Move or Die: the Fate of the Tax Oncoprotein of HTLV-1

Move or Die: the Fate of the Tax Oncoprotein of HTLV-1

The HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select cellular genes via activation of cellular pathways and perturbation of both cell cycle control mech...

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Bibliographic Details
Main Authors: Françoise Bex, Isabelle Lamsoul, Julie Lodewick
Format: Article
Language:English
Published: MDPI AG 2011-06-01
Series:Viruses
Subjects:
HTLV-1
Tax
retrovirus
signal transduction
NF-kB
nuclear bodies
intracellular trafficking
posttranslational modifications
leukemia
Online Access:http://www.mdpi.com/1999-4915/3/6/829/
Description
Summary:The HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select cellular genes via activation of cellular pathways and perturbation of both cell cycle control mechanisms and apoptotic signals. The recent discovery that Tax undergoes a hierarchical sequence of posttranslational modifications that control its intracellular localization provides provocative insights into the mechanisms regulating Tax transcriptional and transforming activities.
ISSN:1999-4915

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