Therapeutic Strategies for Preventing Skeletal Muscle Fibrosis after Injury
Skeletal muscle repair after injury includes a complex and well-coordinated regenerative response. However, fibrosis often manifest, leading to aberrant regeneration and incomplete functional recovery. Research efforts have focused on the use of anti-fibrotic agents aimed at reducing the fibrotic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-04-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00087/full |
| _version_ | 1818514858560192512 |
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| author | Koyal eGarg Benjamin T. Corona Thomas J. Walters |
| author_facet | Koyal eGarg Benjamin T. Corona Thomas J. Walters |
| author_sort | Koyal eGarg |
| collection | DOAJ |
| description | Skeletal muscle repair after injury includes a complex and well-coordinated regenerative response. However, fibrosis often manifest, leading to aberrant regeneration and incomplete functional recovery. Research efforts have focused on the use of anti-fibrotic agents aimed at reducing the fibrotic response and improving functional recovery. While there are a number of mediators involved in the development of post-injury fibrosis, TGF-β1 is the primary pro-fibrogenic growth factor and the preponderance of research has focused on reducing its impact. The majority of these studies have shown that this strategy is effective in improving muscle healing following most common forms of muscle injuries. A number of these agents are FDA approved for other indications, clearing the way for rapid translation into clinical treatment. However all have potential side effects that must be considered in weighing the cost-benefit of the treatment require continued animal and clinical research. |
| first_indexed | 2024-12-11T00:21:28Z |
| format | Article |
| id | doaj.art-4bc0cf5dd40740b2a733c723017a0eda |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-11T00:21:28Z |
| publishDate | 2015-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-4bc0cf5dd40740b2a733c723017a0eda2022-12-22T01:27:44ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122015-04-01610.3389/fphar.2015.00087129173Therapeutic Strategies for Preventing Skeletal Muscle Fibrosis after InjuryKoyal eGarg0Benjamin T. Corona1Thomas J. Walters2United States Army Institute of Surgical ResearchUnited States Army Institute of Surgical ResearchUnited States Army Institute of Surgical ResearchSkeletal muscle repair after injury includes a complex and well-coordinated regenerative response. However, fibrosis often manifest, leading to aberrant regeneration and incomplete functional recovery. Research efforts have focused on the use of anti-fibrotic agents aimed at reducing the fibrotic response and improving functional recovery. While there are a number of mediators involved in the development of post-injury fibrosis, TGF-β1 is the primary pro-fibrogenic growth factor and the preponderance of research has focused on reducing its impact. The majority of these studies have shown that this strategy is effective in improving muscle healing following most common forms of muscle injuries. A number of these agents are FDA approved for other indications, clearing the way for rapid translation into clinical treatment. However all have potential side effects that must be considered in weighing the cost-benefit of the treatment require continued animal and clinical research.http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00087/fullExtracellular MatrixFibrosismuscle injurymuscle regenerationTGF-β1 |
| spellingShingle | Koyal eGarg Benjamin T. Corona Thomas J. Walters Therapeutic Strategies for Preventing Skeletal Muscle Fibrosis after Injury Frontiers in Pharmacology Extracellular Matrix Fibrosis muscle injury muscle regeneration TGF-β1 |
| title | Therapeutic Strategies for Preventing Skeletal Muscle Fibrosis after Injury |
| title_full | Therapeutic Strategies for Preventing Skeletal Muscle Fibrosis after Injury |
| title_fullStr | Therapeutic Strategies for Preventing Skeletal Muscle Fibrosis after Injury |
| title_full_unstemmed | Therapeutic Strategies for Preventing Skeletal Muscle Fibrosis after Injury |
| title_short | Therapeutic Strategies for Preventing Skeletal Muscle Fibrosis after Injury |
| title_sort | therapeutic strategies for preventing skeletal muscle fibrosis after injury |
| topic | Extracellular Matrix Fibrosis muscle injury muscle regeneration TGF-β1 |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00087/full |
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