LONG-LASTING CONTROL OF HER-2 POSITIVE DISSEMINATED BREAST CANCER IN A REPRODUCTIVE AGED PATIENT
Background. Breast cancer ranks as the second most common cancer (14.9 %) and the most common female cancer (20.9 %) in Russia. at the time of diagnosis, 11.0 % of patients have already developed metastases, and 10.3 % of patients die within the first year of diagnosis from disease progression. dist...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2021-06-01
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| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/1825 |
| _version_ | 1797875786626105344 |
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| author | A. V. Vazhenin N. V. Voroshina O. S. Tereshin N. S. Dubrovskaya |
| author_facet | A. V. Vazhenin N. V. Voroshina O. S. Tereshin N. S. Dubrovskaya |
| author_sort | A. V. Vazhenin |
| collection | DOAJ |
| description | Background. Breast cancer ranks as the second most common cancer (14.9 %) and the most common female cancer (20.9 %) in Russia. at the time of diagnosis, 11.0 % of patients have already developed metastases, and 10.3 % of patients die within the first year of diagnosis from disease progression. distant metastasis is the leading cause of death from breast cancer, and brain metastasis is a significant prognostic factor for poor survival.Case description. We report the case of a long-lasting control of advanced breast cancer with brain metastases in a 32-year-old woman. low grade tubular breast carcinoma was histologically confirmed. immunohistochemical study: eR-ts-4 points, PR-ts – 3 points, Her-2 positive, Ki67 – 35.0 %. BRCa1 5382ins C mutation was not detected. the long-term use of therapy with lapatinib and capecitabine was described.Conclusion. this case demonstrates the feasibility of long-term (31 months) control over Her-2 positive disseminated breast cancer with multiple metastases to the brain and bones, while maintaining the quality of life and social activity of a young patient. despite the risks associated with whole brain radiotherapy, no cognitive impairment was observed. therapy with lapatinib and capecitabine was effective for 28 months with good tolerance. |
| first_indexed | 2024-04-10T01:52:03Z |
| format | Article |
| id | doaj.art-4bca8c426d804812881dea6a8c99f216 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:52:03Z |
| publishDate | 2021-06-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-4bca8c426d804812881dea6a8c99f2162023-03-13T09:05:54ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682021-06-0120315816410.21294/1814-4861-2021-20-3-158-164875LONG-LASTING CONTROL OF HER-2 POSITIVE DISSEMINATED BREAST CANCER IN A REPRODUCTIVE AGED PATIENTA. V. Vazhenin0N. V. Voroshina1O. S. Tereshin2N. S. Dubrovskaya3ГБУЗ «Челябинский областной клинический центр онкологии и ядерной медицины»; ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава РоссииГБУЗ «Челябинский областной клинический центр онкологии и ядерной медицины»ГБУЗ «Челябинский областной клинический центр онкологии и ядерной медицины»ГБУЗ «Челябинский областной клинический центр онкологии и ядерной медицины»Background. Breast cancer ranks as the second most common cancer (14.9 %) and the most common female cancer (20.9 %) in Russia. at the time of diagnosis, 11.0 % of patients have already developed metastases, and 10.3 % of patients die within the first year of diagnosis from disease progression. distant metastasis is the leading cause of death from breast cancer, and brain metastasis is a significant prognostic factor for poor survival.Case description. We report the case of a long-lasting control of advanced breast cancer with brain metastases in a 32-year-old woman. low grade tubular breast carcinoma was histologically confirmed. immunohistochemical study: eR-ts-4 points, PR-ts – 3 points, Her-2 positive, Ki67 – 35.0 %. BRCa1 5382ins C mutation was not detected. the long-term use of therapy with lapatinib and capecitabine was described.Conclusion. this case demonstrates the feasibility of long-term (31 months) control over Her-2 positive disseminated breast cancer with multiple metastases to the brain and bones, while maintaining the quality of life and social activity of a young patient. despite the risks associated with whole brain radiotherapy, no cognitive impairment was observed. therapy with lapatinib and capecitabine was effective for 28 months with good tolerance.https://www.siboncoj.ru/jour/article/view/1825диссеминированный рак молочной железыгиперэкспрессия her-2 neuметастатическое поражение головного мозгалучевая терапия на головной мозгтаргетная терапиякачество жизни |
| spellingShingle | A. V. Vazhenin N. V. Voroshina O. S. Tereshin N. S. Dubrovskaya LONG-LASTING CONTROL OF HER-2 POSITIVE DISSEMINATED BREAST CANCER IN A REPRODUCTIVE AGED PATIENT Сибирский онкологический журнал диссеминированный рак молочной железы гиперэкспрессия her-2 neu метастатическое поражение головного мозга лучевая терапия на головной мозг таргетная терапия качество жизни |
| title | LONG-LASTING CONTROL OF HER-2 POSITIVE DISSEMINATED BREAST CANCER IN A REPRODUCTIVE AGED PATIENT |
| title_full | LONG-LASTING CONTROL OF HER-2 POSITIVE DISSEMINATED BREAST CANCER IN A REPRODUCTIVE AGED PATIENT |
| title_fullStr | LONG-LASTING CONTROL OF HER-2 POSITIVE DISSEMINATED BREAST CANCER IN A REPRODUCTIVE AGED PATIENT |
| title_full_unstemmed | LONG-LASTING CONTROL OF HER-2 POSITIVE DISSEMINATED BREAST CANCER IN A REPRODUCTIVE AGED PATIENT |
| title_short | LONG-LASTING CONTROL OF HER-2 POSITIVE DISSEMINATED BREAST CANCER IN A REPRODUCTIVE AGED PATIENT |
| title_sort | long lasting control of her 2 positive disseminated breast cancer in a reproductive aged patient |
| topic | диссеминированный рак молочной железы гиперэкспрессия her-2 neu метастатическое поражение головного мозга лучевая терапия на головной мозг таргетная терапия качество жизни |
| url | https://www.siboncoj.ru/jour/article/view/1825 |
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