Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders
Purpose: We investigated the neural correlates of emotion regulation and -reactivity in adult unaffected monozygotic twins with a co-twin history of unipolar or bipolar disorder (high-risk), remitted or partially remitted twins with a personal history of unipolar or bipolar disorder (affected) and t...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218303462 |
| _version_ | 1818924012314558464 |
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| author | Iselin Meluken Ninja Meinhard Ottesen K. Luan Phan Phillipe R. Goldin Martina Di Simplicio Julian Macoveanu Hartwig Roman Siebner Lars Vedel Kessing Maj Vinberg Kamilla Woznica Miskowiak |
| author_facet | Iselin Meluken Ninja Meinhard Ottesen K. Luan Phan Phillipe R. Goldin Martina Di Simplicio Julian Macoveanu Hartwig Roman Siebner Lars Vedel Kessing Maj Vinberg Kamilla Woznica Miskowiak |
| author_sort | Iselin Meluken |
| collection | DOAJ |
| description | Purpose: We investigated the neural correlates of emotion regulation and -reactivity in adult unaffected monozygotic twins with a co-twin history of unipolar or bipolar disorder (high-risk), remitted or partially remitted twins with a personal history of unipolar or bipolar disorder (affected) and twins with no personal or first-degree family history of unipolar or bipolar disorder (low-risk). Methods: We assessed 37 high-risk, 56 affected and 28 low-risk participants. Participants viewed unpleasant and neutral pictures during functional magnetic resonance imaging and were instructed to down-regulate their emotional response through reappraisal or mental imagery, as well as to maintain the elicited emotion. Results: After adjusting for subsyndromal depressive symptoms, bilateral supplementary motor areas, posterior dorsal anterior cingulate cortices and the left frontal eye field showed less activity during reappraisal of unpleasant pictures in high-risk than low-risk participants. Notably, affected participants did not differ from high-risk or low-risk participants in neural response during reappraisal. There were no group differences in ventrolateral prefrontal cortex seed based functional connectivity during reappraisal or neural response during mental imagery or emotional reactivity. Conclusion: Lesser response in dorsal midline areas might reflect familial risk related abnormalities during down regulation of emotional reactivity through reappraisal. Keywords: Mood disorder, Monozygotic twins, Endophenotypes, Cognitive neuroscience, Magnetic resonance imaging |
| first_indexed | 2024-12-20T02:18:34Z |
| format | Article |
| id | doaj.art-4bcdbe227b834658a08501415a477fba |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-20T02:18:34Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-4bcdbe227b834658a08501415a477fba2022-12-21T19:56:53ZengElsevierNeuroImage: Clinical2213-15822019-01-0121Neural response during emotion regulation in monozygotic twins at high familial risk of affective disordersIselin Meluken0Ninja Meinhard Ottesen1K. Luan Phan2Phillipe R. Goldin3Martina Di Simplicio4Julian Macoveanu5Hartwig Roman Siebner6Lars Vedel Kessing7Maj Vinberg8Kamilla Woznica Miskowiak9Copenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, University Hospital of Copenhagen, Rigshospitalet, 6233, Blegdamsvej 9, 2100 Copenhagen, Denmark; Danish Research Centre of Magnetic Resonance, Copenhagen University Hospital, Kettegård Alle 30, 2650 Hvidovre, DenmarkCopenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, University Hospital of Copenhagen, Rigshospitalet, 6233, Blegdamsvej 9, 2100 Copenhagen, DenmarkDepartment of Psychiatry, University of Illinois at Chicago, 1747 Roosevelt Rd, Chicago, IL 60608, USAUniversity of California Davis, 135 Young Hall, One Shields Avenue, CA 95616, USACentre for Psychiatry, Imperial College London, South Kensington Campus, London SW7 2AZ, UKCopenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, University Hospital of Copenhagen, Rigshospitalet, 6233, Blegdamsvej 9, 2100 Copenhagen, Denmark; Danish Research Centre of Magnetic Resonance, Copenhagen University Hospital, Kettegård Alle 30, 2650 Hvidovre, DenmarkDanish Research Centre of Magnetic Resonance, Copenhagen University Hospital, Kettegård Alle 30, 2650 Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital, Bispebjerg, University of Copenhagen, Hvidovre Hospital, Kettegård Alle 30, 2650 Hvidovre, DenmarkCopenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, University Hospital of Copenhagen, Rigshospitalet, 6233, Blegdamsvej 9, 2100 Copenhagen, DenmarkCopenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, University Hospital of Copenhagen, Rigshospitalet, 6233, Blegdamsvej 9, 2100 Copenhagen, DenmarkCopenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, University Hospital of Copenhagen, Rigshospitalet, 6233, Blegdamsvej 9, 2100 Copenhagen, Denmark; Department of Psychology, University of Copenhagen, Øster Farimagsgade 2A, 1353 København K, Denmark; Corresponding author at: Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.Purpose: We investigated the neural correlates of emotion regulation and -reactivity in adult unaffected monozygotic twins with a co-twin history of unipolar or bipolar disorder (high-risk), remitted or partially remitted twins with a personal history of unipolar or bipolar disorder (affected) and twins with no personal or first-degree family history of unipolar or bipolar disorder (low-risk). Methods: We assessed 37 high-risk, 56 affected and 28 low-risk participants. Participants viewed unpleasant and neutral pictures during functional magnetic resonance imaging and were instructed to down-regulate their emotional response through reappraisal or mental imagery, as well as to maintain the elicited emotion. Results: After adjusting for subsyndromal depressive symptoms, bilateral supplementary motor areas, posterior dorsal anterior cingulate cortices and the left frontal eye field showed less activity during reappraisal of unpleasant pictures in high-risk than low-risk participants. Notably, affected participants did not differ from high-risk or low-risk participants in neural response during reappraisal. There were no group differences in ventrolateral prefrontal cortex seed based functional connectivity during reappraisal or neural response during mental imagery or emotional reactivity. Conclusion: Lesser response in dorsal midline areas might reflect familial risk related abnormalities during down regulation of emotional reactivity through reappraisal. Keywords: Mood disorder, Monozygotic twins, Endophenotypes, Cognitive neuroscience, Magnetic resonance imaginghttp://www.sciencedirect.com/science/article/pii/S2213158218303462 |
| spellingShingle | Iselin Meluken Ninja Meinhard Ottesen K. Luan Phan Phillipe R. Goldin Martina Di Simplicio Julian Macoveanu Hartwig Roman Siebner Lars Vedel Kessing Maj Vinberg Kamilla Woznica Miskowiak Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders NeuroImage: Clinical |
| title | Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders |
| title_full | Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders |
| title_fullStr | Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders |
| title_full_unstemmed | Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders |
| title_short | Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders |
| title_sort | neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders |
| url | http://www.sciencedirect.com/science/article/pii/S2213158218303462 |
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