Aspartate decarboxylase (PanD) as a new target of pyrazinamide in Mycobacterium tuberculosis

Aspartate decarboxylase (PanD) as a new target of pyrazinamide in Mycobacterium tuberculosis

Pyrazinamide (PZA) is a frontline anti-tuberculosis drug that plays a crucial role in the treatment of both drug-susceptible and multidrug-resistant tuberculosis (MDR-TB). PZA is a prodrug that is converted to its active form, pyrazinoic acid (POA), by a nicotinamidase/pyrazinamidase encoded by the...

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Bibliographic Details
Main Authors: Wanliang Shi, Jiazhen Chen, Jie Feng, Peng Cui, Shuo Zhang, Xinhua Weng, Wenhong Zhang, Ying Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2014-01-01
Series:Emerging Microbes and Infections
Subjects:
Pyrazinamide
pyrazinoic acid resistance
mode of action
panD
aspartate decarboxylase
Online Access:https://www.tandfonline.com/doi/10.1038/emi.2014.61

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