Contributions of Emphysema and Functional Small Airway Disease on Intrapulmonary Vascular Volume in COPD
Xiaoqi Huang,1,* Weiling Yin,1,* Min Shen,1 Xionghui Wang,1 Tao Ren,1 Lei Wang,1 Min Liu,2 Youmin Guo1 1Department of Radiology, Yan’an University Affiliated Hospital, Yan’an, People’s Republic of China; 2Department of Radiology, China-Japan Friendship Hospital, Beijing, People’s Rep...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-08-01
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| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/contributions-of-emphysema-and-functional-small-airway-disease-on-intr-peer-reviewed-fulltext-article-COPD |
| _version_ | 1798038698944626688 |
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| author | Huang X Yin W Shen M Wang X Ren T Wang L Liu M Guo Y |
| author_facet | Huang X Yin W Shen M Wang X Ren T Wang L Liu M Guo Y |
| author_sort | Huang X |
| collection | DOAJ |
| description | Xiaoqi Huang,1,* Weiling Yin,1,* Min Shen,1 Xionghui Wang,1 Tao Ren,1 Lei Wang,1 Min Liu,2 Youmin Guo1 1Department of Radiology, Yan’an University Affiliated Hospital, Yan’an, People’s Republic of China; 2Department of Radiology, China-Japan Friendship Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Youmin Guo, Department of Radiology, Yan’an University Affiliated Hospital, Yan’an, People’s Republic of China, Tel +86-13909187113, Email cjr.guoyoumin@vip.163.comBackground: Previous studies have demonstrated that there is a certain correlation between emphysema and changes in pulmonary small blood vessels in patients with chronic obstructive pulmonary disease (COPD), but most of them were limited to the investigation of the inspiratory phase. The emphysema indicators need to be further optimized. Based on the parametric response mapping (PRM) method, this study aimed to investigate the effect of emphysema and functional small airway disease on intrapulmonary vascular volume (IPVV).Methods: This retrospective study enrolled 63 healthy subjects and 47 COPD patients, who underwent both inspiratory and expiratory CT scans of the chest and pulmonary function tests (PFTs). Inspiratory and expiratory IPVV were measured by using an automatic pulmonary vessels integration segmentation approach, the ratio of emphysema volume (Emph%), functional small airway disease volume (fsAD%), and normal areas volume (Normal%) were quantified by the PRM method for biphasic CT scans. The participants were grouped according to PFTs. Analysis of variance (ANOVA) and Kruskal–Wallis H-test were used to analyze the differences in indicators between different groups. Then, Spearman’s rank correlation coefficients were used to analyze the correlation between Emph%, fsAD%, Normal%, PFTs, and IPVV. Finally, multiple linear regression was applied to analyze the effects of Emph% and fsAD% on IPVV.Results: Differences were found in age, body mass index (BMI), smoking index, FEV1%, FEV1/forced vital capacity (FVC), expiratory IPVV, IPVV relative value, IPVV difference value, Emph%, fsAD%, and Normal% between the groups (P< 0.05). A strong correlation was established between the outcomes of PFTs and quantitative CT indexes. Finally, the effect of Emph% was more significant than that of fsAD% on expiratory IPVV, IPVV difference value, and IPVV relative value.Conclusion: IPVV may have a potential value in assessing COPD severity and is significantly affected by emphysema.Keywords: chronic obstructive pulmonary disease, intrapulmonary vascular volume, emphysema, functional small airway disease, parametric response mapping method |
| first_indexed | 2024-04-11T21:43:50Z |
| format | Article |
| id | doaj.art-4bcd9379ae2648c2b9c4d733c106e5c7 |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-04-11T21:43:50Z |
