Phylogenetic and chronological analysis of proteins causing Alzheimer's, Parkinson's and Huntington's diseases
It is evident that Neurodegenerative diseases (Alzheimer's, Parkinson's and Huntington's) have many similarities at cellular and molecular level as they carry parallel mechanisms including protein aggregation and inclusion body formation caused by protein mis-folding. The main objecti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Bulgarian Academy of Sciences
2012-09-01
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| Series: | International Journal Bioautomation |
| Subjects: | |
| Online Access: | http://www.clbme.bas.bg/bioautomation/2012/vol_16.3/files/16.3_02.pdf |
| _version_ | 1819111220763951104 |
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| author | Bilal Hussain Hina Khalid Shahid Nadeem Tayyaba Sultana Saima Aslam |
| author_facet | Bilal Hussain Hina Khalid Shahid Nadeem Tayyaba Sultana Saima Aslam |
| author_sort | Bilal Hussain |
| collection | DOAJ |
| description | It is evident that Neurodegenerative diseases (Alzheimer's, Parkinson's and Huntington's) have many similarities at cellular and molecular level as they carry parallel mechanisms including protein aggregation and inclusion body formation caused by protein mis-folding. The main objective of this study was to have detailed insight on variation and resemblance among these proteins. One hundred and four protein sequences, both directly and indirectly involved in disease mechanism to perform phylogenetic analysis revealing insight on evolutionary relationship among these proteins, were selected. The percentage of replicate trees, in which the associated taxa clustered together in the bootstrap test, was 1000 replicates. Various statistical tests were performed for the confirmation of results e.g., Tajma's Neutrality Test showed D gt 6, nucleotide diversity π gt 0.6 and ps value as greater than 1. Phylogenetic analysis showed that the protein sequences of neurodegenerative diseases had high sequence similarity and identity to each other as depicted by the evolutionary tree. It showed the similar mechanism of evolving from each other and had similar mechanism of generating mis-folding leading towards symptoms of disease. |
| first_indexed | 2024-12-22T03:54:09Z |
| format | Article |
| id | doaj.art-4bdb3a8eff764fb7aa4ea892615ac813 |
| institution | Directory Open Access Journal |
| issn | 1314-1902 1314-2321 |
| language | English |
| last_indexed | 2024-12-22T03:54:09Z |
| publishDate | 2012-09-01 |
| publisher | Bulgarian Academy of Sciences |
| record_format | Article |
| series | International Journal Bioautomation |
| spelling | doaj.art-4bdb3a8eff764fb7aa4ea892615ac8132022-12-21T18:39:56ZengBulgarian Academy of SciencesInternational Journal Bioautomation1314-19021314-23212012-09-01163165178Phylogenetic and chronological analysis of proteins causing Alzheimer's, Parkinson's and Huntington's diseasesBilal HussainHina KhalidShahid NadeemTayyaba SultanaSaima AslamIt is evident that Neurodegenerative diseases (Alzheimer's, Parkinson's and Huntington's) have many similarities at cellular and molecular level as they carry parallel mechanisms including protein aggregation and inclusion body formation caused by protein mis-folding. The main objective of this study was to have detailed insight on variation and resemblance among these proteins. One hundred and four protein sequences, both directly and indirectly involved in disease mechanism to perform phylogenetic analysis revealing insight on evolutionary relationship among these proteins, were selected. The percentage of replicate trees, in which the associated taxa clustered together in the bootstrap test, was 1000 replicates. Various statistical tests were performed for the confirmation of results e.g., Tajma's Neutrality Test showed D gt 6, nucleotide diversity π gt 0.6 and ps value as greater than 1. Phylogenetic analysis showed that the protein sequences of neurodegenerative diseases had high sequence similarity and identity to each other as depicted by the evolutionary tree. It showed the similar mechanism of evolving from each other and had similar mechanism of generating mis-folding leading towards symptoms of disease.http://www.clbme.bas.bg/bioautomation/2012/vol_16.3/files/16.3_02.pdfPhylogeneticsAlzheimer'sParkinson'sHuntington's diseases |
| spellingShingle | Bilal Hussain Hina Khalid Shahid Nadeem Tayyaba Sultana Saima Aslam Phylogenetic and chronological analysis of proteins causing Alzheimer's, Parkinson's and Huntington's diseases International Journal Bioautomation Phylogenetics Alzheimer's Parkinson's Huntington's diseases |
| title | Phylogenetic and chronological analysis of proteins causing Alzheimer's, Parkinson's and Huntington's diseases |
| title_full | Phylogenetic and chronological analysis of proteins causing Alzheimer's, Parkinson's and Huntington's diseases |
| title_fullStr | Phylogenetic and chronological analysis of proteins causing Alzheimer's, Parkinson's and Huntington's diseases |
| title_full_unstemmed | Phylogenetic and chronological analysis of proteins causing Alzheimer's, Parkinson's and Huntington's diseases |
| title_short | Phylogenetic and chronological analysis of proteins causing Alzheimer's, Parkinson's and Huntington's diseases |
| title_sort | phylogenetic and chronological analysis of proteins causing alzheimer s parkinson s and huntington s diseases |
| topic | Phylogenetics Alzheimer's Parkinson's Huntington's diseases |
| url | http://www.clbme.bas.bg/bioautomation/2012/vol_16.3/files/16.3_02.pdf |
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