Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation
A short isoform of the Tet1 enzyme (Tet1s) that oxidizes the DNA 5-methylcytosine (5mC) mark is overexpressed in tumors. Here the authors show Tet1s, but not full length Tet1, changes localization over the cell cycle upon ubiquitination and Uhrf1 interaction and is targeted to heterochromatin during...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32799-8 |
| _version_ | 1828114375258406912 |
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| author | María Arroyo Florian D. Hastert Andreas Zhadan Florian Schelter Susanne Zimbelmann Cathia Rausch Anne K. Ludwig Thomas Carell M. Cristina Cardoso |
| author_facet | María Arroyo Florian D. Hastert Andreas Zhadan Florian Schelter Susanne Zimbelmann Cathia Rausch Anne K. Ludwig Thomas Carell M. Cristina Cardoso |
| author_sort | María Arroyo |
| collection | DOAJ |
| description | A short isoform of the Tet1 enzyme (Tet1s) that oxidizes the DNA 5-methylcytosine (5mC) mark is overexpressed in tumors. Here the authors show Tet1s, but not full length Tet1, changes localization over the cell cycle upon ubiquitination and Uhrf1 interaction and is targeted to heterochromatin during S-phase. This leads to 5mC oxidation and loss of DNA methylation in heterochromatin. |
| first_indexed | 2024-04-11T12:23:31Z |
| format | Article |
| id | doaj.art-4bd2bce040994572835707652c0ebd76 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T12:23:31Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4bd2bce040994572835707652c0ebd762022-12-22T04:24:01ZengNature PortfolioNature Communications2041-17232022-09-0113112810.1038/s41467-022-32799-8Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidationMaría Arroyo0Florian D. Hastert1Andreas Zhadan2Florian Schelter3Susanne Zimbelmann4Cathia Rausch5Anne K. Ludwig6Thomas Carell7M. Cristina Cardoso8Cell Biology and Epigenetics, Department of Biology, Technical University of DarmstadtCell Biology and Epigenetics, Department of Biology, Technical University of DarmstadtCell Biology and Epigenetics, Department of Biology, Technical University of DarmstadtDepartment of Chemistry, Ludwig Maximilians UniversityCell Biology and Epigenetics, Department of Biology, Technical University of DarmstadtCell Biology and Epigenetics, Department of Biology, Technical University of DarmstadtCell Biology and Epigenetics, Department of Biology, Technical University of DarmstadtDepartment of Chemistry, Ludwig Maximilians UniversityCell Biology and Epigenetics, Department of Biology, Technical University of DarmstadtA short isoform of the Tet1 enzyme (Tet1s) that oxidizes the DNA 5-methylcytosine (5mC) mark is overexpressed in tumors. Here the authors show Tet1s, but not full length Tet1, changes localization over the cell cycle upon ubiquitination and Uhrf1 interaction and is targeted to heterochromatin during S-phase. This leads to 5mC oxidation and loss of DNA methylation in heterochromatin.https://doi.org/10.1038/s41467-022-32799-8 |
| spellingShingle | María Arroyo Florian D. Hastert Andreas Zhadan Florian Schelter Susanne Zimbelmann Cathia Rausch Anne K. Ludwig Thomas Carell M. Cristina Cardoso Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation Nature Communications |
| title | Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation |
| title_full | Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation |
| title_fullStr | Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation |
| title_full_unstemmed | Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation |
| title_short | Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation |
| title_sort | isoform specific and ubiquitination dependent recruitment of tet1 to replicating heterochromatin modulates methylcytosine oxidation |
| url | https://doi.org/10.1038/s41467-022-32799-8 |
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