A Novel Magnetoelastic Immunosensor for Ultrasensitively Detecting Carcinoembryonic Antigen
Abstract A novel wireless immunosensor is developed for the ultra-sensitive detection of carcinoembryonic antigen. The optimum dimension of the microchips, as magnetoelastic sensitive units, was evaluated by simulation and experiments. The unique effects signal amplification and biocompatibility of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-08-01
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| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s11671-018-2632-0 |
| _version_ | 1827830676858077184 |
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| author | Yixia Zhang Xing Guo Lu Fan Qiang Zhang Shengbo Sang |
| author_facet | Yixia Zhang Xing Guo Lu Fan Qiang Zhang Shengbo Sang |
| author_sort | Yixia Zhang |
| collection | DOAJ |
| description | Abstract A novel wireless immunosensor is developed for the ultra-sensitive detection of carcinoembryonic antigen. The optimum dimension of the microchips, as magnetoelastic sensitive units, was evaluated by simulation and experiments. The unique effects signal amplification and biocompatibility of gold particles contribute to the stability and sensitivity of the sensor. Furthermore, to enhance sensitivity, the working concentrations of antibody and BSA are selected to be 50 mg/mL and 0.1%, respectively. Atom force microscope imaging sheds light on the biological analysis. The Nano-magnetoelastic immunosensor exhibits a linear response to the logarithm of carcinoembryonic antigen (CEA) concentrations ranging from 0.1 to 100 ng/mL, with a detection limit of 2.5 pg/mL. The designed biosensor has merits of excellent stability and sensitivity towards CEA. |
| first_indexed | 2024-03-12T04:32:44Z |
| format | Article |
| id | doaj.art-4bbf4880613e46d9865c7d219ef8df9f |
| institution | Directory Open Access Journal |
| issn | 1931-7573 1556-276X |
| language | English |
| last_indexed | 2024-03-12T04:32:44Z |
| publishDate | 2018-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-4bbf4880613e46d9865c7d219ef8df9f2023-09-03T10:00:22ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2018-08-011311610.1186/s11671-018-2632-0A Novel Magnetoelastic Immunosensor for Ultrasensitively Detecting Carcinoembryonic AntigenYixia Zhang0Xing Guo1Lu Fan2Qiang Zhang3Shengbo Sang4Institute of Applied Mechanics and Biomedical Engineering & National Demonstration Center for Experimental Mechanics Education, College of Mechanics, Taiyuan University of TechnologyMicro-Nano System Research Center & Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education, College of Information and Computer, Taiyuan University of TechnologyInstitute of Applied Mechanics and Biomedical Engineering & National Demonstration Center for Experimental Mechanics Education, College of Mechanics, Taiyuan University of TechnologyMicro-Nano System Research Center & Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education, College of Information and Computer, Taiyuan University of TechnologyMicro-Nano System Research Center & Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education, College of Information and Computer, Taiyuan University of TechnologyAbstract A novel wireless immunosensor is developed for the ultra-sensitive detection of carcinoembryonic antigen. The optimum dimension of the microchips, as magnetoelastic sensitive units, was evaluated by simulation and experiments. The unique effects signal amplification and biocompatibility of gold particles contribute to the stability and sensitivity of the sensor. Furthermore, to enhance sensitivity, the working concentrations of antibody and BSA are selected to be 50 mg/mL and 0.1%, respectively. Atom force microscope imaging sheds light on the biological analysis. The Nano-magnetoelastic immunosensor exhibits a linear response to the logarithm of carcinoembryonic antigen (CEA) concentrations ranging from 0.1 to 100 ng/mL, with a detection limit of 2.5 pg/mL. The designed biosensor has merits of excellent stability and sensitivity towards CEA.http://link.springer.com/article/10.1186/s11671-018-2632-0Magnetoelastic immunosensorGold nanoparticlesResonant frequencyAntibodyCEA |
| spellingShingle | Yixia Zhang Xing Guo Lu Fan Qiang Zhang Shengbo Sang A Novel Magnetoelastic Immunosensor for Ultrasensitively Detecting Carcinoembryonic Antigen Nanoscale Research Letters Magnetoelastic immunosensor Gold nanoparticles Resonant frequency Antibody CEA |
| title | A Novel Magnetoelastic Immunosensor for Ultrasensitively Detecting Carcinoembryonic Antigen |
| title_full | A Novel Magnetoelastic Immunosensor for Ultrasensitively Detecting Carcinoembryonic Antigen |
| title_fullStr | A Novel Magnetoelastic Immunosensor for Ultrasensitively Detecting Carcinoembryonic Antigen |
| title_full_unstemmed | A Novel Magnetoelastic Immunosensor for Ultrasensitively Detecting Carcinoembryonic Antigen |
| title_short | A Novel Magnetoelastic Immunosensor for Ultrasensitively Detecting Carcinoembryonic Antigen |
| title_sort | novel magnetoelastic immunosensor for ultrasensitively detecting carcinoembryonic antigen |
| topic | Magnetoelastic immunosensor Gold nanoparticles Resonant frequency Antibody CEA |
| url | http://link.springer.com/article/10.1186/s11671-018-2632-0 |
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