Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector <it>Anopheles gambiae </it>homozygous for the G119S mutation
<p>Abstract</p> <p>Background</p> <p>The G119S mutation responsible for insensitive acetylcholinesterase resistance to organophosphate and carbamate insecticides has recently been reported from natural populations of <it>Anopheles gambiae </it>in West Africa...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-01-01
|
| Series: | Malaria Journal |
| Online Access: | http://www.malariajournal.com/content/9/1/12 |
| _version_ | 1811264140927303680 |
|---|---|
| author | Noel Valérie Djogbénou Luc Agnew Philip |
| author_facet | Noel Valérie Djogbénou Luc Agnew Philip |
| author_sort | Noel Valérie |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The G119S mutation responsible for insensitive acetylcholinesterase resistance to organophosphate and carbamate insecticides has recently been reported from natural populations of <it>Anopheles gambiae </it>in West Africa. These reports suggest there are costs of resistance associated with this mutation for <it>An. gambiae</it>, especially for homozygous individuals, and these costs could be influential in determining the frequency of carbamate resistance in these populations.</p> <p>Methods</p> <p>Life-history traits of the AcerKis and Kisumu strains of <it>An. gambiae </it>were compared following the manipulation of larval food availability in three separate experiments conducted in an insecticide-free laboratory environment. These two strains share the same genetic background, but differ in being homozygous for the presence or absence of the G119S mutation at the <it>ace-1 </it>locus, respectively.</p> <p>Results</p> <p>Pupae of the resistant strain were significantly more likely to die during pupation than those of the susceptible strain. Ages at pupation were significantly earlier for the resistant strain and their dry starved weights were significantly lighter; this difference in weight remained when the two strains were matched for ages at pupation.</p> <p>Conclusions</p> <p>The main cost of resistance found for <it>An. gambiae </it>mosquitoes homozygous for the G119S mutation was that they were significantly more likely to die during pupation than their susceptible counterparts, and they did so across a range of larval food conditions. Comparing the frequency of G119S in fourth instar larvae and adults emerging from the same populations would provide a way to test whether this cost of resistance is being expressed in natural populations of <it>An. gambiae </it>and influencing the dynamics of this resistance mutation.</p> |
| first_indexed | 2024-04-12T19:58:49Z |
| format | Article |
| id | doaj.art-4bd37d3ec428499b8acf5e5c7676a06a |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-04-12T19:58:49Z |
| publishDate | 2010-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-4bd37d3ec428499b8acf5e5c7676a06a2022-12-22T03:18:36ZengBMCMalaria Journal1475-28752010-01-01911210.1186/1475-2875-9-12Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector <it>Anopheles gambiae </it>homozygous for the G119S mutationNoel ValérieDjogbénou LucAgnew Philip<p>Abstract</p> <p>Background</p> <p>The G119S mutation responsible for insensitive acetylcholinesterase resistance to organophosphate and carbamate insecticides has recently been reported from natural populations of <it>Anopheles gambiae </it>in West Africa. These reports suggest there are costs of resistance associated with this mutation for <it>An. gambiae</it>, especially for homozygous individuals, and these costs could be influential in determining the frequency of carbamate resistance in these populations.</p> <p>Methods</p> <p>Life-history traits of the AcerKis and Kisumu strains of <it>An. gambiae </it>were compared following the manipulation of larval food availability in three separate experiments conducted in an insecticide-free laboratory environment. These two strains share the same genetic background, but differ in being homozygous for the presence or absence of the G119S mutation at the <it>ace-1 </it>locus, respectively.</p> <p>Results</p> <p>Pupae of the resistant strain were significantly more likely to die during pupation than those of the susceptible strain. Ages at pupation were significantly earlier for the resistant strain and their dry starved weights were significantly lighter; this difference in weight remained when the two strains were matched for ages at pupation.</p> <p>Conclusions</p> <p>The main cost of resistance found for <it>An. gambiae </it>mosquitoes homozygous for the G119S mutation was that they were significantly more likely to die during pupation than their susceptible counterparts, and they did so across a range of larval food conditions. Comparing the frequency of G119S in fourth instar larvae and adults emerging from the same populations would provide a way to test whether this cost of resistance is being expressed in natural populations of <it>An. gambiae </it>and influencing the dynamics of this resistance mutation.</p>http://www.malariajournal.com/content/9/1/12 |
| spellingShingle | Noel Valérie Djogbénou Luc Agnew Philip Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector <it>Anopheles gambiae </it>homozygous for the G119S mutation Malaria Journal |
| title | Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector <it>Anopheles gambiae </it>homozygous for the G119S mutation |
| title_full | Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector <it>Anopheles gambiae </it>homozygous for the G119S mutation |
| title_fullStr | Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector <it>Anopheles gambiae </it>homozygous for the G119S mutation |
| title_full_unstemmed | Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector <it>Anopheles gambiae </it>homozygous for the G119S mutation |
| title_short | Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector <it>Anopheles gambiae </it>homozygous for the G119S mutation |
| title_sort | costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector it anopheles gambiae it homozygous for the g119s mutation |
| url | http://www.malariajournal.com/content/9/1/12 |
| work_keys_str_mv | AT noelvalerie costsofinsensitiveacetylcholinesteraseinsecticideresistanceforthemalariavectoritanophelesgambiaeithomozygousfortheg119smutation AT djogbenouluc costsofinsensitiveacetylcholinesteraseinsecticideresistanceforthemalariavectoritanophelesgambiaeithomozygousfortheg119smutation AT agnewphilip costsofinsensitiveacetylcholinesteraseinsecticideresistanceforthemalariavectoritanophelesgambiaeithomozygousfortheg119smutation |