| publishDate | 2022-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-4bcd9379ae2648c2b9c4d733c106e5c72022-12-22T04:01:28ZengDove Medical PressInternational Journal of COPD1178-20052022-08-01Volume 171951196177677Contributions of Emphysema and Functional Small Airway Disease on Intrapulmonary Vascular Volume in COPDHuang XYin WShen MWang XRen TWang LLiu MGuo YXiaoqi Huang,1,* Weiling Yin,1,* Min Shen,1 Xionghui Wang,1 Tao Ren,1 Lei Wang,1 Min Liu,2 Youmin Guo1 1Department of Radiology, Yan’an University Affiliated Hospital, Yan’an, People’s Republic of China; 2Department of Radiology, China-Japan Friendship Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Youmin Guo, Department of Radiology, Yan’an University Affiliated Hospital, Yan’an, People’s Republic of China, Tel +86-13909187113, Email cjr.guoyoumin@vip.163.comBackground: Previous studies have demonstrated that there is a certain correlation between emphysema and changes in pulmonary small blood vessels in patients with chronic obstructive pulmonary disease (COPD), but most of them were limited to the investigation of the inspiratory phase. The emphysema indicators need to be further optimized. Based on the parametric response mapping (PRM) method, this study aimed to investigate the effect of emphysema and functional small airway disease on intrapulmonary vascular volume (IPVV).Methods: This retrospective study enrolled 63 healthy subjects and 47 COPD patients, who underwent both inspiratory and expiratory CT scans of the chest and pulmonary function tests (PFTs). Inspiratory and expiratory IPVV were measured by using an automatic pulmonary vessels integration segmentation approach, the ratio of emphysema volume (Emph%), functional small airway disease volume (fsAD%), and normal areas volume (Normal%) were quantified by the PRM method for biphasic CT scans. The participants were grouped according to PFTs. Analysis of variance (ANOVA) and Kruskal–Wallis H-test were used to analyze the differences in indicators between different groups. Then, Spearman’s rank correlation coefficients were used to analyze the correlation between Emph%, fsAD%, Normal%, PFTs, and IPVV. Finally, multiple linear regression was applied to analyze the effects of Emph% and fsAD% on IPVV.Results: Differences were found in age, body mass index (BMI), smoking index, FEV1%, FEV1/forced vital capacity (FVC), expiratory IPVV, IPVV relative value, IPVV difference value, Emph%, fsAD%, and Normal% between the groups (P< 0.05). A strong correlation was established between the outcomes of PFTs and quantitative CT indexes. Finally, the effect of Emph% was more significant than that of fsAD% on expiratory IPVV, IPVV difference value, and IPVV relative value.Conclusion: IPVV may have a potential value in assessing COPD severity and is significantly affected by emphysema.Keywords: chronic obstructive pulmonary disease, intrapulmonary vascular volume, emphysema, functional small airway disease, parametric response mapping methodhttps://www.dovepress.com/contributions-of-emphysema-and-functional-small-airway-disease-on-intr-peer-reviewed-fulltext-article-COPDchronic obstructive pulmonary diseaseintrapulmonary vascular volumeemphysemafunctional small airway diseaseparametric response mapping method |
| spellingShingle | Huang X Yin W Shen M Wang X Ren T Wang L Liu M Guo Y Contributions of Emphysema and Functional Small Airway Disease on Intrapulmonary Vascular Volume in COPD International Journal of COPD chronic obstructive pulmonary disease intrapulmonary vascular volume emphysema functional small airway disease parametric response mapping method |
| title | Contributions of Emphysema and Functional Small Airway Disease on Intrapulmonary Vascular Volume in COPD |
| title_full | Contributions of Emphysema and Functional Small Airway Disease on Intrapulmonary Vascular Volume in COPD |
| title_fullStr | Contributions of Emphysema and Functional Small Airway Disease on Intrapulmonary Vascular Volume in COPD |
| title_full_unstemmed | Contributions of Emphysema and Functional Small Airway Disease on Intrapulmonary Vascular Volume in COPD |
| title_short | Contributions of Emphysema and Functional Small Airway Disease on Intrapulmonary Vascular Volume in COPD |
| title_sort | contributions of emphysema and functional small airway disease on intrapulmonary vascular volume in copd |
| topic | chronic obstructive pulmonary disease intrapulmonary vascular volume emphysema functional small airway disease parametric response mapping method |
| url | https://www.dovepress.com/contributions-of-emphysema-and-functional-small-airway-disease-on-intr-peer-reviewed-fulltext-article-COPD |
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