A fresh look at propriospinal interneurons plasticity and intraspinal circuits remodeling after spinal cord injury
Spinal cord injury (SCI) disrupts communication between the brain-derived descending commands and the intraspinal circuits, the central pattern generator (CPG), that execute movements. Dynamic changes in the interaction of the brain-spinal cord as well as in structure-function relationships play a v...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | IBRO Neuroscience Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242123000325 |
| _version_ | 1797804524849594368 |
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| author | Jianwei Cheng Na N. Guan |
| author_facet | Jianwei Cheng Na N. Guan |
| author_sort | Jianwei Cheng |
| collection | DOAJ |
| description | Spinal cord injury (SCI) disrupts communication between the brain-derived descending commands and the intraspinal circuits, the central pattern generator (CPG), that execute movements. Dynamic changes in the interaction of the brain-spinal cord as well as in structure-function relationships play a vital role in the determination of neurological function restoration. These changes also have important clinical implications for the treatment of patients with SCI. After SCI, at both brain and spinal cord levels, detour circuits formation and neuronal plasticity have been linked to functional improvement under the condition of spontaneous recovery as well as electrical stimulation- and rehabilitative training-assisted recovery. The principles governing neural circuit remodeling and the neuronal subtypes specifically involved during the recovery from SCI are largely unknown. In the present review, we focus on how multi-level neural circuits are reconstructed after SCI. We highlight some new studies using rodent and zebrafish SCI models that describe how the intraspinal detour circuits are reconstructed and the important roles of spinal excitatory interneurons. |
| first_indexed | 2024-03-13T05:38:29Z |
| format | Article |
| id | doaj.art-4bd4471001594bcf864bd74e607af51c |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-03-13T05:38:29Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-4bd4471001594bcf864bd74e607af51c2023-06-14T04:34:43ZengElsevierIBRO Neuroscience Reports2667-24212023-06-0114441446A fresh look at propriospinal interneurons plasticity and intraspinal circuits remodeling after spinal cord injuryJianwei Cheng0Na N. Guan1Motor Control Laboratory, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, Tongji University School of Medicine, Shanghai, China; Clinical Center for Brain and Spinal Cord Research, Tongji University, 200092 Shanghai, ChinaMotor Control Laboratory, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, Tongji University School of Medicine, Shanghai, China; Clinical Center for Brain and Spinal Cord Research, Tongji University, 200092 Shanghai, China; Corresponding author at: Motor Control Laboratory, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, Tongji University School of Medicine, Shanghai, China.Spinal cord injury (SCI) disrupts communication between the brain-derived descending commands and the intraspinal circuits, the central pattern generator (CPG), that execute movements. Dynamic changes in the interaction of the brain-spinal cord as well as in structure-function relationships play a vital role in the determination of neurological function restoration. These changes also have important clinical implications for the treatment of patients with SCI. After SCI, at both brain and spinal cord levels, detour circuits formation and neuronal plasticity have been linked to functional improvement under the condition of spontaneous recovery as well as electrical stimulation- and rehabilitative training-assisted recovery. The principles governing neural circuit remodeling and the neuronal subtypes specifically involved during the recovery from SCI are largely unknown. In the present review, we focus on how multi-level neural circuits are reconstructed after SCI. We highlight some new studies using rodent and zebrafish SCI models that describe how the intraspinal detour circuits are reconstructed and the important roles of spinal excitatory interneurons.http://www.sciencedirect.com/science/article/pii/S2667242123000325Spinal CPGSpinal cord injuryIntraspinal interneuronsPropriospinal neuronsDetourCircuit plasticity |
| spellingShingle | Jianwei Cheng Na N. Guan A fresh look at propriospinal interneurons plasticity and intraspinal circuits remodeling after spinal cord injury IBRO Neuroscience Reports Spinal CPG Spinal cord injury Intraspinal interneurons Propriospinal neurons Detour Circuit plasticity |
| title | A fresh look at propriospinal interneurons plasticity and intraspinal circuits remodeling after spinal cord injury |
| title_full | A fresh look at propriospinal interneurons plasticity and intraspinal circuits remodeling after spinal cord injury |
| title_fullStr | A fresh look at propriospinal interneurons plasticity and intraspinal circuits remodeling after spinal cord injury |
| title_full_unstemmed | A fresh look at propriospinal interneurons plasticity and intraspinal circuits remodeling after spinal cord injury |
| title_short | A fresh look at propriospinal interneurons plasticity and intraspinal circuits remodeling after spinal cord injury |
| title_sort | fresh look at propriospinal interneurons plasticity and intraspinal circuits remodeling after spinal cord injury |
| topic | Spinal CPG Spinal cord injury Intraspinal interneurons Propriospinal neurons Detour Circuit plasticity |
| url | http://www.sciencedirect.com/science/article/pii/S2667242123000325 |
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