Development and In Vitro Evaluation of Controlled Release Viagra<sup>®</sup> Containing Poloxamer-188 Using Gastroplus<sup>™</sup> PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments

Development and In Vitro Evaluation of Controlled Release Viagra<sup>®</sup> Containing Poloxamer-188 Using Gastroplus<sup>™</sup> PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments

Sildenafil is the active substance in Viagra<sup>®</sup> tablets, which is approved by the FDA to treat sexual dysfunction in men. Poor solubility and short half-life, however, can limit the span of its effectiveness. Therefore, this study focused on an oral controlled release matrix sys...

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Bibliographic Details
Main Authors: Mosab Arafat, Muhammad Sarfraz, Salahdein AbuRuz
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceuticals
Subjects:
sildenafil citrate
poloxamer-188
matrix system
polymer
controlled release
Online Access:https://www.mdpi.com/1424-8247/14/5/479

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