HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory

HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory

Mutations in the human HERC1 E3 ubiquitin ligase protein develop intellectual disability. The tambaleante (tbl) mouse carries a HERC1 mutation characterized by cerebellar ataxia due of adult cerebellar Purkinje cells death by extensive autophagy. Our previous studies demonstrated that both the neuro...

Full description

Bibliographic Details
Main Authors: Eva M. Pérez-Villegas, Mikel Pérez-Rodríguez, José V. Negrete-Díaz, Rocío Ruiz, Jose Luis Rosa, Guillermo Alvarez de Toledo, Antonio Rodríguez-Moreno, José A. Armengol
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Neuroanatomy
Subjects:
autophagy
dendritic spines
glutamatergic input
hippocampus
LTP
synapses
Online Access:https://www.frontiersin.org/articles/10.3389/fnana.2020.592797/full

Similar Items

Similar Items