Carbohydrate, Lipid, and Apolipoprotein Biomarkers in Blood and Risk of Thyroid Cancer: Findings from the AMORIS Cohort
Background: Previous studies have examined the link between blood metabolic biomarkers and risk of thyroid cancer, with inconclusive results. We performed a cohort study based on the Swedish Apolipoprotein-Related Mortality Risk (AMORIS) Cohort, including 561,388 individuals undergoing health examin...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/2/520 |
| _version_ | 1797444768338280448 |
|---|---|
| author | Xue Xiao Yi Huang Fetemeh Sadeghi Maria Feychting Niklas Hammar Fang Fang Zhe Zhang Qianwei Liu |
| author_facet | Xue Xiao Yi Huang Fetemeh Sadeghi Maria Feychting Niklas Hammar Fang Fang Zhe Zhang Qianwei Liu |
| author_sort | Xue Xiao |
| collection | DOAJ |
| description | Background: Previous studies have examined the link between blood metabolic biomarkers and risk of thyroid cancer, with inconclusive results. We performed a cohort study based on the Swedish Apolipoprotein-Related Mortality Risk (AMORIS) Cohort, including 561,388 individuals undergoing health examinations during 1985–1996 with a follow-up of >30 years. Methods: Newly diagnosed cases of thyroid cancer were identified from the Swedish Cancer Register. We assessed the associations of nine blood biomarkers of carbohydrate, lipid, and apolipoprotein metabolism measured at the time of health examinations with the subsequent risk of thyroid cancer and demonstrated the temporal trend of these biomarkers during the 30 years before diagnosis of thyroid cancer. Results: After multivariable adjustment, there was a lower risk of thyroid cancer, per standard deviation increase in total cholesterol (TC; HR 0.91; 95%CI 0.82–0.99) and HDL-C (HR 0.86; 95%CI 0.75–0.99). During the 20 to 30 years before diagnosis, patients with thyroid cancer, as a group, demonstrated constantly lower levels of TC and HDL-C, compared to controls. Further, patients with thyroid cancer demonstrated declining levels of these biomarkers during the ten years before diagnosis, whereas controls demonstrated stable or increasing levels. Conclusions: Taken together, we found blood levels of TC and HDL-C to be associated with the risk of thyroid cancer and that there was a declining level of metabolic biomarkers during the 10 years before diagnosis of thyroid cancer. |
| first_indexed | 2024-03-09T13:16:19Z |
| format | Article |
| id | doaj.art-4bc477ef3ded469cbf41c1605ec10e2a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T13:16:19Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4bc477ef3ded469cbf41c1605ec10e2a2023-11-30T21:35:02ZengMDPI AGCancers2072-66942023-01-0115252010.3390/cancers15020520Carbohydrate, Lipid, and Apolipoprotein Biomarkers in Blood and Risk of Thyroid Cancer: Findings from the AMORIS CohortXue Xiao0Yi Huang1Fetemeh Sadeghi2Maria Feychting3Niklas Hammar4Fang Fang5Zhe Zhang6Qianwei Liu7Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, ChinaDepartment of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, ChinaInstitute of Environmental Medicine, Karolinska Institutet, 17177 Stockholm, SwedenInstitute of Environmental Medicine, Karolinska Institutet, 17177 Stockholm, SwedenInstitute of Environmental Medicine, Karolinska Institutet, 17177 Stockholm, SwedenInstitute of Environmental Medicine, Karolinska Institutet, 17177 Stockholm, SwedenDepartment of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, ChinaInstitute of Environmental Medicine, Karolinska Institutet, 17177 Stockholm, SwedenBackground: Previous studies have examined the link between blood metabolic biomarkers and risk of thyroid cancer, with inconclusive