Association between Endocrine Therapy and Weight Gain after Breast Cancer Diagnosis among Japanese Patients: A Retrospective Cohort Study
Background: This study aimed to investigate the association between endocrine therapy and weight gain with a history of breast cancer. Methods: This was a retrospective cohort study. Recruited patients consisted of those receiving endocrine therapy and those not receiving endocrine therapy. Weight a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
|
| Series: | Medical Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3271/9/3/50 |
| _version_ | 1797518299460796416 |
|---|---|
| author | Koki Okumatsu Hideko Yamauchi Rina Kotake Masahiko Gosho Yoshio Nakata |
| author_facet | Koki Okumatsu Hideko Yamauchi Rina Kotake Masahiko Gosho Yoshio Nakata |
| author_sort | Koki Okumatsu |
| collection | DOAJ |
| description | Background: This study aimed to investigate the association between endocrine therapy and weight gain with a history of breast cancer. Methods: This was a retrospective cohort study. Recruited patients consisted of those receiving endocrine therapy and those not receiving endocrine therapy. Weight at diagnosis was collected from medical records, and current body mass was measured using a digital scale (time since diagnosis was 4.0 ± 1.9 years). Moreover, we measured current physical activity using an accelerometer and dietary intake using a validated questionnaire. The primary analysis was a <i>t</i>-test for the body-mass change after diagnosis between the two groups. Results: We recruited 300 patients and collected data from 292. Mean weight gain after diagnosis was 1.3 ± 3.9 kg, and the change in body mass of patients taking endocrine therapy (1.3 ± 4.0 kg) was not significantly different from that of patients not taking endocrine therapy (1.4 ± 3.8 kg, <i>p</i> = 0.92). There was no association of endocrine therapy, physical activity, and dietary intake with a 5% weight gain after adjusting confounding factors (e.g., breast cancer stage and chemotherapy). Conclusions: Caution is required with generalization because of sampling bias and ethnic differences. |
| first_indexed | 2024-03-10T07:26:54Z |
| format | Article |
| id | doaj.art-4bd060b545c34d718b3b3b2720836c0a |
| institution | Directory Open Access Journal |
| issn | 2076-3271 |
| language | English |
| last_indexed | 2024-03-10T07:26:54Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences |
| spelling | doaj.art-4bd060b545c34d718b3b3b2720836c0a2023-11-22T14:09:39ZengMDPI AGMedical Sciences2076-32712021-07-01935010.3390/medsci9030050Association between Endocrine Therapy and Weight Gain after Breast Cancer Diagnosis among Japanese Patients: A Retrospective Cohort StudyKoki Okumatsu0Hideko Yamauchi1Rina Kotake2Masahiko Gosho3Yoshio Nakata4Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, JapanDepartment of Breast Surgical Oncology, St. Luke’s International Hospital, 9-1 Akashicho, Chuo-ku, Tokyo 104-8560, JapanDepartment of Breast Surgical Oncology, St. Luke’s International Hospital, 9-1 Akashicho, Chuo-ku, Tokyo 104-8560, JapanDepartment of Biostatistics, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, JapanFaculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, JapanBackground: This study aimed to investigate the association between endocrine therapy and weight gain with a history of breast cancer. Methods: This was a retrospective cohort study. Recruited patients consisted of those receiving endocrine therapy and those not receiving endocrine therapy. Weight at diagnosis was collected from medical records, and current body mass was measured using a digital scale (time since diagnosis was 4.0 ± 1.9 years). Moreover, we measured current physical activity using an accelerometer and dietary intake using a validated questionnaire. The primary analysis was a <i>t</i>-test for the body-mass change after diagnosis between the two groups. Results: We recruited 300 patients and collected data from 292. Mean weight gain after diagnosis was 1.3 ± 3.9 kg, and the change in body mass of patients taking endocrine therapy (1.3 ± 4.0 kg) was not significantly different from that of patients not taking endocrine therapy (1.4 ± 3.8 kg, <i>p</i> = 0.92). There was no association of endocrine therapy, physical activity, and dietary intake with a 5% weight gain after adjusting confounding factors (e.g., breast cancer stage and chemotherapy). Conclusions: Caution is required with generalization because of sampling bias and ethnic differences.https://www.mdpi.com/2076-3271/9/3/50cancer survivorsbody weight changeexerciseeating |
| spellingShingle | Koki Okumatsu Hideko Yamauchi Rina Kotake Masahiko Gosho Yoshio Nakata Association between Endocrine Therapy and Weight Gain after Breast Cancer Diagnosis among Japanese Patients: A Retrospective Cohort Study Medical Sciences cancer survivors body weight change exercise eating |
| title | Association between Endocrine Therapy and Weight Gain after Breast Cancer Diagnosis among Japanese Patients: A Retrospective Cohort Study |
| title_full | Association between Endocrine Therapy and Weight Gain after Breast Cancer Diagnosis among Japanese Patients: A Retrospective Cohort Study |
| title_fullStr | Association between Endocrine Therapy and Weight Gain after Breast Cancer Diagnosis among Japanese Patients: A Retrospective Cohort Study |
| title_full_unstemmed | Association between Endocrine Therapy and Weight Gain after Breast Cancer Diagnosis among Japanese Patients: A Retrospective Cohort Study |
| title_short | Association between Endocrine Therapy and Weight Gain after Breast Cancer Diagnosis among Japanese Patients: A Retrospective Cohort Study |
| title_sort | association between endocrine therapy and weight gain after breast cancer diagnosis among japanese patients a retrospective cohort study |
| topic | cancer survivors body weight change exercise eating |
| url | https://www.mdpi.com/2076-3271/9/3/50 |
| work_keys_str_mv | AT kokiokumatsu associationbetweenendocrinetherapyandweightgainafterbreastcancerdiagnosisamongjapanesepatientsaretrospectivecohortstudy AT hidekoyamauchi associationbetweenendocrinetherapyandweightgainafterbreastcancerdiagnosisamongjapanesepatientsaretrospectivecohortstudy AT rinakotake associationbetweenendocrinetherapyandweightgainafterbreastcancerdiagnosisamongjapanesepatientsaretrospectivecohortstudy AT masahikogosho associationbetweenendocrinetherapyandweightgainafterbreastcancerdiagnosisamongjapanesepatientsaretrospectivecohortstudy AT yoshionakata associationbetweenendocrinetherapyandweightgainafterbreastcancerdiagnosisamongjapanesepatientsaretrospectivecohortstudy |