Highly Enantioselective Addition of Phenylethynylzinc to Aldehydes Catalyzed by Chiral Cyclopropane-Based Amino Alcohols

Highly Enantioselective Addition of Phenylethynylzinc to Aldehydes Catalyzed by Chiral Cyclopropane-Based Amino Alcohols

The enantioselective addition of phenylethynylzinc to aldehydes catalyzed by a series of cyclopropane-based amino alcohol ligands 7 was investigated. The reactions afforded chiral propargylic alcohols in high yields (up to 96%) and with excellent enantioselectivities (up to 98% ee) under mild condit...

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Bibliographic Details
Main Authors: Bing Zheng, Zhiyuan Li, Feipeng Liu, Yanhua Wu, Junjian Shen, Qinghua Bian, Shicong Hou, Ming Wang
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Molecules
Subjects:
alkynylation
aldehydes
cyclopropane-based
amino alcohols
asymmetric catalysis
Online Access:http://www.mdpi.com/1420-3049/18/12/15422

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