TGF-β2 antisense oligonucleotide enhances T-cell mediated anti-tumor activities by IL-2 via attenuation of fibrotic reaction in a humanized mouse model of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, with high mortality and recurrence rate. In this study, we generated a human immune system mouse model by transplanting human peripheral blood mononuclear cells into NSG-B2m mice followed by xenografting AsPC-1 cells, aft...
Main Authors: | Hong Kyu Lee, Min-Woo Nam, Ryeo-Eun Go, Jihye Koo, Tae Hun Kim, Jun-Eui Park, Kyung-Chul Choi |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023-03-01
|
Series: | Biomedicine & Pharmacotherapy |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222016018 |
Similar Items
-
Quantitative fluorescence imaging of antisense oligonucleotide mediated knockdown
by: Chan, Nicholas Zhen Woon
Published: (2024) -
In-silico study of antisense oligonucleotide antibiotics
by: Erica S. Chen, et al.
Published: (2023-11-01) -
Antisense oligonucleotides for the arterial hypertension mechanisms study and therapy
by: L. O. Klimov, et al.
Published: (2018-04-01) -
Aptamers and Antisense Oligonucleotides for Diagnosis and Treatment of Hematological Diseases
by: Valentina Giudice, et al.
Published: (2020-05-01) -
Transport Oligonucleotides—A Novel System for Intracellular Delivery of Antisense Therapeutics
by: Oleg V. Markov, et al.
Published: (2020-08-01)