Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture
Bei-Bei Huo,1,* Mou-Xiong Zheng,2,* Xu-Yun Hua,2,* Jun Shen,3 Jia-Jia Wu,4 Jian-Guang Xu1 1School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Department of Traumatology and Orthopedics, Yueyang Hospital, Shanghai Un...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-03-01
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| Series: | Journal of Pain Research |
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| Online Access: | https://www.dovepress.com/brain-metabolism-in-rats-with-neuropathic-pain-induced-by-brachial-ple-peer-reviewed-article-JPR |
| _version_ | 1818576180009238528 |
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| author | Huo BB Zheng MX Hua XY Shen J Wu JJ Xu JG |
| author_facet | Huo BB Zheng MX Hua XY Shen J Wu JJ Xu JG |
| author_sort | Huo BB |
| collection | DOAJ |
| description | Bei-Bei Huo,1,* Mou-Xiong Zheng,2,* Xu-Yun Hua,2,* Jun Shen,3 Jia-Jia Wu,4 Jian-Guang Xu1 1School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Department of Traumatology and Orthopedics, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 3Department of Orthopedic, Guanghua Hospital of Integrative Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 4Department of Rehabilitation Medicine, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian-Guang XuSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, People’s Republic of ChinaTel +86 21-51322091Fax +86 21-51322042Email xjg@shutcm.edu.cnPurpose: Brain organisation is involved in the mechanism of neuropathic pain. Acupuncture is a common clinical practise in traditional Chinese medicine for the treatment of chronic pain. This study explored electroacupuncture’s effects on brain metabolism following brachial plexus avulsion injury (BPAI)-induced pain.Methods: A total of 32 female rats were randomised into a normal group, model group, sham electroacupuncture group, and electroacupuncture group. A pain model was included via right BPAI. The electroacupuncture intervention at cervical “Jiaji” points (C5-7) was performed for 11 weeks. The mechanical withdrawal threshold of the non-injured (left) forepaw was measured at the baseline and on days 3, 7, 14, 21, 28, 56, 84, and 112 subsequent to BPAI. Positron emission tomography (PET) was applied to explore metabolic changes on days 28, 84, and 112.Results: After electroacupuncture, the mechanical withdrawal threshold of the left forepaws was significantly elevated and the effect persisted until 4 weeks after the intervention ceased (p< 0.05 or p< 0.001). In the sensorimotor-related brain regions, standardised uptake values in the bilateral somatosensory and motor cortices were observed in the electroacupuncture group. Metabolism particularly increased in the right somatosensory cortex. Metabolism changes also occurred in the pain-related brain regions and emotion- and cognition-related brain regions.Conclusion: The present study demonstrated the beneficial effects of electroacupuncture for relieving BPAI-induced neuropathic pain in rats. Electroacupuncture intervention might inhibit maladaptive plasticity in brain areas governing multidimensional functions, especially in sensorimotor- and cognition-related cortices.Keywords: brachial plexus avulsion injury, neuropathic pain, metabolic mechanism, small animal 18F-FDG PET/CT, electroacupuncture
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| first_indexed | 2024-12-16T06:09:55Z |
| format | Article |
| id | doaj.art-4bc6d420ad60494f914ed4a76aa868ae |
| institution | Directory Open Access Journal |
| issn | 1178-7090 |
| language | English |
| last_indexed | 2024-12-16T06:09:55Z |
| publishDate | 2020-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj.art-4bc6d420ad60494f914ed4a76aa868ae2022-12-21T22:41:25ZengDove Medical PressJournal of Pain Research1178-70902020-03-01Volume 1358559552654Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via ElectroacupunctureHuo BBZheng MXHua XYShen JWu JJXu JGBei-Bei Huo,1,* Mou-Xiong Zheng,2,* Xu-Yun Hua,2,* Jun Shen,3 Jia-Jia Wu,4 Jian-Guang Xu1 1School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Department of Traumatology and Orthopedics, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 3Department of Orthopedic, Guanghua Hospital of Integrative Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 4Department of Rehabilitation Medicine, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian-Guang XuSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, People’s Republic of ChinaTel +86 21-51322091Fax +86 21-51322042Email xjg@shutcm.edu.cnPurpose: Brain organisation is involved in the mechanism of neuropathic pain. Acupuncture is a common clinical practise in traditional Chinese medicine for the treatment of chronic pain. This study explored electroacupuncture’s effects on brain metabolism following brachial plexus avulsion injury (BPAI)-induced pain.Methods: A total of 32 female rats were randomised into a normal group, model group, sham electroacupuncture group, and electroacupuncture group. A pain model was included via right BPAI. The electroacupuncture intervention at cervical “Jiaji” points (C5-7) was performed for 11 weeks. The mechanical withdrawal threshold of the non-injured (left) forepaw was measured at the baseline and on days 3, 7, 14, 21, 28, 56, 84, and 112 subsequent to BPAI. Positron emission tomography (PET) was applied to explore metabolic changes on days 28, 84, and 112.Results: After electroacupuncture, the mechanical withdrawal threshold of the left forepaws was significantly elevated and the effect persisted until 4 weeks after the intervention ceased (p< 0.05 or p< 0.001). In the sensorimotor-related brain regions, standardised uptake values in the bilateral somatosensory and motor cortices were observed in the electroacupuncture group. Metabolism particularly increased in the right somatosensory cortex. Metabolism changes also occurred in the pain-related brain regions and emotion- and cognition-related brain regions.Conclusion: The present study demonstrated the beneficial effects of electroacupuncture for relieving BPAI-induced neuropathic pain in rats. Electroacupuncture intervention might inhibit maladaptive plasticity in brain areas governing multidimensional functions, especially in sensorimotor- and cognition-related cortices.Keywords: brachial plexus avulsion injury, neuropathic pain, metabolic mechanism, small animal 18F-FDG PET/CT, electroacupuncture https://www.dovepress.com/brain-metabolism-in-rats-with-neuropathic-pain-induced-by-brachial-ple-peer-reviewed-article-JPRbrachial plexus avulsion injuryneuropathic painmetabolic mechanismsmall animal 18f-fdg pet/ctelectroacupuncture |
| spellingShingle | Huo BB Zheng MX Hua XY Shen J Wu JJ Xu JG Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture Journal of Pain Research brachial plexus avulsion injury neuropathic pain metabolic mechanism small animal 18f-fdg pet/ct electroacupuncture |
| title | Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture |
| title_full | Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture |
| title_fullStr | Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture |
| title_full_unstemmed | Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture |
| title_short | Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture |
| title_sort | brain metabolism in rats with neuropathic pain induced by brachial plexus avulsion injury and treated via electroacupuncture |
| topic | brachial plexus avulsion injury neuropathic pain metabolic mechanism small animal 18f-fdg pet/ct electroacupuncture |
| url | https://www.dovepress.com/brain-metabolism-in-rats-with-neuropathic-pain-induced-by-brachial-ple-peer-reviewed-article-JPR |
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