Association of Insulin-like Growth Factor-1 with Bone Mineral Density in Survivors of Childhood Acute Leukemia
In this study, we investigated bone mineral deficits in children who survived childhood acute leukemia and explored the association between the insulin-like growth factor-1 (IGF-1) level and bone mineral density (BMD). This retrospective analysis enrolled 214 patients treated for acute leukemia, mea...
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| Format: | Article |
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MDPI AG
2024-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/7/1296 |
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| author | Seulki Kim Jae Won Yoo Jae Wook Lee Min Ho Jung Bin Cho Byng-Kyu Suh Moon Bae Ahn Nack-Gyun Chung |
| author_facet | Seulki Kim Jae Won Yoo Jae Wook Lee Min Ho Jung Bin Cho Byng-Kyu Suh Moon Bae Ahn Nack-Gyun Chung |
| author_sort | Seulki Kim |
| collection | DOAJ |
| description | In this study, we investigated bone mineral deficits in children who survived childhood acute leukemia and explored the association between the insulin-like growth factor-1 (IGF-1) level and bone mineral density (BMD). This retrospective analysis enrolled 214 patients treated for acute leukemia, measuring various factors including height, weight, body mass index (BMI), and lumbar spine BMD after the end of treatment. The study found an overall prevalence of low BMD in 15% of participants. Notably, IGF-1 levels were significantly different between patients with low BMD and those with normal BMD, and correlation analyses revealed associations of the IGF-1 level and BMI with lumbar spine BMD. Regression analyses further supported this relationship, suggesting that higher IGF-1 levels were associated with a decreased risk of low BMD. The study findings suggest that IGF-1 may serve as a valuable tool for evaluating and predicting osteoporosis in survivors of childhood acute leukemia. |
| first_indexed | 2024-04-24T10:48:43Z |
| format | Article |
| id | doaj.art-4bd7daedce484b178aaeb545acc15cac |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-04-24T10:48:43Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4bd7daedce484b178aaeb545acc15cac2024-04-12T13:15:57ZengMDPI AGCancers2072-66942024-03-01167129610.3390/cancers16071296Association of Insulin-like Growth Factor-1 with Bone Mineral Density in Survivors of Childhood Acute LeukemiaSeulki Kim0Jae Won Yoo1Jae Wook Lee2Min Ho Jung3Bin Cho4Byng-Kyu Suh5Moon Bae Ahn6Nack-Gyun Chung7Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaIn this study, we investigated bone mineral deficits in children who survived childhood acute leukemia and explored the association between the insulin-like growth factor-1 (IGF-1) level and bone mineral density (BMD). This retrospective analysis enrolled 214 patients treated for acute leukemia, measuring various factors including height, weight, body mass index (BMI), and lumbar spine BMD after the end of treatment. The study found an overall prevalence of low BMD in 15% of participants. Notably, IGF-1 levels were significantly different between patients with low BMD and those with normal BMD, and correlation analyses revealed associations of the IGF-1 level and BMI with lumbar spine BMD. Regression analyses further supported this relationship, suggesting that higher IGF-1 levels were associated with a decreased risk of low BMD. The study findings suggest that IGF-1 may serve as a valuable tool for evaluating and predicting osteoporosis in survivors of childhood acute leukemia.https://www.mdpi.com/2072-6694/16/7/1296acute leukemiabone mineral densityinsulin-like growth factor-1vertebral fracture |
| spellingShingle | Seulki Kim Jae Won Yoo Jae Wook Lee Min Ho Jung Bin Cho Byng-Kyu Suh Moon Bae Ahn Nack-Gyun Chung Association of Insulin-like Growth Factor-1 with Bone Mineral Density in Survivors of Childhood Acute Leukemia Cancers acute leukemia bone mineral density insulin-like growth factor-1 vertebral fracture |
| title | Association of Insulin-like Growth Factor-1 with Bone Mineral Density in Survivors of Childhood Acute Leukemia |
| title_full | Association of Insulin-like Growth Factor-1 with Bone Mineral Density in Survivors of Childhood Acute Leukemia |
| title_fullStr | Association of Insulin-like Growth Factor-1 with Bone Mineral Density in Survivors of Childhood Acute Leukemia |
| title_full_unstemmed | Association of Insulin-like Growth Factor-1 with Bone Mineral Density in Survivors of Childhood Acute Leukemia |
| title_short | Association of Insulin-like Growth Factor-1 with Bone Mineral Density in Survivors of Childhood Acute Leukemia |
| title_sort | association of insulin like growth factor 1 with bone mineral density in survivors of childhood acute leukemia |
| topic | acute leukemia bone mineral density insulin-like growth factor-1 vertebral fracture |
| url | https://www.mdpi.com/2072-6694/16/7/1296 |
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