Therapeutic Strategies for Preventing Skeletal Muscle Fibrosis after Injury

Therapeutic Strategies for Preventing Skeletal Muscle Fibrosis after Injury

Skeletal muscle repair after injury includes a complex and well-coordinated regenerative response. However, fibrosis often manifest, leading to aberrant regeneration and incomplete functional recovery. Research efforts have focused on the use of anti-fibrotic agents aimed at reducing the fibrotic...

Full description

Bibliographic Details
Main Authors:	Koyal eGarg, Benjamin T. Corona, Thomas J. Walters
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2015-04-01
Series:	Frontiers in Pharmacology
Subjects:	Extracellular Matrix Fibrosis muscle injury muscle regeneration TGF-β1
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00087/full

Similar Items

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis
by: Kelly L. Walton, et al.
Published: (2017-07-01)

A Novel Fibroblast Reporter Cell Line for in vitro Studies of Pulmonary Fibrosis
by: Julia Nemeth, et al.
Published: (2020-10-01)

Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition
by: Serge Ducommun, et al.
Published: (2024-04-01)

Extracellular matrix: the critical contributor to skeletal muscle regeneration—a comprehensive review
by: Khurshid Ahmad, et al.
Published: (2023-11-01)

The effect of radiation dose on mouse skeletal muscle remodeling
by: Hardee Justin P., et al.
Published: (2014-09-01)

Peptide mediated therapy in fibrosis: Mechanisms, advances and prospects
by: Xun Ye, et al.
Published: (2023-01-01)

Periostin Is Required for the Maintenance of Muscle Fibers during Muscle Regeneration
by: Naoki Ito, et al.
Published: (2021-03-01)

Therapeutic potential of topical administration of acriflavine against hypoxia-inducible factors for corneal fibrosis
by: Shuyan Zhu, et al.
Published: (2022-10-01)

Therapeutic Sources of Skeletal Muscle Regeneration from Volumetric Muscle Loss: A Narrative Review
by: Kwangjun Lee, et al.
Published: (2022-08-01)

Corrigendum: Therapeutic potential of topical administration of acriflavine against hypoxia-inducible factors for corneal fibrosis
by: Shuyan Zhu, et al.
Published: (2023-02-01)

Mesenchymal Stromal Cells and Their Secretome: New Therapeutic Perspectives for Skeletal Muscle Regeneration
by: Martina Sandonà, et al.
Published: (2021-05-01)

Indole-Based Small Molecules as Potential Therapeutic Agents for the Treatment of Fibrosis
by: Rui Qin, et al.
Published: (2022-02-01)

Aged Skeletal Muscle Retains the Ability to Remodel Extracellular Matrix for Degradation of Collagen Deposition after Muscle Injury
by: Wan-Jing Chen, et al.
Published: (2021-02-01)

P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis through AKT, ERK, and PKC
by: Mengjie Chen, et al.
Published: (2021-08-01)

Role of integrins in the development of fibrosis in the trabecular meshwork
by: Jennifer A. Faralli, et al.
Published: (2023-10-01)

GDF8 Contributes to Liver Fibrogenesis and Concomitant Skeletal Muscle Wasting
by: Alexander Culver, et al.
Published: (2023-07-01)

A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling
by: Asfia Soomro, et al.
Published: (2023-01-01)

Roles of nonmyogenic mesenchymal progenitors in pathogenesis and regeneration of skeletal muscle
by: Akiyoshi eUezumi, et al.
Published: (2014-02-01)

TGF-β Inhibitors for Therapeutic Management of Kidney Fibrosis
by: Cheol Ho Park, et al.
Published: (2022-11-01)

Effects of chemical and physical methods on decellularization of murine skeletal muscles
by: CARLA M.F.C. MIRANDA, et al.
Published: (2021-06-01)

Chronic alcohol ingestion delays skeletal muscle regeneration following injury
by: Dekeyser Graham J, et al.
Published: (2013-01-01)

Endothelial TGF-β signaling instructs smooth muscle cell development in the cardiac outflow tract
by: Giulia LM Boezio, et al.
Published: (2020-09-01)

tRNA‐derived small RNA, 5'tiRNA‐Gly‐CCC, promotes skeletal muscle regeneration through the inflammatory response
by: Linyuan Shen, et al.
Published: (2023-04-01)

Traditional Chinese Medicine for Topical Treatment of Skeletal Muscle Injury
by: Wing-Sum Siu, et al.
Published: (2023-08-01)

Impaired ECM Remodeling and Macrophage Activity Define Necrosis and Regeneration Following Damage in Aged Skeletal Muscle
by: Fasih Ahmad Rahman, et al.
Published: (2020-06-01)

Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics
by: Yuki Saito, et al.
Published: (2021-09-01)

Exploring the optimal impact force for chronic skeletal muscle injury induced by drop-mass technique in rats
by: Haiya Ge, et al.
Published: (2023-08-01)

Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies
by: Khurshid Ahmad, et al.
Published: (2020-02-01)

Asthmatic Eosinophils Alter the Gene Expression of Extracellular Matrix Proteins in Airway Smooth Muscle Cells and Pulmonary Fibroblasts
by: Ieva Janulaityte, et al.
Published: (2022-04-01)

Extracellular Matrix-Derived Hydrogels as Biomaterial for Different Skeletal Muscle Tissue Replacements
by: Daniele Boso, et al.
Published: (2020-05-01)

Signals from the Niche: Insights into the Role of IGF-1 and IL-6 in Modulating Skeletal Muscle Fibrosis
by: Laura Forcina, et al.
Published: (2019-03-01)

Molecular Mechanisms Responsible for the Rescue Effects of Pamidronate on Muscle Atrophy in Pediatric Burn Patients
by: Fabrizio Pin, et al.
Published: (2019-08-01)

BMSC Transplantation Aggravates Inflammation, Oxidative Stress, and Fibrosis and Impairs Skeletal Muscle Regeneration
by: Xiaoguang Liu, et al.
Published: (2019-02-01)

Methods for Accurate Assessment of Myofiber Maturity During Skeletal Muscle Regeneration
by: Yuki Yoshimoto, et al.
Published: (2020-04-01)

Low-Intensity Vibration Improves Muscle Healing in a Mouse Model of Laceration Injury
by: Thomas F. Corbiere, et al.
Published: (2017-12-01)

Beyond Borders of the Cell: How Extracellular Vesicles Shape COVID-19 for People with Cystic Fibrosis
by: Ewelina D. Hejenkowska, et al.
Published: (2024-03-01)

Smart ECM-Based Electrospun Biomaterials for Skeletal Muscle Regeneration
by: Sara Politi, et al.
Published: (2020-09-01)

Muscle injuries and strategies for improving their repair
by: Thomas Laumonier, et al.
Published: (2016-01-01)

Degradative Signaling in ATG7-Deficient Skeletal Muscle Following Cardiotoxin Injury
by: Fasih Ahmad Rahman, et al.
Published: (2023-09-01)

The Role of T Lymphocytes in Skeletal Muscle Repair From Traumatic and Contraction-Induced Injury
by: Michael R. Deyhle, et al.
Published: (2018-06-01)