The PINK1/PARK2/optineurin pathway of mitophagy is activated for protection in septic acute kidney injury

The PINK1/PARK2/optineurin pathway of mitophagy is activated for protection in septic acute kidney injury

Sepsis is the major cause of acute kidney injury (AKI) associated with high mortality rates. Mitochondrial dysfunction contributes to the pathophysiology of septic AKI. Mitophagy is an important mitochondrial quality control mechanism that selectively eliminates damaged mitochondria, but its role an...

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Bibliographic Details
Main Authors: Ying Wang, Jiefu Zhu, Zhiwen Liu, Shaoqun Shu, Ying Fu, Yuxue Liu, Juan Cai, Chengyuan Tang, Yu Liu, Xiaoming Yin, Zheng Dong
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Redox Biology
Subjects:
Acute kidney injury
Mitophgay
Optineurin
PINK1
PARK2
Sepsis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720309721

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