Nanoengineered photoactive theranostic agents for cancer
Cancer has gained much attention because of slow development of advanced diagnostics and therapeutic strategies. So far, conventional procedures like surgery, radiation therapy and chemotherapy are only available options for cancer treatment which have various limitations. To overcome the limitation...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2021-07-01
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| Series: | Nanophotonics |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/nanoph-2021-0205 |
| _version_ | 1797987732105986048 |
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| author | Jain Nishant K. Chathoth Bavya M. Bhaskar Vinil S. Meena Himanshu Prasad Rajendra Srivastava Rohit |
| author_facet | Jain Nishant K. Chathoth Bavya M. Bhaskar Vinil S. Meena Himanshu Prasad Rajendra Srivastava Rohit |
| author_sort | Jain Nishant K. |
| collection | DOAJ |
| description | Cancer has gained much attention because of slow development of advanced diagnostics and therapeutic strategies. So far, conventional procedures like surgery, radiation therapy and chemotherapy are only available options for cancer treatment which have various limitations. To overcome the limitations of conventional procedures, nanodiagnostics, and therapeutics are emerging approaches for localized diagnosis and treatment of cancer nowadays. So far, various bio-mimicking and stimuli active cancer theranostic platforms have been established but they are limited only for animal studies and their clinical translational progress is slow. Among various cancer theranostics platforms, photoresponsive systems have shown promising outcomes for cancer theranostics applications due to their specific physicochemical properties, biocompatibility, multifunctionality etc. Moreover, these photothermal agents in combination with diagnostics probes and surface functional targeting moieties demonstrate their synergistic response for site selective imaging and ablating cancer cells/tumor. Photoactive principles are rife and with increasing access to light irradiation setups, more the discovery of photoactive products, more would be the success reaped in cancer battle. This review highlights recent developments in cancer nanotheranostics with a special focus on photoactive functional nanotheranostics. Moreover, the challenges involved in clinical translation of photoactive materials along with their application in vivid areas of cancer nanomedicine and elucidate the future implications on photoactive therapy have been addressed here. |
| first_indexed | 2024-04-11T07:51:24Z |
| format | Article |
| id | doaj.art-4bcb9b62f85c4811a04fe8b85028f6fa |
| institution | Directory Open Access Journal |
| issn | 2192-8614 |
| language | English |
| last_indexed | 2024-04-11T07:51:24Z |
| publishDate | 2021-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Nanophotonics |
| spelling | doaj.art-4bcb9b62f85c4811a04fe8b85028f6fa2022-12-22T04:36:03ZengDe GruyterNanophotonics2192-86142021-07-0110122973299710.1515/nanoph-2021-0205Nanoengineered photoactive theranostic agents for cancerJain Nishant K.0Chathoth Bavya M.1Bhaskar Vinil S.2Meena Himanshu3Prasad Rajendra4Srivastava Rohit5Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, IndiaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, IndiaDepartment of Anaesthesia, Saifee Hospital, Girgaon, Mumbai, 400004, IndiaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, IndiaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, IndiaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, IndiaCancer has gained much attention because of slow development of advanced diagnostics and therapeutic strategies. So far, conventional procedures like surgery, radiation therapy and chemotherapy are only available options for cancer treatment which have various limitations. To overcome the limitations of conventional procedures, nanodiagnostics, and therapeutics are emerging approaches for localized diagnosis and treatment of cancer nowadays. So far, various bio-mimicking and stimuli active cancer theranostic platforms have been established but they are limited only for animal studies and their clinical translational progress is slow. Among various cancer theranostics platforms, photoresponsive systems have shown promising outcomes for cancer theranostics applications due to their specific physicochemical properties, biocompatibility, multifunctionality etc. Moreover, these photothermal agents in combination with diagnostics probes and surface functional targeting moieties demonstrate their synergistic response for site selective imaging and ablating cancer cells/tumor. Photoactive principles are rife and with increasing access to light irradiation setups, more the discovery of photoactive products, more would be the success reaped in cancer battle. This review highlights recent developments in cancer nanotheranostics with a special focus on photoactive functional nanotheranostics. Moreover, the challenges involved in clinical translation of photoactive materials along with their application in vivid areas of cancer nanomedicine and elucidate the future implications on photoactive therapy have been addressed here.https://doi.org/10.1515/nanoph-2021-0205cancer therapynanotheranosticsphotoactive materialsphotodynamic probesphotothermal agents |
| spellingShingle | Jain Nishant K. Chathoth Bavya M. Bhaskar Vinil S. Meena Himanshu Prasad Rajendra Srivastava Rohit Nanoengineered photoactive theranostic agents for cancer Nanophotonics cancer therapy nanotheranostics photoactive materials photodynamic probes photothermal agents |
| title | Nanoengineered photoactive theranostic agents for cancer |
| title_full | Nanoengineered photoactive theranostic agents for cancer |
| title_fullStr | Nanoengineered photoactive theranostic agents for cancer |
| title_full_unstemmed | Nanoengineered photoactive theranostic agents for cancer |
| title_short | Nanoengineered photoactive theranostic agents for cancer |
| title_sort | nanoengineered photoactive theranostic agents for cancer |
| topic | cancer therapy nanotheranostics photoactive materials photodynamic probes photothermal agents |
| url | https://doi.org/10.1515/nanoph-2021-0205 |
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