Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview
The incidence of inflammatory bowel disease (IBD) and the associated risk of colon cancer are increasing globally. Traditional Chinese medicine (TCM) treatment has unique advantages. The Sishen Pill, a common Chinese patented drug used to treat abdominal pain and diarrhea, consists mainly of Psorale...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-04-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1375585/full |
| _version_ | 1827291129706446848 |
|---|---|
| author | Boxun Zhang Yingying Cheng Qin Jian Sirui Xiang Qi Xu Chuchu Wang Chuan Yang Junzhi Lin Chuan Zheng Chuan Zheng |
| author_facet | Boxun Zhang Yingying Cheng Qin Jian Sirui Xiang Qi Xu Chuchu Wang Chuan Yang Junzhi Lin Chuan Zheng Chuan Zheng |
| author_sort | Boxun Zhang |
| collection | DOAJ |
| description | The incidence of inflammatory bowel disease (IBD) and the associated risk of colon cancer are increasing globally. Traditional Chinese medicine (TCM) treatment has unique advantages. The Sishen Pill, a common Chinese patented drug used to treat abdominal pain and diarrhea, consists mainly of Psoraleae Fructus, Myristicae Semen, Euodiae Fructus, and Schisandra Chinensis. Modern research has confirmed that Sishen Pill and its active secondary metabolites, such as psoralen, myristicin, evodiamine, and schisandrin, can improve intestinal inflammation and exert antitumor pharmacological effects. Common mechanisms in treating IBD and colon cancer mainly include regulating inflammation-related signaling pathways such as nuclear factor-kappa B, mitogen-activated protein kinase, phosphatidylinositol 3-kinase, NOD-like receptor heat protein domain-related protein 3, and wingless-type MMTV integration site family; NF-E2-related factor 2 and hypoxia-inducible factor 1α to inhibit oxidative stress; mitochondrial autophagy and endoplasmic reticulum stress; intestinal immune cell differentiation and function through the Janus kinase/signal transducer and activator of transcription pathway; and improving the gut microbiota and intestinal barrier. Overall, existing evidence suggests the potential of the Sishen pill to improve IBD and suppress inflammation-to-cancer transformation. However, large-scale randomized controlled clinical studies and research on the safety of these clinical applications are urgently required. |
| first_indexed | 2024-04-24T12:30:33Z |
| format | Article |
| id | doaj.art-4bca1a5b1b2c496bbfea2aa09b0be669 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-24T12:30:33Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-4bca1a5b1b2c496bbfea2aa09b0be6692024-04-08T04:32:45ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-04-011510.3389/fphar.2024.13755851375585Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overviewBoxun Zhang0Yingying Cheng1Qin Jian2Sirui Xiang3Qi Xu4Chuchu Wang5Chuan Yang6Junzhi Lin7Chuan Zheng8Chuan Zheng9Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCollege of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCollege of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCollege of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSichuan Provincial Engineering Research Center of Innovative Re-development of Famous Classical Formulas, Tianfu TCM Innovation Harbour, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaThe incidence of inflammatory bowel disease (IBD) and the associated risk of colon cancer are increasing globally. Traditional Chinese medicine (TCM) treatment has unique advantages. The Sishen Pill, a common Chinese patented drug used to treat abdominal pain and diarrhea, consists mainly of Psoraleae Fructus, Myristicae Semen, Euodiae Fructus, and Schisandra Chinensis. Modern research has confirmed that Sishen Pill and its active secondary metabolites, such as psoralen, myristicin, evodiamine, and schisandrin, can improve intestinal inflammation and exert antitumor pharmacological effects. Common mechanisms in treating IBD and colon cancer mainly include regulating inflammation-related signaling pathways such as nuclear factor-kappa B, mitogen-activated protein kinase, phosphatidylinositol 3-kinase, NOD-like receptor heat protein domain-related protein 3, and wingless-type MMTV integration site family; NF-E2-related factor 2 and hypoxia-inducible factor 1α to inhibit oxidative stress; mitochondrial autophagy and endoplasmic reticulum stress; intestinal immune cell differentiation and function through the Janus kinase/signal transducer and activator of transcription pathway; and improving the gut microbiota and intestinal barrier. Overall, existing evidence suggests the potential of the Sishen pill to improve IBD and suppress inflammation-to-cancer transformation. However, large-scale randomized controlled clinical studies and research on the safety of these clinical applications are urgently required.https://www.frontiersin.org/articles/10.3389/fphar.2024.1375585/fullinflammatory bowel diseasecolon cancerSishen Pillmolecular mechanismnatural product |
| spellingShingle | Boxun Zhang Yingying Cheng Qin Jian Sirui Xiang Qi Xu Chuchu Wang Chuan Yang Junzhi Lin Chuan Zheng Chuan Zheng Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview Frontiers in Pharmacology inflammatory bowel disease colon cancer Sishen Pill molecular mechanism natural product |
| title | Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview |
| title_full | Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview |
| title_fullStr | Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview |
| title_full_unstemmed | Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview |
| title_short | Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview |
| title_sort | sishen pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer an overview |
| topic | inflammatory bowel disease colon cancer Sishen Pill molecular mechanism natural product |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1375585/full |
| work_keys_str_mv | AT boxunzhang sishenpillanditsactivephytochemicalsintreatinginflammatoryboweldiseaseandcoloncanceranoverview AT yingyingcheng sishenpillanditsactivephytochemicalsintreatinginflammatoryboweldiseaseandcoloncanceranoverview AT qinjian sishenpillanditsactivephytochemicalsintreatinginflammatoryboweldiseaseandcoloncanceranoverview AT siruixiang sishenpillanditsactivephytochemicalsintreatinginflammatoryboweldiseaseandcoloncanceranoverview AT qixu sishenpillanditsactivephytochemicalsintreatinginflammatoryboweldiseaseandcoloncanceranoverview AT chuchuwang sishenpillanditsactivephytochemicalsintreatinginflammatoryboweldiseaseandcoloncanceranoverview AT chuanyang sishenpillanditsactivephytochemicalsintreatinginflammatoryboweldiseaseandcoloncanceranoverview AT junzhilin sishenpillanditsactivephytochemicalsintreatinginflammatoryboweldiseaseandcoloncanceranoverview AT chuanzheng sishenpillanditsactivephytochemicalsintreatinginflammatoryboweldiseaseandcoloncanceranoverview AT chuanzheng sishenpillanditsactivephytochemicalsintreatinginflammatoryboweldiseaseandcoloncanceranoverview |