Regulation of macrophage function in inflammation and atherosclerosis
Atherosclerosis can be considered as both a chronic inflammatory disease and a lipid metabolism disorder. Innate immunity pathways have long been suspected to contribute to the initiation and progression of atherosclerosis. This suggests that crosstalk between lipid metabolism and innate immunity pa...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2009-01-01
|
| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520306258 |
| _version_ | 1818732504420450304 |
|---|---|
| author | Norihito Shibata Christopher K. Glass |
| author_facet | Norihito Shibata Christopher K. Glass |
| author_sort | Norihito Shibata |
| collection | DOAJ |
| description | Atherosclerosis can be considered as both a chronic inflammatory disease and a lipid metabolism disorder. Innate immunity pathways have long been suspected to contribute to the initiation and progression of atherosclerosis. This suggests that crosstalk between lipid metabolism and innate immunity pathways plays an important role for the development and/or the prevention of atherosclerosis. However, it is not fully defined how innate immunity affects lipid metabolism. Macrophages play a central role in atherogenesis through the accumulation of cholesterol and the production of inflammatory mediators and cytokines. Liver X receptors (LXRs) exert an important atheroprotective effect in the macrophage. In addition to regulating cholesterol metabolism, LXRs are also negative regulators of macrophage inflammatory gene responses. In this review, we will discuss the roles of LXRs in the macrophage as key factors that link innate immunity and lipid metabolism. |
| first_indexed | 2024-12-17T23:34:37Z |
| format | Article |
| id | doaj.art-4bc44965109b4521879e0950a25043ac |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T23:34:37Z |
| publishDate | 2009-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-4bc44965109b4521879e0950a25043ac2022-12-21T21:28:34ZengElsevierJournal of Lipid Research0022-22752009-01-0150S277S281Regulation of macrophage function in inflammation and atherosclerosisNorihito Shibata0Christopher K. Glass1Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651To whom correspondence should be addressed; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651Atherosclerosis can be considered as both a chronic inflammatory disease and a lipid metabolism disorder. Innate immunity pathways have long been suspected to contribute to the initiation and progression of atherosclerosis. This suggests that crosstalk between lipid metabolism and innate immunity pathways plays an important role for the development and/or the prevention of atherosclerosis. However, it is not fully defined how innate immunity affects lipid metabolism. Macrophages play a central role in atherogenesis through the accumulation of cholesterol and the production of inflammatory mediators and cytokines. Liver X receptors (LXRs) exert an important atheroprotective effect in the macrophage. In addition to regulating cholesterol metabolism, LXRs are also negative regulators of macrophage inflammatory gene responses. In this review, we will discuss the roles of LXRs in the macrophage as key factors that link innate immunity and lipid metabolism.http://www.sciencedirect.com/science/article/pii/S0022227520306258liver X receptorslipopolysaccharidelow density lipoprotein |
| spellingShingle | Norihito Shibata Christopher K. Glass Regulation of macrophage function in inflammation and atherosclerosis Journal of Lipid Research liver X receptors lipopolysaccharide low density lipoprotein |
| title | Regulation of macrophage function in inflammation and atherosclerosis |
| title_full | Regulation of macrophage function in inflammation and atherosclerosis |
| title_fullStr | Regulation of macrophage function in inflammation and atherosclerosis |
| title_full_unstemmed | Regulation of macrophage function in inflammation and atherosclerosis |
| title_short | Regulation of macrophage function in inflammation and atherosclerosis |
| title_sort | regulation of macrophage function in inflammation and atherosclerosis |
| topic | liver X receptors lipopolysaccharide low density lipoprotein |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520306258 |
| work_keys_str_mv | AT norihitoshibata regulationofmacrophagefunctionininflammationandatherosclerosis AT christopherkglass regulationofmacrophagefunctionininflammationandatherosclerosis |