Move or Die: the Fate of the Tax Oncoprotein of HTLV-1
The HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select cellular genes via activation of cellular pathways and perturbation of both cell cycle control mech...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-06-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/3/6/829/ |
| _version_ | 1819053290020667392 |
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| author | Françoise Bex Isabelle Lamsoul Julie Lodewick |
| author_facet | Françoise Bex Isabelle Lamsoul Julie Lodewick |
| author_sort | Françoise Bex |
| collection | DOAJ |
| description | The HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select cellular genes via activation of cellular pathways and perturbation of both cell cycle control mechanisms and apoptotic signals. The recent discovery that Tax undergoes a hierarchical sequence of posttranslational modifications that control its intracellular localization provides provocative insights into the mechanisms regulating Tax transcriptional and transforming activities. |
| first_indexed | 2024-12-21T12:33:22Z |
| format | Article |
| id | doaj.art-4bd1bfa4618b4145a76040fed2a4abae |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-21T12:33:22Z |
| publishDate | 2011-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-4bd1bfa4618b4145a76040fed2a4abae2022-12-21T19:03:58ZengMDPI AGViruses1999-49152011-06-013682985710.3390/v3060829Move or Die: the Fate of the Tax Oncoprotein of HTLV-1Françoise BexIsabelle LamsoulJulie LodewickThe HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select cellular genes via activation of cellular pathways and perturbation of both cell cycle control mechanisms and apoptotic signals. The recent discovery that Tax undergoes a hierarchical sequence of posttranslational modifications that control its intracellular localization provides provocative insights into the mechanisms regulating Tax transcriptional and transforming activities.http://www.mdpi.com/1999-4915/3/6/829/HTLV-1Taxretrovirussignal transductionNF-kBnuclear bodiesintracellular traffickingposttranslational modificationsleukemia |
| spellingShingle | Françoise Bex Isabelle Lamsoul Julie Lodewick Move or Die: the Fate of the Tax Oncoprotein of HTLV-1 Viruses HTLV-1 Tax retrovirus signal transduction NF-kB nuclear bodies intracellular trafficking posttranslational modifications leukemia |
| title | Move or Die: the Fate of the Tax Oncoprotein of HTLV-1 |
| title_full | Move or Die: the Fate of the Tax Oncoprotein of HTLV-1 |
| title_fullStr | Move or Die: the Fate of the Tax Oncoprotein of HTLV-1 |
| title_full_unstemmed | Move or Die: the Fate of the Tax Oncoprotein of HTLV-1 |
| title_short | Move or Die: the Fate of the Tax Oncoprotein of HTLV-1 |
| title_sort | move or die the fate of the tax oncoprotein of htlv 1 |
| topic | HTLV-1 Tax retrovirus signal transduction NF-kB nuclear bodies intracellular trafficking posttranslational modifications leukemia |
| url | http://www.mdpi.com/1999-4915/3/6/829/ |
| work_keys_str_mv | AT francoisebex moveordiethefateofthetaxoncoproteinofhtlv1 AT isabellelamsoul moveordiethefateofthetaxoncoproteinofhtlv1 AT julielodewick moveordiethefateofthetaxoncoproteinofhtlv1 |