Effect of a Point Mutation in mprF on Susceptibility to Daptomycin, Vancomycin, and Oxacillin in an MRSA Clinical Strain

Effect of a Point Mutation in mprF on Susceptibility to Daptomycin, Vancomycin, and Oxacillin in an MRSA Clinical Strain

We previously reported the sequential recovery of daptomycin-nonsusceptible MRSA clinical isolates with an L431F substitution in the MprF protein. The aim of the present study is to determine the effect of this mutation by replacing the mprF gene on the chromosome of a daptomycin-susceptible progeni...

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Bibliographic Details
Main Authors: Feng-Jui Chen, Tsai-Ling Lauderdale, Chen-Hsiang Lee, Yu-Chieh Hsu, I-Wen Huang, Pei-Chi Hsu, Chung-Shi Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Microbiology
Subjects:
MRSA
evolution
drug resistance
daptomycin
vancomycin
oxacillin
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01086/full

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