INHERITED GENETIC SUSCEPTIBILITY TO BREAST CANCER IN PAKISTAN
Breast cancer is a heterogeneous disease. Several genetic, environmental and lifestyle factors are involved in the aetiology of this disease. Genetic risk factors include alterations (mutations) in genes conferring risks to develop breast cancer. Depending on the associated lifetime risks of this ma...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shaukat Khanum Memorial Trust
2018-07-01
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| Series: | Journal of Cancer and Allied Specialties |
| Online Access: | http://journals.sfu.ca/jcas/index.php/jcas/article/view/179 |
| _version_ | 1819005964675710976 |
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| author | Noor Muhammad Ramsha Nawaz Faiz Ali Khan Humaira Naeemi Muhammad Usman Rashid |
| author_facet | Noor Muhammad Ramsha Nawaz Faiz Ali Khan Humaira Naeemi Muhammad Usman Rashid |
| author_sort | Noor Muhammad |
| collection | DOAJ |
| description | Breast cancer is a heterogeneous disease. Several genetic, environmental and lifestyle factors are involved in the aetiology of this disease. Genetic risk factors include alterations (mutations) in genes conferring risks to develop breast cancer. Depending on the associated lifetime risks of this malignancy, these genes are categorised into high-, moderate- and low-risk genes. Women carrying mutations in these genes are at an increased risk to develop breast cancer, ovarian cancer and several other malignancies. Breast carcinoma is the most reported malignancy in Pakistani females. Pakistan is a developing country with most of its population living in rural areas; hence, optimal healthcare facilities are inadequate for the early diagnosis and prevention of this disease. Hence, identification of individuals carrying mutations is clinically relevant as different strategies are available for the early detection, risk reduction and better management of this malignancy. This review summarises the findings of the major studies conducted in Pakistan to investigate the contribution of breast cancer predisposing genes. Furthermore, implications of the current studies and future research potentials are discussed.
Key words: Breast cancer gene 1/2, breast cancer, checkpoint kinase 2, genetic susceptibility, Pakistan, RAD51C, tumour Protein p53, Vitamin D receptor |
| first_indexed | 2024-12-21T00:01:09Z |
| format | Article |
| id | doaj.art-4bcc2e47fa0940e48e2785f8e3d351e0 |
| institution | Directory Open Access Journal |
| issn | 2411-989X |
| language | English |
| last_indexed | 2024-12-21T00:01:09Z |
| publishDate | 2018-07-01 |
| publisher | Shaukat Khanum Memorial Trust |
| record_format | Article |
| series | Journal of Cancer and Allied Specialties |
| spelling | doaj.art-4bcc2e47fa0940e48e2785f8e3d351e02022-12-21T19:22:36ZengShaukat Khanum Memorial TrustJournal of Cancer and Allied Specialties2411-989X2018-07-014210.37029/jcas.v4i2.179INHERITED GENETIC SUSCEPTIBILITY TO BREAST CANCER IN PAKISTANNoor Muhammad0Ramsha Nawaz1Faiz Ali Khan2Humaira Naeemi3Muhammad Usman Rashid4Shaukat Khanum Memorial Cancer Hospital and Research Centre, LahoreShaukat Khanum Memorial Cancer Hospital and Research Centre, LahoreShaukat Khanum Memorial Cancer Hospital and Research Centre, LahoreShaukat Khanum Memorial Cancer Hospital and Research Centre, LahoreShaukat Khanum Memorial Cancer Hospital and Research Centre, LahoreBreast cancer is a heterogeneous disease. Several genetic, environmental and lifestyle factors are involved in the aetiology of this disease. Genetic risk factors include alterations (mutations) in genes conferring risks to develop breast cancer. Depending on the associated lifetime risks of this malignancy, these genes are categorised into high-, moderate- and low-risk genes. Women carrying mutations in these genes are at an increased risk to develop breast cancer, ovarian cancer and several other malignancies. Breast carcinoma is the most reported malignancy in Pakistani females. Pakistan is a developing country with most of its population living in rural areas; hence, optimal healthcare facilities are inadequate for the early diagnosis and prevention of this disease. Hence, identification of individuals carrying mutations is clinically relevant as different strategies are available for the early detection, risk reduction and better management of this malignancy. This review summarises the findings of the major studies conducted in Pakistan to investigate the contribution of breast cancer predisposing genes. Furthermore, implications of the current studies and future research potentials are discussed. Key words: Breast cancer gene 1/2, breast cancer, checkpoint kinase 2, genetic susceptibility, Pakistan, RAD51C, tumour Protein p53, Vitamin D receptorhttp://journals.sfu.ca/jcas/index.php/jcas/article/view/179 |
| spellingShingle | Noor Muhammad Ramsha Nawaz Faiz Ali Khan Humaira Naeemi Muhammad Usman Rashid INHERITED GENETIC SUSCEPTIBILITY TO BREAST CANCER IN PAKISTAN Journal of Cancer and Allied Specialties |
| title | INHERITED GENETIC SUSCEPTIBILITY TO BREAST CANCER IN PAKISTAN |
| title_full | INHERITED GENETIC SUSCEPTIBILITY TO BREAST CANCER IN PAKISTAN |
| title_fullStr | INHERITED GENETIC SUSCEPTIBILITY TO BREAST CANCER IN PAKISTAN |
| title_full_unstemmed | INHERITED GENETIC SUSCEPTIBILITY TO BREAST CANCER IN PAKISTAN |
| title_short | INHERITED GENETIC SUSCEPTIBILITY TO BREAST CANCER IN PAKISTAN |
| title_sort | inherited genetic susceptibility to breast cancer in pakistan |
| url | http://journals.sfu.ca/jcas/index.php/jcas/article/view/179 |
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