53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis

53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis

Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or senescence is often triggered after mitotic exit. To characterize this process, we conducted CRISPR-mediated loss-of-function screens using a cell-based assay in which mitosis is consistently disturbed by ce...

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Bibliographic Details
Main Authors: Chii Shyang Fong, Gregory Mazo, Tuhin Das, Joshua Goodman, Minhee Kim, Brian P O'Rourke, Denisse Izquierdo, Meng-Fu Bryan Tsou
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
mitosis
stress signalling
cell cycle arrest
Online Access:https://elifesciences.org/articles/16270

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