Targeting of the Pilosebaceous Follicle by Liquid Crystal Nanocarriers: In Vitro and In Vivo Effects of the Entrapped Minoxidil
The topical administration of active compounds represents an advantageous strategy to reach the various skin components as well as its appendages. Pilosebaceous follicles are skin appendages originating in the deeper skin layers. They are very difficult to target, and hence higher active dosages are...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/11/1127 |
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| author | Massimo Fresta Antonia Mancuso Maria Chiara Cristiano Konrad Urbanek Felisa Cilurzo Donato Cosco Michelangelo Iannone Donatella Paolino |
| author_facet | Massimo Fresta Antonia Mancuso Maria Chiara Cristiano Konrad Urbanek Felisa Cilurzo Donato Cosco Michelangelo Iannone Donatella Paolino |
| author_sort | Massimo Fresta |
| collection | DOAJ |
| description | The topical administration of active compounds represents an advantageous strategy to reach the various skin components as well as its appendages. Pilosebaceous follicles are skin appendages originating in the deeper skin layers. They are very difficult to target, and hence higher active dosages are generally required to achieve effective biological responses, thus favoring the rise of side effects. The aim of this work was to design a supramolecular colloidal carrier, i.e., a liquid crystal nanocarrier, for the selective delivery of active compounds into the pilosebaceous follicle. This nanocarrier showed mean sizes of ~80 nm, a good stability, a negative surface charge, and great safety properties. In vitro studies highlighted its ability to contain and release different substances and to successfully permeate the skin. Minoxidil was encapsulated in the nanocarriers and the in vivo biological effect was compared with a conventional dosage form. Minoxidil-loaded liquid crystal nanocarrier was able to selectively reach the pilosebaceous follicle, thus allowing an increased biological effectiveness of the delivered active in terms of biological response, duration of the biological effects, and reduction of collaterals. Our investigation showed that liquid crystal nanocarriers represent a promising device for the treatment of different pilosebaceous follicular impairments/diseases. |
| first_indexed | 2024-03-10T14:39:50Z |
| format | Article |
| id | doaj.art-4bcb6f4c0e3a4738930d227394f6f32b |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T14:39:50Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-4bcb6f4c0e3a4738930d227394f6f32b2023-11-20T21:53:58ZengMDPI AGPharmaceutics1999-49232020-11-011211112710.3390/pharmaceutics12111127Targeting of the Pilosebaceous Follicle by Liquid Crystal Nanocarriers: In Vitro and In Vivo Effects of the Entrapped MinoxidilMassimo Fresta0Antonia Mancuso1Maria Chiara Cristiano2Konrad Urbanek3Felisa Cilurzo4Donato Cosco5Michelangelo Iannone6Donatella Paolino7Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario “S. Venuta”, viale Europa, 88100 Germaneto (CZ), ItalyDepartment of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario “S. Venuta”, viale Europa, 88100 Germaneto (CZ), ItalyDepartment of Experimental and Clinical Medicine, University “Magna Græcia” of Catanzaro, Campus Universitario “S. Venuta”, viale Europa, 88100 Germaneto (CZ), ItalyDepartment of Experimental and Clinical Medicine, University “Magna Græcia” of Catanzaro, Campus Universitario “S. Venuta”, viale Europa, 88100 Germaneto (CZ), ItalyDepartment of Pharmacy, University of Chieti—Pescara “G. d’Annunzio”, Via dei Vestini 31, 66100 Chieti, ItalyDepartment of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario “S. Venuta”, viale Europa, 88100 Germaneto (CZ), ItalyNational Council of Research (CNR), The Institute for Biomedical Research and Innovation, viale Europa, 88100 Germaneto (CZ), ItalyDepartment of Experimental and Clinical Medicine, University “Magna Græcia” of Catanzaro, Campus Universitario “S. Venuta”, viale Europa, 88100 Germaneto (CZ), ItalyThe topical administration of active compounds represents an advantageous strategy to reach the various skin components as well as its appendages. Pilosebaceous follicles are skin appendages originating in the deeper skin layers. They are very difficult to target, and hence higher active dosages are generally required to achieve effective biological responses, thus favoring the rise of side effects. The aim of this work was to design a supramolecular colloidal carrier, i.e., a liquid crystal nanocarrier, for the selective delivery of active compounds into the pilosebaceous follicle. This nanocarrier showed mean sizes of ~80 nm, a good stability, a negative surface charge, and great safety properties. In vitro studies highlighted its ability to contain and release different substances and to successfully permeate the skin. Minoxidil was encapsulated in the nanocarriers and the in vivo biological effect was compared with a conventional dosage form. Minoxidil-loaded liquid crystal nanocarrier was able to selectively reach the pilosebaceous follicle, thus allowing an increased biological effectiveness of the delivered active in terms of biological response, duration of the biological effects, and reduction of collaterals. Our investigation showed that liquid crystal nanocarriers represent a promising device for the treatment of different pilosebaceous follicular impairments/diseases.https://www.mdpi.com/1999-4923/12/11/1127liquid crystal nanocarrierstopical drug deliveryin vivoin vitrotransfollicularminoxidil |
| spellingShingle | Massimo Fresta Antonia Mancuso Maria Chiara Cristiano Konrad Urbanek Felisa Cilurzo Donato Cosco Michelangelo Iannone Donatella Paolino Targeting of the Pilosebaceous Follicle by Liquid Crystal Nanocarriers: In Vitro and In Vivo Effects of the Entrapped Minoxidil Pharmaceutics liquid crystal nanocarriers topical drug delivery in vivo in vitro transfollicular minoxidil |
| title | Targeting of the Pilosebaceous Follicle by Liquid Crystal Nanocarriers: In Vitro and In Vivo Effects of the Entrapped Minoxidil |
| title_full | Targeting of the Pilosebaceous Follicle by Liquid Crystal Nanocarriers: In Vitro and In Vivo Effects of the Entrapped Minoxidil |
| title_fullStr | Targeting of the Pilosebaceous Follicle by Liquid Crystal Nanocarriers: In Vitro and In Vivo Effects of the Entrapped Minoxidil |
| title_full_unstemmed | Targeting of the Pilosebaceous Follicle by Liquid Crystal Nanocarriers: In Vitro and In Vivo Effects of the Entrapped Minoxidil |
| title_short | Targeting of the Pilosebaceous Follicle by Liquid Crystal Nanocarriers: In Vitro and In Vivo Effects of the Entrapped Minoxidil |
| title_sort | targeting of the pilosebaceous follicle by liquid crystal nanocarriers in vitro and in vivo effects of the entrapped minoxidil |
| topic | liquid crystal nanocarriers topical drug delivery in vivo in vitro transfollicular minoxidil |
| url | https://www.mdpi.com/1999-4923/12/11/1127 |
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