randomization systematic review metabolic disorder cardiovascular disease |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2319712 |
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