High-Mobility Group Box 1 Contributes to Cerebral Cortex Injury in a Neonatal Hypoxic-Ischemic Rat Model by Regulating the Phenotypic Polarization of Microglia

High-Mobility Group Box 1 Contributes to Cerebral Cortex Injury in a Neonatal Hypoxic-Ischemic Rat Model by Regulating the Phenotypic Polarization of Microglia

Neonatal hypoxic-ischemic (HI) encephalopathy is a severe disease for which there is currently no curative treatment. Recent evidence suggests that high-mobility group box 1 (HMGB1) protein can promote neuroinflammation after stroke in adult rodents, but its role in perinatal hypoxic-ischemic brain...

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Bibliographic Details
Main Authors: Yanyan Sun, Mingyan Hei, Zhihui Fang, Zhen Tang, Bo Wang, Na Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
hypoxic-ischemic (HI)
HMGB1
microglia
polarization
cerebral cortex injury
neonatal
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00506/full

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