Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study.
The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecula...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4466435?pdf=render |
| _version_ | 1818151571810156544 |
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| author | Ming-ming Guo Xue-ning Duan Shu-de Cui Fu-guo Tian Xu-chen Cao Cui-zhi Geng Zhi-min Fan Xiang Wang Shu Wang Hong-chuan Jiang Jian-guo Zhang Feng Jin Jin-hai Tang Hong Liang Zhen-lin Yang Hai-bo Wang Qi-tang Wang Guo-lou Li Liang Li Shi-guang Zhu Wen-shu Zuo Li-yuan Liu Lu Wang Dan-dan Ma Shu-chen Liu Yu-juan Xiang Lu Liu Chun-miao Ye Wen-zhong Zhou Fei Wang Li-xiang Yu Zhong-bing Ma Zhi-gang Yu |
| author_facet | Ming-ming Guo Xue-ning Duan Shu-de Cui Fu-guo Tian Xu-chen Cao Cui-zhi Geng Zhi-min Fan Xiang Wang Shu Wang Hong-chuan Jiang Jian-guo Zhang Feng Jin Jin-hai Tang Hong Liang Zhen-lin Yang Hai-bo Wang Qi-tang Wang Guo-lou Li Liang Li Shi-guang Zhu Wen-shu Zuo Li-yuan Liu Lu Wang Dan-dan Ma Shu-chen Liu Yu-juan Xiang Lu Liu Chun-miao Ye Wen-zhong Zhou Fei Wang Li-xiang Yu Zhong-bing Ma Zhi-gang Yu |
| author_sort | Ming-ming Guo |
| collection | DOAJ |
| description | The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecular weight (HMW) adiponectin in a case-control study (1167 sets). Higher circulating HMW adiponectin was negatively associated with breast cancer risk after adjusting for menopausal status and family history of breast cancer (P=0.024). We analyzed the relationship between adiponectin and breast cancer risk in 6 subgroups. Higher circulating HMW adiponectin was also negatively associated with breast cancer risk (P=0.020, 0.014, 0.035) in the subgroups of postmenopausal women, negative family history of breast cancer, BMI>=24.0. Total adiponectin was positively associated with breast cancer (P=0.028) in the subgroup of BMI<=24.0. Higher HMW/total adiponectin ratio was negatively associated with breast cancer (P=0.019) in the subgroup of postmenopausal women. Interestingly, in the subgroup of women with family history of breast cancer, higher circulating total and HMW adiponectin were positively associated with breast cancer risk (P=0.034, 0.0116). This study showed different forms of circulating adiponectin levels might play different roles in breast cancer risk. A higher circulating HMW adiponectin is associated with a decreased breast cancer risk, especially in postmenopausal, without family history of breast cancer or BMI>=24.0 subgroups, whereas higher circulating HMW adiponectin levels is a risk factor in women with a family history of breast cancer. Further investigation of different forms of adiponectin on breast cancer risk is needed. |
| first_indexed | 2024-12-11T13:40:57Z |
| format | Article |
| id | doaj.art-4bcfc6076e704e7c911c9b5b027ce1c7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T13:40:57Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4bcfc6076e704e7c911c9b5b027ce1c72022-12-22T01:04:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e012924610.1371/journal.pone.0129246Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study.Ming-ming GuoXue-ning DuanShu-de CuiFu-guo TianXu-chen CaoCui-zhi GengZhi-min FanXiang WangShu WangHong-chuan JiangJian-guo ZhangFeng JinJin-hai TangHong LiangZhen-lin YangHai-bo WangQi-tang WangGuo-lou LiLiang LiShi-guang ZhuWen-shu ZuoLi-yuan LiuLu WangDan-dan MaShu-chen LiuYu-juan XiangLu LiuChun-miao YeWen-zhong ZhouFei WangLi-xiang YuZhong-bing MaZhi-gang YuThe level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecular weight (HMW) adiponectin in a case-control study (1167 sets). Higher circulating HMW adiponectin was negatively associated with breast cancer risk after adjusting for menopausal status and family history of breast cancer (P=0.024). We analyzed the relationship between adiponectin and breast cancer risk in 6 subgroups. Higher circulating HMW adiponectin was also negatively associated with breast cancer risk (P=0.020, 0.014, 0.035) in the subgroups of postmenopausal women, negative family history of breast cancer, BMI>=24.0. Total adiponectin was positively associated with breast cancer (P=0.028) in the subgroup of BMI<=24.0. Higher HMW/total adiponectin ratio was negatively associated with breast cancer (P=0.019) in the subgroup of postmenopausal women. Interestingly, in the subgroup of women with family history of breast cancer, higher circulating total and HMW adiponectin were positively associated with breast cancer risk (P=0.034, 0.0116). This study showed different forms of circulating adiponectin levels might play different roles in breast cancer risk. A higher circulating HMW adiponectin is associated with a decreased breast cancer risk, especially in postmenopausal, without family history of breast cancer or BMI>=24.0 subgroups, whereas higher circulating HMW adiponectin levels is a risk factor in women with a family history of breast cancer. Further investigation of different forms of adiponectin on breast cancer risk is needed.http://europepmc.org/articles/PMC4466435?pdf=render |
| spellingShingle | Ming-ming Guo Xue-ning Duan Shu-de Cui Fu-guo Tian Xu-chen Cao Cui-zhi Geng Zhi-min Fan Xiang Wang Shu Wang Hong-chuan Jiang Jian-guo Zhang Feng Jin Jin-hai Tang Hong Liang Zhen-lin Yang Hai-bo Wang Qi-tang Wang Guo-lou Li Liang Li Shi-guang Zhu Wen-shu Zuo Li-yuan Liu Lu Wang Dan-dan Ma Shu-chen Liu Yu-juan Xiang Lu Liu Chun-miao Ye Wen-zhong Zhou Fei Wang Li-xiang Yu Zhong-bing Ma Zhi-gang Yu Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study. PLoS ONE |
| title | Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study. |
| title_full | Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study. |
| title_fullStr | Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study. |
| title_full_unstemmed | Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study. |
| title_short | Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study. |
| title_sort | circulating high molecular weight hmw adiponectin level is related with breast cancer risk better than total adiponectin a case control study |
| url | http://europepmc.org/articles/PMC4466435?pdf=render |
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