Intervertebral Disc Tissue Engineering Using Additive Manufacturing
Intervertebral disc (IVD) degeneration is one of the major causes of lower back pain, a common health condition that greatly affects the quality of life. With an increasing elderly population and changes in lifestyle, there exists a high demand for novel treatment strategies for damaged IVDs. Resear...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/9/1/25 |
| _version_ | 1797442226535530496 |
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| author | Minami Yoshida Paul Richard Turner Jaydee Dones Cabral |
| author_facet | Minami Yoshida Paul Richard Turner Jaydee Dones Cabral |
| author_sort | Minami Yoshida |
| collection | DOAJ |
| description | Intervertebral disc (IVD) degeneration is one of the major causes of lower back pain, a common health condition that greatly affects the quality of life. With an increasing elderly population and changes in lifestyle, there exists a high demand for novel treatment strategies for damaged IVDs. Researchers have investigated IVD tissue engineering (TE) as a way to restore biological and mechanical functions by regenerating or replacing damaged discs using scaffolds with suitable cells. These scaffolds can be constructed using material extrusion additive manufacturing (AM), a technique used to build three-dimensional (3D), custom discs utilising computer-aided design (CAD). Structural geometry can be controlled via the manipulation of printing parameters, material selection, temperature, and various other processing parameters. To date, there are no clinically relevant TE-IVDs available. In this review, advances in AM-based approaches for IVD TE are briefly discussed in order to achieve a better understanding of the requirements needed to obtain more effective, and ultimately clinically relevant, IVD TE constructs. |
| first_indexed | 2024-03-09T12:38:45Z |
| format | Article |
| id | doaj.art-4bc1518208434876ae1510570453524a |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T12:38:45Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-4bc1518208434876ae1510570453524a2023-11-30T22:21:22ZengMDPI AGGels2310-28612022-12-01912510.3390/gels9010025Intervertebral Disc Tissue Engineering Using Additive ManufacturingMinami Yoshida0Paul Richard Turner1Jaydee Dones Cabral2Centre of Bioengineering & Nanomedicine, Department of Oral Rehabilitation, University of Otago, Dunedin 9054, New ZealandDepartment of Microbiology & Immunology, University of Otago, Dunedin 9054, New ZealandDepartment of Microbiology & Immunology, University of Otago, Dunedin 9054, New ZealandIntervertebral disc (IVD) degeneration is one of the major causes of lower back pain, a common health condition that greatly affects the quality of life. With an increasing elderly population and changes in lifestyle, there exists a high demand for novel treatment strategies for damaged IVDs. Researchers have investigated IVD tissue engineering (TE) as a way to restore biological and mechanical functions by regenerating or replacing damaged discs using scaffolds with suitable cells. These scaffolds can be constructed using material extrusion additive manufacturing (AM), a technique used to build three-dimensional (3D), custom discs utilising computer-aided design (CAD). Structural geometry can be controlled via the manipulation of printing parameters, material selection, temperature, and various other processing parameters. To date, there are no clinically relevant TE-IVDs available. In this review, advances in AM-based approaches for IVD TE are briefly discussed in order to achieve a better understanding of the requirements needed to obtain more effective, and ultimately clinically relevant, IVD TE constructs.https://www.mdpi.com/2310-2861/9/1/25intervertebral discadditive manufacturingtissue engineering3D printingbiomaterialshydrogels |
| spellingShingle | Minami Yoshida Paul Richard Turner Jaydee Dones Cabral Intervertebral Disc Tissue Engineering Using Additive Manufacturing Gels intervertebral disc additive manufacturing tissue engineering 3D printing biomaterials hydrogels |
| title | Intervertebral Disc Tissue Engineering Using Additive Manufacturing |
| title_full | Intervertebral Disc Tissue Engineering Using Additive Manufacturing |
| title_fullStr | Intervertebral Disc Tissue Engineering Using Additive Manufacturing |
| title_full_unstemmed | Intervertebral Disc Tissue Engineering Using Additive Manufacturing |
| title_short | Intervertebral Disc Tissue Engineering Using Additive Manufacturing |
| title_sort | intervertebral disc tissue engineering using additive manufacturing |
| topic | intervertebral disc additive manufacturing tissue engineering 3D printing biomaterials hydrogels |
| url | https://www.mdpi.com/2310-2861/9/1/25 |
| work_keys_str_mv | AT minamiyoshida intervertebraldisctissueengineeringusingadditivemanufacturing AT paulrichardturner intervertebraldisctissueengineeringusingadditivemanufacturing AT jaydeedonescabral intervertebraldisctissueengineeringusingadditivemanufacturing |