results. We performed a cohort study based on the Swedish Apolipoprotein-Related Mortality Risk (AMORIS) Cohort, including 561,388 individuals undergoing health examinations during 1985–1996 with a follow-up of >30 years. Methods: Newly diagnosed cases of thyroid cancer were identified from the Swedish Cancer Register. We assessed the associations of nine blood biomarkers of carbohydrate, lipid, and apolipoprotein metabolism measured at the time of health examinations with the subsequent risk of thyroid cancer and demonstrated the temporal trend of these biomarkers during the 30 years before diagnosis of thyroid cancer. Results: After multivariable adjustment, there was a lower risk of thyroid cancer, per standard deviation increase in total cholesterol (TC; HR 0.91; 95%CI 0.82–0.99) and HDL-C (HR 0.86; 95%CI 0.75–0.99). During the 20 to 30 years before diagnosis, patients with thyroid cancer, as a group, demonstrated constantly lower levels of TC and HDL-C, compared to controls. Further, patients with thyroid cancer demonstrated declining levels of these biomarkers during the ten years before diagnosis, whereas controls demonstrated stable or increasing levels. Conclusions: Taken together, we found blood levels of TC and HDL-C to be associated with the risk of thyroid cancer and that there was a declining level of metabolic biomarkers during the 10 years before diagnosis of thyroid cancer.https://www.mdpi.com/2072-6694/15/2/520thyroid cancerglucoselipidriskcohort study |
| spellingShingle | Xue Xiao Yi Huang Fetemeh Sadeghi Maria Feychting Niklas Hammar Fang Fang Zhe Zhang Qianwei Liu Carbohydrate, Lipid, and Apolipoprotein Biomarkers in Blood and Risk of Thyroid Cancer: Findings from the AMORIS Cohort Cancers thyroid cancer glucose lipid risk cohort study |
| title | Carbohydrate, Lipid, and Apolipoprotein Biomarkers in Blood and Risk of Thyroid Cancer: Findings from the AMORIS Cohort |
| title_full | Carbohydrate, Lipid, and Apolipoprotein Biomarkers in Blood and Risk of Thyroid Cancer: Findings from the AMORIS Cohort |
| title_fullStr | Carbohydrate, Lipid, and Apolipoprotein Biomarkers in Blood and Risk of Thyroid Cancer: Findings from the AMORIS Cohort |
| title_full_unstemmed | Carbohydrate, Lipid, and Apolipoprotein Biomarkers in Blood and Risk of Thyroid Cancer: Findings from the AMORIS Cohort |
| title_short | Carbohydrate, Lipid, and Apolipoprotein Biomarkers in Blood and Risk of Thyroid Cancer: Findings from the AMORIS Cohort |
| title_sort | carbohydrate lipid and apolipoprotein biomarkers in blood and risk of thyroid cancer findings from the amoris cohort |
| topic | thyroid cancer glucose lipid risk cohort study |
| url | https://www.mdpi.com/2072-6694/15/2/520 |
| work_keys_str_mv | AT xuexiao carbohydratelipidandapolipoproteinbiomarkersinbloodandriskofthyroidcancerfindingsfromtheamoriscohort AT yihuang carbohydratelipidandapolipoproteinbiomarkersinbloodandriskofthyroidcancerfindingsfromtheamoriscohort AT fetemehsadeghi carbohydratelipidandapolipoproteinbiomarkersinbloodandriskofthyroidcancerfindingsfromtheamoriscohort AT mariafeychting carbohydratelipidandapolipoproteinbiomarkersinbloodandriskofthyroidcancerfindingsfromtheamoriscohort AT niklashammar carbohydratelipidandapolipoproteinbiomarkersinbloodandriskofthyroidcancerfindingsfromtheamoriscohort AT fangfang carbohydratelipidandapolipoproteinbiomarkersinbloodandriskofthyroidcancerfindingsfromtheamoriscohort AT zhezhang carbohydratelipidandapolipoproteinbiomarkersinbloodandriskofthyroidcancerfindingsfromtheamoriscohort AT qianweiliu carbohydratelipidandapolipoproteinbiomarkersinbloodandriskofthyroidcancerfindingsfromtheamoriscohort |